The edible tomato COVID-19 vaccine, TOMAVAC, induces neutralising IgGs

Abdurakhmonov, Ibrokhim Y.; Buriev, Zabardast T.; Shermatov, Shukhrat E.; Usmanov, Dilshod Erkinbaevich; Mirzakhmedov, Mukhammadjon; Ubaydullaeva, Khurshida A.; Kamburova, Venera; Rakhmanov, Bakhtiyor; Ayubov, Mirzakamol S.; Abdullaev, Adkham N.; Eshmurzaev, Jakhongir; Mamajonov, Behzod; Tulanov, Akmal; Ismailova, Adolat; Petrova, T. M.; Rozumbetov, Ramazan; Aripova, Tamara; Muminov, Muzaffar; Ermatova, Khusnora; Dalimova, Dilbar; Turdikulova, Shahlo; Abdukarimov, A

doi:10.21203/rs.3.rs-2447951/v1

Cited by 3 publications

(2 citation statements)

References 19 publications

(42 reference statements)

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“…They were the second wave of the coronavirus disease pandemic, which had spread throughout the country by that period. DNA-based and plantbased edible vaccines have been developed using these sequences of the SARS-CoV-2 spread in Uzbekistan, which are currently in the clinical trial stages [16].…”

Section: Discussionmentioning

confidence: 99%

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Identification of Delta Variant-Specific Mutations of SARS-CoV-2 Genomes Found in Uzbek Patients by Amplicon Sequencing

Ayubov¹,

Buriev²,

Mirzakhmedov³

et al. 2023

Preprint

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The rapid changes in the coronavirus genomes are creating new strains over time after the first variation found in Wuhan in 2019. SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) genotypes need periodically undergo whole genome sequencing. Genome sequencing has been extremely helpful in combating this virus because so many diagnoses, treatments, and vaccinations have been developed against it. To achieve this, we generated 17 high-quality whole-genome sequence data from 48 SARS-CoV-2 genotypes of COVID-19 patients who tested positive by PCR in the Tashkent city of Uzbekistan. We identified nucleotide polymorphisms, including nonsynonymous (missense) and synonymous mutations in the coding regions of the sequenced sample genomes. All whole genome sequences were categorized by phylogenetic analysis into the G clade (or GK sub-clade). A total of 134 mutations were identified, consisting of 65 shared and 69 unique mutations. Collectively, nucleotide changes represented one frameshift mutation, one conservative and disruptive insertion deletion, four upstream region mutations, four downstream region mutations, 39 synonymous mutations, and 84 missense mutations. Furthermore, bioinformatics web tools were used to analyze amino acid changes in virus genomes. Several amino acid mutations were found, which were not found in previously published Delta strain sequences.

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Section: Discussionmentioning

confidence: 99%

“…In the global phylogenetic tree, comparative analysis utilizing SARS-CoV-2 genomes that are known as the Uzbekistan sample genomes into the GK subclade. The sequenced genomic data of coronavirus genotypes were used to develop the edible vaccine in Uzbekistan against coronavirus threats [16].…”

Section: Introductionmentioning

confidence: 99%

Identification of Delta Variant-Specific Mutations of SARS-CoV-2 Genomes Found in Uzbek Patients by Amplicon Sequencing

Ayubov¹,

Buriev²,

Mirzakhmedov³

et al. 2023

Preprint

View full text Add to dashboard Cite

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Development of SARS-CoV-2 neutralizing antibody detection assay by using recombinant plant-produced proteins

Jirarojwattana

Shanmugaraj²,

Rattanapisit³

et al. 2023

Biotechnology Reports

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Modern Plant Biotechnology: An Antidote against Global Food Insecurity

Animasaun,

Adedibu,

Shkryl

et al. 2023

Agronomy

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Food insecurity has become a pressing issue on a worldwide scale as the globe plows through a food crisis. The disastrous impact of this menace has been exacerbated by climate change, frequent conflicts, pandemic outbreaks, and the global economic recession, which have been prevalent in recent years. Although food insecurity prevails globally, it is especially critical in some regions in Africa, East and Southeast Asia, and South America. Several efforts have been made to curb food insecurity; however, none have been able to curtail it sufficiently. Genetic engineering of crops is a fast-growing technology that could be a viable tool for mitigating food insecurity. Crop varieties resistant to pests and diseases, abiotic stress, spoilage, or specific herbicides have been developed using this technology. Crops have been modified for increased yield, nutritional content, essential vitamins, and micro-mineral fortification. More intriguing is the advent of plant-derived edible vaccines, which prove equally effective and significantly affordable. However, in many countries, government policies pose a limiting factor for the acceptance of this technology. This article discusses the genetic modification of crops, highlighting its origins, methods, applications, achievements, impact, acceptance, distribution, and potential as a viable antidote to global food insecurity.

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The edible tomato COVID-19 vaccine, TOMAVAC, induces neutralising IgGs

Cited by 3 publications

References 19 publications

Identification of Delta Variant-Specific Mutations of SARS-CoV-2 Genomes Found in Uzbek Patients by Amplicon Sequencing

Identification of Delta Variant-Specific Mutations of SARS-CoV-2 Genomes Found in Uzbek Patients by Amplicon Sequencing

Development of SARS-CoV-2 neutralizing antibody detection assay by using recombinant plant-produced proteins

Modern Plant Biotechnology: An Antidote against Global Food Insecurity

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