The eEF1A protein in cancer: Clinical significance, oncogenic mechanisms, and targeted therapeutic strategies

Zhang, Weicheng; Wang, Jiyan; Shan, Changliang

doi:10.1016/j.phrs.2024.107195

Pharmacological Research

2024

DOI: 10.1016/j.phrs.2024.107195

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The eEF1A protein in cancer: Clinical significance, oncogenic mechanisms, and targeted therapeutic strategies

Weicheng Zhang,

Jiyan Wang,

Changliang Shan

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2024

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Cited by 2 publications

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Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Liu,

Li,

2024

Pharmacological Research

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Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Liu,

Li,

2024

Pharmacological Research

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Exploiting Translation Machinery for Cancer Therapy: Translation Factors as Promising Targets

Sehrawat

2024

IJMS

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Eukaryotic protein translation has slowly gained the scientific community’s attention for its advanced and powerful therapeutic potential. However, recent technical developments in studying ribosomes and global translation have revolutionized our understanding of this complex multistep process. These developments have improved and deepened the current knowledge of mRNA translation, sparking excitement and new possibilities in this field. Translation factors are crucial for maintaining protein synthesis homeostasis. Since actively proliferating cancer cells depend on protein synthesis, dysregulated protein translation is central to tumorigenesis. Translation factors and their abnormal expressions directly affect multiple oncogenes and tumor suppressors. Recently, small molecules have been used to target translation factors, resulting in translation inhibition in a gene-specific manner, opening the door for developing translation inhibitors that can lead to novel chemotherapeutic drugs for treating multiple cancer types caused by dysregulated translation machinery. This review comprehensively summarizes the involvement of translation factors in tumor progression and oncogenesis. Also, it sheds light on the evolution of translation factors as novel drug targets for developing future therapeutic drugs for treating cancer.

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The eEF1A protein in cancer: Clinical significance, oncogenic mechanisms, and targeted therapeutic strategies

Cited by 2 publications

References 299 publications

Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Exploiting Translation Machinery for Cancer Therapy: Translation Factors as Promising Targets

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