Conversion of pastures to cropland is one of the most important issues facing livestock farming in Burkina Faso. This study examined the impact of land use/cover change on pastoral livestock farming in Boulgou province between 1980 and 2013. Landsat satellite images (1989, 2001 and 2013) and socio-economic data were analysed. The interpretation of the classified Landsat images revealed an increase in cropland from 20.5% in 1989 to 36.7% in 2013. This resulted mainly from the conversion of woody savannah and shrub and grass savannah to cropland. Pastoral livestock farmers reported that the major drivers of vegetation loss were drought (95.1 %), population growth (91.8%), cropland increase (91.4%), extraction of fuel wood (69.8%) and increase in livestock population (65.4). These changes affect livestock farming through reduction of pasture, poor access to water and reduction of livestock mobility routes according to the farmers. This calls for regional and national policies to protect grazing areas in Burkina Faso that are similar to policies being implemented for forest and other types of vegetation cover in other countries. For such pastoral policies to be successful, issues concerning the mobility of livestock farmers must be enshrined into such policies and this study is an example of information source for these policies.