2010
DOI: 10.1016/j.biomaterials.2010.03.024
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The effect of 3D hydrogel scaffold modulus on osteoblast differentiation and mineralization revealed by combinatorial screening

Abstract: Cells are known to sense and respond to the physical properties of their environment and those of tissue scaffolds. Optimizing these cell-material interactions is critical in tissue engineering. In this work, a simple and inexpensive combinatorial platform was developed to rapidly screen three-dimensional (3D) tissue scaffolds and was applied to screen the effect of scaffold properties for tissue engineering of bone. Differentiation of osteoblasts was examined in poly(ethylene glycol) hydrogel gradients spanni… Show more

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Cited by 270 publications
(255 citation statements)
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“…[1][2][3][4][5][6] Bone is the most implanted tissue after blood. 7 Nearly seven million bone fractures occur annually in the United States alone.…”
mentioning
confidence: 99%
“…[1][2][3][4][5][6] Bone is the most implanted tissue after blood. 7 Nearly seven million bone fractures occur annually in the United States alone.…”
mentioning
confidence: 99%
“…Chatterjee et al fabricated macroporous3D scaffolds with varying chemical compositions were formed via salt leaching and were used to examine the response of osteoblasts to chemical composition in 3D [7]. The same group also developed apoly (ethylene glycol) dimethacrylate hydrogel system was used to encapsulate osteoblasts and examine the effect of scaffold modulus [8]. Hydrogels were also utilised by Yang et al to study the effect of different ECM proteins on embryonic stem cell differentiation [9].…”
Section: Screening In 3dmentioning
confidence: 99%
“…Due to their rich water content and polymeric structure, hydrogels can mimic the physiological environments to support long-term survival of numerous cell types [1][2][3][4] and can provide three-dimensional frameworks to direct cellular behaviors and interactions. [5][6][7] Polyethylene glycol (PEG) is a synthetic bioinert polymer that has no innate cell adhesiveness and biological activity; however, PEG can be easily functionalized with bioactive peptide sequences or proteins, such as RGD or BMP-2, to present biological cues and stimulate cell behaviors. 8,9 Inclusion of cell process-catalyzed degradable crosslinking molecules, such as matrix metalloprotease (MMP)-sensitive peptides, can further promote the remodeling of the basic PEG polymeric structures and mediate native cellular matrix deposition.…”
Section: Introductionmentioning
confidence: 99%