The effect of 5,7-dihydroxytryptamine on peripheral adrenergic nerves in the mouse

Hg, Baumgarten; Hp, Groth; Göthert, M.; Aa, Manian

doi:10.1007/bf00501233

Cited by 10 publications

(2 citation statements)

References 15 publications

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“…administration of 5,7-DHT in rats submitted to the formalin test Endogenous spinal 5-HT was depleted via the i.t. injection of 5,7-DHT as previously described (Baumgarten et al, 1974). Cannulated animals received an injection of desipramine (25 mg/kg, i.p.…”

Section: Spinal Surgerymentioning

confidence: 99%

Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT4, 5-HT6 and 5-HT7 receptors

et al. 2012

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Section: Spinal Surgerymentioning

confidence: 99%

Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT4, 5-HT6 and 5-HT7 receptors

et al. 2012

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“…The question was whether the neurotoxins also affect noradrenergic neurones. In rodents, intraperitoneally administered 5,7-DHT destroyed the postganglionic sympathetic neurones with a potency comparable to that of 6-hydroxydopamine, the standard neurotoxin for noradrenergic neurones (Baumgarten et al 1974 ), whereas 5,6-DHT showed such an effect at high doses only (Baumgarten et al 1972a ). Subsequently, the complexity of acute effects of 5-HT and its monohydroxylated and dihydroxylated analogs on cardiovascular parameters was studied in vitro, in situ, and in vivo.…”

Section: Serotoninmentioning

confidence: 99%

Serotonin and beyond—a tribute to Manfred Göthert (1939-2019)

Bönisch

Fink

Malinowska

et al. 2021

Naunyn-Schmiedeberg's Arch Pharmacol

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Manfred Göthert, who had served Naunyn-Schmiedeberg’s Arch Pharmacol as Managing Editor from 1998 to 2005, deceased in June 2019. His scientific oeuvre encompasses more than 20 types of presynaptic receptors, mostly on serotoninergic and noradrenergic neurones. He was the first to identify presynaptic receptors for somatostatin and ACTH and described many presynaptic receptors, known from animal preparations, also in human tissue. In particular, he elucidated the pharmacology of presynaptic 5-HT receptors. A second field of interest included ligand-gated and voltage-dependent channels. The negative allosteric effect of anesthetics at peripheral nACh receptors is relevant for the peripheral clinical effects of these drugs and modified the Meyer-Overton hypothesis. The negative allosteric effect of ethanol at NMDA receptors in human brain tissue occurred at concentrations found in the range of clinical ethanol intoxication. Moreover, the inhibitory effect of gabapentinoids on P/Q Ca2+ channels and the subsequent decrease in AMPA-induced noradrenaline release may contribute to their clinical effect. Another ligand-gated ion channel, the 5-HT3 receptor, attracted the interest of Manfred Göthert from the whole animal via isolated preparations down to the cellular level. He contributed to that molecular study in which 5-HT3 receptor subtypes were disclosed. Finally, he found altered pharmacological properties of 5-HT receptor variants like the Arg219Leu 5-HT1A receptor (which was also shown to be associated with major depression) and the Phe124Cys 5-HT1B receptor (which may be related to sumatriptan-induced vasospasm). Manfred Göthert was a brilliant scientist and his papers have a major impact on today’s pharmacology.

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Neurotoxic Phenylalkylamines and Indolealkylamines

Baumgarten¹,

Zimmermann²

1994

Selective Neurotoxicity

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The effect of 5,7-dihydroxytryptamine on peripheral adrenergic nerves in the mouse

Cited by 10 publications

References 15 publications

Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT4, 5-HT6 and 5-HT7 receptors

Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT4, 5-HT6 and 5-HT7 receptors

Serotonin and beyond—a tribute to Manfred Göthert (1939-2019)

Neurotoxic Phenylalkylamines and Indolealkylamines

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