The economics of parasitic diseases: Research priorities

Rosenfield, Patricia L.; Golladay, Fredrick L.; Davidson, Rose K.

doi:10.1016/0277-9536(84)90317-4

Cited by 24 publications

(9 citation statements)

References 2 publications

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“…The reason could probably be due to dissimilar socio-economic status and environmental conditions associated with the two diverse populations. Also, these people are from poor families lacking proper housing, safe water supplies and hygienic waste disposal systems[20]. In Malaysia, about 15% of food-borne disease outbreak are the result of contamination by food-handlers[21].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of intestinal parasitic infections in certified food-handlers working in food establishments in the City of Nairobi, Kenya

Kamau

Aloo-Obudho

Kabiru

et al. 2012

Journal of Biomedical Research

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Most intestinal parasites are cosmopolitan with the highest prevalence in the tropics and subtopics. Rural-to-urban migration rapidly increases the number of food eating places in towns and their environs. Some of these eating estabishments have poor sanitation and are overcrowded, facilitating disease transmission, especially through food-handling. Our investigations in Nairobi, therefore, were set to determine the presence of intestinal parasites in food-handlers with valid medical certificates. Direct and concentrated stool processing techniques were used. Chisquare test and ANOVA were used for data analysis. The parasites Ascaris lumbricoides, Entamoeba histolytica and Giardia lamblia were observed in certified food-handlers. Significant difference was found in parasite frequency by eating classes and gender (χ2 = 9.49, P = 0.73), (F = 1.495, P = 0.297), but not in parasite occurrence between age brackets (χ2 = 6.99, P = 0.039). The six-month medical certificate validity period may contribute significantly to the presence of intestinal parasites in certified food-handlers.

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Section: Discussionmentioning

confidence: 99%

Prevalence of intestinal parasitic infections in certified food-handlers working in food establishments in the City of Nairobi, Kenya

Kamau

Aloo-Obudho

Kabiru

et al. 2012

Journal of Biomedical Research

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“…Due to the subtropical monsoonal climate and being a least developed country, B angladesh is endemic for helminthes infection especially for ST H. Poor housing conditions, over crowding, scarcity of safe drinking water and lack of proper hygiene and sanitation are common factors that contribute to the increased prevalence of these parasites in this country 15,16,[17][18][19][20][21][22][23] . People of all age have been observed to experience such infection with the principal helminthes species being A .…”

Section: St H Infections Commonly Occur Both In Rural and The Slums Omentioning

confidence: 99%

Prevalence of Soil Transmitted Helminthes (STH) Infection among Children Aged 2-17 Years in Urban and Rural Areas of Dhaka District in Bangladesh

Banu

Ahmed

Jubayer

et al. 2013

Bangladesh J Med Microbiol

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A multi-staged cr oss sectional study was conducted among childr en aged 2 -17 year s to assess the level of soil tr ansmitted helminthes (ST H ) infections and its r elation to socio-demogr aphic char acter istics among them. T wo thousand childr en wer e r andomly selected fr om two r ur al and four differ ent communities of ur ban ar eas of Dhaka distr ict since November 2009 to J une 2010. F our differ ent communities classified as higher , medium, poor er and slum/ low socio-economic gr oups fr om ur ban ar eas wer e selected on the basis of their place of r esidence with differ ent socio-economic status. Ur ban study subjects wer e again sub gr ouped into upper (higher and medium socio-economic) and lower (poor er and slum/low socio-economic) classes. Stool specimens of the r espondents wer e collected and tested at the Par asitology depar tment of I E DC R , using the K ato-katz faecal technique for identification of helminthes eggs following their mor phology (A . lumbr icoides, T tr ichiur a, and A . duodenale), and lar val stage (S. ster cor alis). A bout 32.15% study population har bor ed at least one of the four helminthes species. B aseline pr evalence of infections and mean par asite loads for A scar is lumbr icoides wer e 40.61% and 600.80 e/g, for T r ichur is tr ichiur a 30.42% and 206.11e/g, and for A . duodenale 6.80% and 78.75 e/g. T hr ee childr en (0.49% ) wer e positive for Str ongyloides ster cor alis. Single infection of 78.32 % and double infection of 21.68 % wer e r ecor ded. Single infection of A . lumbr icoides (40.61% ) and T tr ichiur a (30.42% ) and double infection of A . lumbr icoides -T tr ichiur a (18.61 % ) wer e mor e pr evalent. T he pr evalence of ST H infection was 25.47 % and 38.68 % for r ur al and ur ban ar eas r espectively (P <.001). A mong ur ban study subjects, the distr ibution of ST H infection was 0.0 % in the higher (living in higher socioeconomic ar eas) (only 3 samples could be collected), 26.75 % in medium (living in medium socio-economic ar eas), 45.95 % in poor er and 50.54 % in slum/low socio-economic gr oups. Significantly higher number of ST H infection was obser ved among lower than that in upper socio-economic classes (P <.001). T hese r esults suggest that ST H infections r emain a ser ious health pr oblem among childr en in B angladesh and need appr opr iate pr evention and contr ol measur es.K ey wor ds: Pr evalence, ST H , childr en, par asite load, ur ban and r ur al ar eas, K ato-katz technique.

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“…Lymphatic Filariais is an infectious disease that causes serious social and economic burden [2]. Lymphatic filariasis (LF) is a mosquito-borne tropical disease caused by the nematode parasites Wuchereria bancrofti, Brugia malayi and Brugia.timori live in human lymph system [3].…”

Section: Introductionmentioning

confidence: 99%

Predicted binding of certain antifilarial compounds with glutathione-S-transferase of human Filariids

Baig¹,

Bajpai²,

Srivastava³

et al. 2013

Bioinformation

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Glutathione-S-transferase is a major phase-II detoxification enzyme in parasitic helminthes. Previous research highlights the importance of GSTs in the establishment of chronic infections in cytotoxic microenvironments. Filarial nematodes depend on these detoxification enzymes for their survival in the host. GST plays an important role in filariasis and other diseases. GST from W.bancrofti and B.malayi are very much different from human GST. This structural difference makes GST potential chemotherapeutic targets for antifilarial treatment. In this study we have checked the efficacy of some well known antifilarial compounds against GST from B.malayi and W.bancrofti. The structure of BmGST was modeled using modeller9v10 and was submitted to PMDB. Molecular docking study reveals arbindazole to be the most potent compounds against GST from both the filarial parasites. Role of some residues playing important role in the binding of compounds within the active site of GST has also been revealed in the present study. The BmGST and WbGST structural information and docking studies could aid in screening new antifilarials or selective inhibitors for chemotherapy against filariasis.AbbreviationsGST - Glutathione-S-transferase, Bm - Brugia malayi, Wb - Wuchereria bancrofti.

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The economics of parasitic diseases: Research priorities

Cited by 24 publications

References 2 publications

Prevalence of intestinal parasitic infections in certified food-handlers working in food establishments in the City of Nairobi, Kenya

Prevalence of intestinal parasitic infections in certified food-handlers working in food establishments in the City of Nairobi, Kenya

Prevalence of Soil Transmitted Helminthes (STH) Infection among Children Aged 2-17 Years in Urban and Rural Areas of Dhaka District in Bangladesh

Predicted binding of certain antifilarial compounds with glutathione-S-transferase of human Filariids

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