The effect of a cobra venom factor on complement and adjuvant‐induced disease in rats

Kourounakis, L.; Nelson, Robert A.; Kupusta, M A

doi:10.1002/art.1780160111

Cited by 27 publications

(10 citation statements)

References 18 publications

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“…Depletion of C3 by CoF delayed the onset of arthritis in these animals until the C3 levels were returning toward normal values (32). At moderate doses, with 20% complement suppression, CoF was ineffective in inhibiting bovine serum albumin antigen-induced arthritis in New Zealand white rabbits (33).…”

Section: Discussionmentioning

confidence: 93%

The effects of a partially purified fraction of an ant venom in rheumatoid arthritis

Altman

Schultz

Collins‐Yudiskas

et al. 1984

Arthritis & Rheumatism

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A partially purified extract of an ant venom from the South American tree ant Pseudomyrmex sp. was tested in a double-blind, controlled study of patients with rheumatoid arthritis. Venom treated patients demonstrated an improvement in global efficacy and a decrease in the number of tendedpainful joints and swollen joints. Swollen joint index improved in 60% of venom treated patients. Other parameters did not demonstrate significant change. Reduction of joint swelling was followed by symptomatic improvement that was sometimes delayed by weeks. Reactions were limited to erythema at the injection site (all patients), local pruritis (two-thirds of the patients), and fever with malaise (onethird of the patients). Further study of this venom in rheumatoid arthritis appears warranted in view of its apparent favorable efficacy-to-toxicity ratio.Some animal products have been thought to have special curative powers (1). In general, the use of venoms is recent (i.e., the past 200 years) (2). Viper venoms, particularly cobra, and honeybee venoms have been the most popular. Despite episodic empha-

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Section: Discussionmentioning

confidence: 93%

The effects of a partially purified fraction of an ant venom in rheumatoid arthritis

Altman

Schultz

Collins‐Yudiskas

et al. 1984

Arthritis & Rheumatism

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“…Complement depletion by cobra venom in Freund's adjuvant arthritis in rats delays the onset of arthritis in these animals (Kourounakis, Nelson, and Kupusta, 1973). Whether the relatively low numbers of animals having arthritis in our work compared with the Warren model is due to the complement deficiency, we are unable to state at present.…”

Section: Discussionmentioning

confidence: 64%

Arthritis, deformities, and runting in C5-deficient mice injected with human rheumatoid arthritis synovium

Crocker¹,

Ghose²,

Rozee³

et al. 1974

J Clin Pathol

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The pathogenesis of rheumatoid arthritis might be more easily understood and the efficacy of therapeutic measures might be more accurately assessed if a convenient animal replica of this disease were available for laboratory study. Intraperitoneal injection of homogenates of inflamed synovium taken at operation from patients with rheumatoid arthritis produces inflammatory swelling and deformity in the tail and extremities of a proportion of injected mice from a complement (C5)-deficient inbred strain. Swelling of the paws leads to limping of the affected mice. The lesions are transmissible from generation to generation. The results support the theory of a transmissible agent in the inflamed synovium of rheumatoid arthritis patients.

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“…Humoral involvement of anti-mycobacterial antibody has been described [6], and the delayed development of adjuvant arthritis after treatment with cobra venom factor [32] also suggests a role for humoral immunity in this model. However, WALZ et al [33] reported that decomplementation with cobra venom factor had no effect on the onset of inflammation in adjuvant arthritis.…”

Section: Discussionmentioning

confidence: 98%

The absence of antibodies to type II collagen in established adjuvant arthritis in rats

et al. 1984

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Utilizing an adjuvant arthritis model in rats, we examined humoral immunity to collagen and inflammation in animals with active disease and during drug therapy. Humoral immunity to types I or II collagen was not detected in the sera of rats with advanced adjuvant arthritis; this was in marked contrast to rats with type II collagen-induced arthritis which possessed serum antibodies to native and denatured type II collagen. Hind paw edema and bone pathology were monitored as parameters of inflammation. A new investigational drug, Wy-41,770, was most effective in reducing all of these aspects of inflammatory disease while indomethacin, methylprednisolone, and D-penicillamine caused a less significant diminution of only some of these parameters of inflammation. Antibodies to collagen were not detected in the sera of rats treated with the drugs under study. These data demonstrate that adjuvant arthritis can occur in rats in the absence of antibodies to types I or II collagen.

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The effect of a cobra venom factor on complement and adjuvant‐induced disease in rats

Cited by 27 publications

References 18 publications

The effects of a partially purified fraction of an ant venom in rheumatoid arthritis

The effects of a partially purified fraction of an ant venom in rheumatoid arthritis

Arthritis, deformities, and runting in C5-deficient mice injected with human rheumatoid arthritis synovium

The absence of antibodies to type II collagen in established adjuvant arthritis in rats

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