The effect of 1-(4-metoxyphenyl)-5-{2-[4-(4-metoxyphenyl) piperazine-1-yl]-2-oxoethyl}-1,5-dihydro-4Hpyrazole[ 3,4-D] pyrydine-4-one and sodium valproate on the level of inhibitory and excitatory neurotransmitters in the brain in the hemispheric asymmetry
Abstract:Epilepsy affects about 1 % of the world population. Recently, epileptology considers the cerebral hemispheres (CH) as separate components, which differ due to the neurochemical hemisphere asymmetry. Aim. To study the level of neurotransmitters and their correlation in the CH of mice receiving 1-(4-metoxyphenyl)-5-{2-[4-(4-metoxyphenyl) piperazine-1-yl]-2-oxoethyl}-1,5-dihydro-4H-pyrazole[3,4-D]pyrydine-4-one (compound 78553) and sodium valproate in intact animals, and the pentylenetetrazol kindling model. Mate… Show more
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