The Economic Impact of Methicillin-Resistant Staphylococcus aureus in Canadian Hospitals

Kim, Tony; Oh, Paul; Simor, Andrew E.

doi:10.1086/501871

Cited by 171 publications

(113 citation statements)

References 38 publications

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“…The total cost of medications associated with our treatment protocol was estimated to be $32.00 per treatment course. This is similar to other estimates of cost across Canada and the United States (24,25). Canadian data have estimated a cost of $14,360 per patient when MRSA colonization progresses to infection (25).…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Decolonization of Methicillin‐Resistant Staphylococcus aureus during Routine Hospital Care: Efficacy and Long‐Term Follow‐Up

Dow

Field

Mancuso

et al. 2010

Canadian Journal of Infectious Diseases and Medical Microbiolog

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BACkGrounD/oBJECtIvE: Methicillin-resistant Staphylococcus aureus (MRSA) colonization is associated with a significant risk of subsequent MRSA infection in the hospital setting. The use of decolonization as an infection control strategy remains highly controversial despite publications evaluating more than 40 different decolonization regimens over the past 60 years. The present study describes the benefits and potential drawbacks of such an approach in the patient population. MEthoDs: A retrospective cohort study was performed to assess the efficacy and subsequent outcome for patients with newly identified MRSA colonization at the Horizon Health Network in Moncton, New Brunswick. rEsults: A total of 241 patients with MRSA colonization or infection during the study period (2000 to 2005 inclusive) were identified. Eighty-nine MRSA-positive patients were decolonized according to a standardized regimen (hospital protocol group), and 98 received an alternative decolonization regimen (other treatment group). No attempt at decolonization was made for 54 patients (no treatment group). The hospital protocol group demonstrated superior overall successful decolonization compared with the other treatment group (67 of 84 [80%] versus 48 of 89 [54%]; OR 3.3; 95% CI 1.6 to 7.1; P=0.0004) and the no treatment group (four of 43 [9%]; OR 36.9; 95% CI 11.2 to 161.7; P<0.000001). The mean observed duration of culture negativity for the subgroup who remained MRSA culture negative over the long term was 419±398 days (range one to 1817 days). Successful decolonization occurred in 115 patients and permitted subsequent release from contact isolation for 4530 patient-days. The rate of clinical infection with MRSA was significantly lower in the hospital protocol group versus the other treatment group (16 of 89 [18%] versus 37 of 98 [38%]; OR 0.38; 95% CI 0.18 to 0.78; P=0.003). ConClusIon:The present study supports recent reports indicating that MRSA decolonization can be successful using a multifactorial approach (chlorhexidine soap, enhanced hygiene/housekeeping and combination oral/topical antimicrobial therapy) in hospitalized patients, both over the short and long term. Unlike previous studies, decolonization appeared to be effective in a relatively unselected population, including patients with lines and catheters. Inability to decolonize was most closely associated with failure to use a standardized decolonization protocol.

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Section: Discussionsupporting

confidence: 87%

“…This is similar to other estimates of cost across Canada and the United States (24,25). Canadian data have estimated a cost of $14,360 per patient when MRSA colonization progresses to infection (25). This total has been derived from increased hospital stay, isolation costs and management.…”

Section: Discussionsupporting

confidence: 81%

Decolonization of Methicillin‐Resistant Staphylococcus aureus during Routine Hospital Care: Efficacy and Long‐Term Follow‐Up

Dow

Field

Mancuso

et al. 2010

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…1,2 The MRSA is characterized by its resistance to β-lactam antibiotics and acquiring resistance to several groups of other drugs that result in longer hospital stays and increased cost of treatment. 3 The CA-MRSA affect healthy children without the risk factors usually linked with HA-MRSA infections. 4 Compared with HA-MRSA, CA-MRSA are often less resistant to several groups of non-lactam antimicrobial agents and frequently carry the genes lukS-PV and lukF-PV coding for the cytotoxin Panton-Valentine leucocidin (PVL).…”

Section: Introductionmentioning

confidence: 99%

Nasal Carriage of Multi-Drug Resistant Panton-Valentine Leucocidin-Positive Methicillin-Resistant Staphylococcus aureus in Children in Tripoli-Libya

Al-haddad

Zorgani

Ghenghesh

2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Methicillin-resistant Staphylococcus aureus (MRSA) colonized children are at an increased risk of developing infections than methicillin-sensitive S. aureus colonized children. Nasal specimens from inpatient children, mothers of inpatient children, healthcare workers, and outpatient children at Tripoli Children Hospital (TCH) were examined for MRSA by chromogenic MRSA ID medium. Susceptibility of MRSA isolates to antibiotics was determined by the disc diffusion method. The nasal carriage rate of MRSA among inpatient children (8.3%, 24 of 289), their mothers (11%, 22 of 200), and healthcare workers (12.4%, 22 of 178) was significantly higher than among outpatient children (2.2%, 2 of 91) (P 0.05, P 0.02, and P 0.006, respectively). Of the examined MRSA isolates (N = 35) 10 (28.6%) were positive for Panton-Valentine leucocidin genes by polymerase chain reaction. Multidrug resistance was found in 24.3% (17 of 70) of MRSA isolates. Nasal carriage of multidrug-resistant Panton-Valentine leucocidin-positive MRSA is not uncommon among inpatient children and their mothers in Tripoli.

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“…The consequences faced by the health are longer hospital stays and greater costs of approximately doubles the expenditure per patient ultimately a huge burden on patients with low status [5] . [6] .…”

Section: Introductionmentioning

confidence: 99%

Detection of mrsa using three different methods such as oxacillin agar screening method, cefoxitin disc diffusion method and meca gene by pcr among clinical isolates of staphylococcus aureus from tertiary care hospital in kancheepuram dist

F¹,

Gopinath²

2017

Int j curr adv res

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The Economic Impact of Methicillin-Resistant Staphylococcus aureus in Canadian Hospitals

Abstract: These results indicate that there is a substantial economic burden associated with MRSA in Canadian hospitals. These costs will continue to rise if the incidence of MRSA increases further.

Cited by 171 publications

References 38 publications

Decolonization of Methicillin‐Resistant Staphylococcus aureus during Routine Hospital Care: Efficacy and Long‐Term Follow‐Up

Decolonization of Methicillin‐Resistant Staphylococcus aureus during Routine Hospital Care: Efficacy and Long‐Term Follow‐Up

Nasal Carriage of Multi-Drug Resistant Panton-Valentine Leucocidin-Positive Methicillin-Resistant Staphylococcus aureus in Children in Tripoli-Libya

Detection of mrsa using three different methods such as oxacillin agar screening method, cefoxitin disc diffusion method and meca gene by pcr among clinical isolates of staphylococcus aureus from tertiary care hospital in kancheepuram dist

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