The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients

Menon, Shruti; Nasir, Bushra; Avgan, Nesli; Ghassabian, Sussan; Oliver, Christopher; Lea, Rodney Arthur; Smith, Maree T.; Griffiths, Lyn R.

doi:10.1186/s10194-016-0652-7

Cited by 37 publications

(41 citation statements)

References 45 publications

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“…This effect was most pronounced in the C allele carriers of the MTHFR gene variant. Another study found that supplementation with a 1 mg dosage of folate and other B vitamins did not reduce headache outcome measures, which could indicate that high doses of folate acid are needed to see a clinical effect . Therefore, there may be certain subgroups of persons with migraine that might benefit from a high folate diet and/or supplements that contain moderate to high amounts of folate and vitamins B12 and B6.…”

Section: High Folate Dietsmentioning

confidence: 99%

Diet and Headache: Part 2

Martin

Vij

2016

Headache

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Section: High Folate Dietsmentioning

confidence: 99%

Diet and Headache: Part 2

Martin

Vij

2016

Headache

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“…It was shown that MMA was remarkably higher in migraine patients than controls (mean values were 1.39 vs 1.01 µg/dL, respectively). [41][42][43][44][45] However, it has been suggested migraineurs might be at a higher risk for having a lower concentration of vitamin B12 due to higher prevalence of GI disorders and chronic NSAIDs consumption 17 that can impair intrinsic factor production and vitamin B12 absorption. 13,14 Consequently, vitamin B12 deficiency/insufficiency can cause dysfunction of methionine metabolism pathway that is highly dependent on appropriate concentrations of B12.…”

Section: Discussionmentioning

confidence: 99%

“…[30][31][32][33] Furthermore, there is a considerable body of literature on decreased magnesium levels especially during ictal phases in migraine suffers when comparing to healthy individuals. [34][35][36] Moreover, it has been demonstrated that supplementation with vitamin B2, 37-40 B9, B6, [41][42][43][44][45] vitamin D, [46][47][48] and magnesium [49][50][51] could attenuate migraine features.…”

Section: Discussionmentioning

confidence: 99%

“…14,41 This hypothesis can be further supported by a few clinical trials that have shown the positive effects of a combination of vitamin B groups including B6, B9, and B12 on migraine characteristics especially through reducing Hcy serum concentration. [41][42][43][44][45] However, it has been suggested migraineurs might be at a higher risk for having a lower concentration of vitamin B12 due to higher prevalence of GI disorders and chronic NSAIDs consumption 17 that can impair intrinsic factor production and vitamin B12 absorption. 16 Although there are limited studies providing information on serum B12 levels in relation to migraine, present findings corroborate the ideas of Pizza et al, who demonstrated the possible link between a fall in serum B12 and migraine in 70 patients and improvement in migraine associated features after correction of vitamin B12 levels.…”

Section: Discussionmentioning

confidence: 99%

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Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case‐Control Study

et al. 2019

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Background Although the exact pathophysiological mechanistic pathways that result in the initiation of migraine attacks remain unclear, there are some proposed mechanisms including neurogenic inflammation, trigeminovascular system activation, vascular dysfunction, and augmented release of nitric oxide (NO) and homocysteine (Hcy). Vitamin B12 is thought to be involved in important pathways that seem to be related to the pathogenesis of migraine including scavenging against NO and prevention of hyperhomocysteinemia. Therefore, the aim of the current study was to evaluate the serum vitamin B12 and methylmalonic acid (MMA) status in a group of migraine patients compared to healthy controls. Methods After the recruitment of cases and controls, demographic data and migraine characteristics (including the number of headache days, severity of headaches, and duration of each attack in hours) were recorded. Serum vitamin B12 and MMA levels were measured using the enzyme‐linked immunosorbent assay technique. Results Seventy migraine patients and 70 healthy subjects were enrolled in this case control study. The serum levels of B12 were found to be significantly lower in migraine patients than in healthy subjects (512 ± 300 vs 667 ± 351 pg/mL, P = .007); whereas migraineurs had higher levels of MMA than controls (1.39 [0.59,4.01] vs 1.01 [0.49,1.45] µg/dL, P = .027). In the fully adjusted multiple regression model, those in the highest vs the lowest serum B12 quartile had 80% decrease in the odds of having migraine ([OR = 0.20, 95% CI = 0.05‐0.73], [P for trend = .008]); while, patients in the highest quartile of MMA had more than 5 times increased risk of having migraine ([OR = 5.44, 95% CI = 1.49‐19.87] [P for trend = .002]). There was no association between serum B12 and MMA levels and headache characteristics. Conclusion Taken together, these findings suggest that participants with lower vitamin B12 and higher MMA levels that considered as lower functional activity of B12 had higher odds of migraine.

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“…It found no significant improvement in headache disability, frequency, or severity from baseline to completion of treatment compared with placebo using the Migraine Disability Assessment Score (MIDAS). 60 Butterbur, or Petasites hybridus, has a long and complex history of use in headache. Although butterbur reduces the frequency of headache in patients in RCTs, 61 50 An RCT in 60 patients with migraine with or without aura compared yoga practice five days a week for six weeks with conventional care control.…”

Section: Safetymentioning

confidence: 99%

Complementary and integrative medicine in the management of headache

Millstine

Chen

Bauer

2017

BMJ

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Headaches, including primary headaches such as migraine and tension-type headache, are a common clinical problem. Complementary and integrative medicine (CIM), formerly known as complementary and alternative medicine (CAM), uses evidence informed modalities to assist in the health and healing of patients. CIM commonly includes the use of nutrition, movement practices, manual therapy, traditional Chinese medicine, and mind-body strategies. This review summarizes the literature on the use of CIM for primary headache and is based on five meta-analyses, seven systematic reviews, and 34 randomized controlled trials (RCTs). The overall quality of the evidence for CIM in headache management is generally low and occasionally moderate. Available evidence suggests that traditional Chinese medicine including acupuncture, massage, yoga, biofeedback, and meditation have a positive effect on migraine and tension headaches. Spinal manipulation, chiropractic care, some supplements and botanicals, diet alteration, and hydrotherapy may also be beneficial in migraine headache. CIM has not been studied or it is not effective for cluster headache. Further research is needed to determine the most effective role for CIM in patients with headache.

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The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients

Cited by 37 publications

References 45 publications

Diet and Headache: Part 2

Diet and Headache: Part 2

Serum Vitamin B12 and Methylmalonic Acid Status in Migraineurs: A Case‐Control Study

Complementary and integrative medicine in the management of headache

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