The EEG in intrinsic supratentorial brain tumors: A comparative evaluation

Decker, Douglass A; Knott, John R.

doi:10.1016/0013-4694(72)90157-5

Cited by 30 publications

(22 citation statements)

References 9 publications

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“…MEG was also found to be more sensitive than conventional MRI or EEG in detecting abnormalities in mTBI patients (Lewine et al, 1999(Lewine et al, , 2007. Unlike normal resting-state MEG data, which is dominated by neuronal activity with frequencies above 8 Hz, injured neuronal tissues (due to head trauma, brain tumors, stroke, and epilepsy) generate abnormal focal or multi-focal lowfrequency neuronal magnetic signals (delta-band 1-4 Hz, or theta-band 5-7 Hz) that can be directly measured and localized using MEG de Jongh et al, 2003;Decker and Knott, 1972;Lewine et al, 1999;Lewine and Orrison, 1995;Nagata et al, 1985;Vieth et al, 1996). While TBI is not the only neurological disorder that generates abnormal slow-wave, in practice, brain tumors, stroke, and epilepsy can be easily ruled out based on structural imaging (i.e., CT and MRI for tumor and stroke) and medical history (for epilepsy).…”

Section: Clinicalmentioning

confidence: 99%

The role of biomarkers and MEG-based imaging markers in the diagnosis of post-traumatic stress disorder and blast-induced mild traumatic brain injury

Huang

Risling

Baker

2016

Psychoneuroendocrinology

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SummaryBackground: Pervasive use of improvised explosive devices (IEDs), rocket-propelled grenades, and land mines in the recent conflicts in Iraq and Afghanistan has brought traumatic brain injury (TBI) and its impact on health outcomes into public awareness. Blast injuries have been deemed signature wounds of these wars. War-related TBI is not new, having become prevalent during WWI and remaining medically relevant in WWII and beyond. Medicine's past attempts to accurately diagnose and disentangle the pathophysiology of war-related TBI parallels current lines of inquiry and highlights limitations in methodology and attribution of symptom etiology, be it organic, psychological, or behavioral. New approaches and biomarkers are needed. Preclinical: Serological biomarkers and biomarkers of injury obtained with imaging techniques represent cornerstones in the translation between experimental data and clinical observations. Experimental models for blast related TBI and PTSD can generate critical data on injury threshold, for example for white matter injury from acceleration. Carefully verified and validated models can be evaluated with gene expression arrays and proteomics to identify new candidates for serological biomarkers. Such models can also be analyzed with diffusion MRI and microscopy in order to identify criteria for detection of diffuse white matter injuries, such as DAI (diffuse axonal injury). The experimental models can also be analyzed with focus on injury outcome in brain stem regions, such as locus coeruleus or nucleus raphe magnus that can be involved in response to anxiety changes. * Corresponding author at: UCSD Radiology Imaging Laboratory, San Diego, CA 92121, USA. Tel.: +1 858 534 1254; fax: +1 8585346046. E-mail address: mxhuang@ucsd.edu (M. Huang). Clinical: Mild (and some moderate) TBI can be difficult to diagnose because the injuries are often not detectable on conventional MRI or CT. There is accumulating evidence that injured brain tissues in TBI patients generate abnormal low-frequency magnetic activity (ALFMA, peaked at 1-4 Hz) that can be measured and localized by magnetoencephalography (MEG). MEG imaging detects TBI abnormalities at the rates of 87% for the mild TBI, group (blast-induced plus non-blast causes) and 100% for the moderate group. Among the mild TBI patients, the rates of abnormalities are 96% and 77% for the blast and non-blast TBI groups, respectively. There is emerging evidence based on fMRI and MEG studies showing hyper-activity in the amygdala and hypo-activity in prefrontal cortex in individuals with PTSD. MEG signal may serve as a sensitive imaging marker for mTBI, distinguishable from abnormalities generated in association with PTSD. More work is needed to fully describe physiological mechanisms of post-concussive symptoms.Published by Elsevier Ltd. BackgroundBlast injuries are deemed the signature wounds of the first wars (Afghanistan and Iraq) of the 21st century (Lancet, 2007;Galarneau et al., 2008). According to a recent U.S. Department Veterans Affairs (DVA) ...

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Section: Clinicalmentioning

confidence: 99%

The role of biomarkers and MEG-based imaging markers in the diagnosis of post-traumatic stress disorder and blast-induced mild traumatic brain injury

Huang

Risling

Baker

2016

Psychoneuroendocrinology

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“…These figures compare well with those of Murphy et al (1967) and of Hasegawa and Aird (1963). However, they are higher than those of some other authors (Afifi et al 1965, Wang et al 1965, Decker and Knott 1972. The accuracy in localisation of SOLs in the frontal, temporal, and temporo-parietooccipital junctional areas was particularly good in comparison to clinical loealisation (Table 1).…”

Section: Discussionmentioning

confidence: 48%

“…Even though in most of the published series lateralisation in cerebral hemisphere SOLs has been noted to be quite frequent (90-95%), the loealisation percentage has varied from 50 to 90 (Kiloh and Osselton 1961, Afifi et al 1965, Wang et al 1965, Murphy et al 1967, Cabrini et M. 1968, Kolakowska et al 1971, Decker and Knott 1972. In the present series of cerebral hemisphere SOLs EEG gave good localisation in 82.2% and lateralisation in a further 13.9%.…”

Section: Discussionmentioning

confidence: 48%

“…Tumours in these sites producing clinical evidence of their presence are accompanied by abnormal EEGs in 75-90 per cent of cases (Kiloh and Osselton 1961, Murphy et al 1967, Decker and Knott 1972. Fischgold et al (1961) mention that the EEG is often abnormal before signs of raised intracranial tension develop and also often before the neurological deficit is obvious.…”

Section: Discussionmentioning

confidence: 96%

“…In a few studies the various iavestigative techniques for localising brain tumours have been compared (Afifi et al 1965, Wang et al 1965, Murphy etal. 1967, Abraham and Chandy 1969and Decker and Knott 1972.…”

Section: Introductionmentioning

confidence: 98%

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Electroencephalography in intracranial space occupying lesions and a comparison of it with other investigative procedures

1973

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SummaryElectroencephalographic studies in 100 cases of intracranial space occupying ]esions are reported and the value of EEG is compared with other investigative procedures. With cerebral hemisphere lesions good localisation was possible in 82.5~o and latera]isation alone was possible in a further 13.9~o. In 66~o of the cases of third ventricle and posterior fossa tumours the EEGs were abnormal but definite localisation was not possible. With posterior fossa, third ventricle and sellar or suprasellar tumours, and with subdural haematomas, neuroradiological contrast studies gave better localisation than did EEGs. With meningiomas the brain scan proved to be a more reliable investigative procedure than electroencephalography. With astrocytomas Grs. III and IV, even though EEG was always abnormal, good localisation was possible in only 77.8~o. trIowever, with low grade gliomas EEG gave positive results more often than did the brain scan. An EEG pattern suggestive of an acutely destructive lesion was noted in 94.5~o of the cases of astrocytoma Grs. III and IV, in 100~ of the eases of cerebral abscess, and in 66~o of the cases of cerebral metastasis. An EEG pattern suggestive of a slow growing lesion was noted in 83.3~o of the granulomas, 77~o of the less malignant gliomas, and 71.5% of the meningiomas.

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Herdstörungen

Zschocke¹

2002

Klinische Elektroenzephalographie

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The EEG in intrinsic supratentorial brain tumors: A comparative evaluation

Cited by 30 publications

References 9 publications

The role of biomarkers and MEG-based imaging markers in the diagnosis of post-traumatic stress disorder and blast-induced mild traumatic brain injury

The role of biomarkers and MEG-based imaging markers in the diagnosis of post-traumatic stress disorder and blast-induced mild traumatic brain injury

Electroencephalography in intracranial space occupying lesions and a comparison of it with other investigative procedures

Herdstörungen

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