The effect of a collagen dressing on contaminated surgical wounds in rats

Abstract

In maintaining the rat, the collagen dressings, Aviderm Amine and Aviderm, are as effective as skin in low bacterial levels in contaminated surgical wounds. In the scald-burn wound in the rat the effect of skin dressing is confirmed. Also, 48 h after collagen dressing in the wound the bacterial contamination was the same as that seen under autograft dressings. We have elsewhere suggested that skin and some other dressings modify the local host defense by their effect on the accumulated white blood cells. We believe that collagen, as well as some synthetics, can alter the local environment permitting the destruction of invading bacteria by the accumulated white blood cells.

Collagen sponge for leg ulcers

“…Collagen sponge has been reported to provide a suitable porous framework for permeation by fibroblasts (Gey era/., 1974;Leighton, Mark & Justh, 1968;Oluwasanmi & Chvapil, 1976), formation of capillaries and acceleration of wound healing (Nathan, Macmillan & Holder, 1974;Chvapil, 1977). It would appear that the pore size of the implanted material plays a crucial role in controlHng the rate of cell ingrowth.…”

“…Advances in our knowledge of collagen chemistry have recently led to the production of a variety of reconstituted collagen preparations which are finding widespread use in medicine. Reconstituted collagen has been produced in the form of solution, gels, fibres, tubes and sponges, and the medical applications of these preparations have ranged from plasma expanders and vaginal contraceptives to surgical prostheses and bone substitutes (Chvapil, Kronenthal & Van Winkel, 1973;Stenzel et ai, 1974;Chvapil, 1977)-Collagen sponge would on theoretical grounds appear to be ideal material for filling skin defects due to pressure sores and leg ulcers since it would provide a porous matrix for the permeation of fibroblasts. In this article we discuss the potential of collagen sponges in dermatology, and we report our experience in the preparation of such sponges and their preliminary use in the treatment of stasis ulcers of the leg.…”

Identification of Small Peptides of Acidic Collagen Extracts from Silver Carp Skin and Their Therapeutic Relevance

“…Reports [2][3][4][5][6] on the beneficial effects of collagen-containing products on wound healing unhealed for one year when other methods were used, but significant effects were achieved after three months of collagen gel applied directly to the wound twice a day.…”

In VivoPerformance of Chitosan/Soy-Based Membranes as Wound-Dressing Devices for Acute Skin Wounds

“…Indiscriminately, synthetic, [11][12][13][14] natural, 8,15,16 or biological materials 10,17,18 have been presented along the years, as the key elements for controlling/modulating the healing mechanisms and the outcomes of wound repair upon dressing. 10 Among the recently proposed natural-origin materials for wound dressing, collagen 2,9,19 chitosan, [20][21][22][23][24] and silk 25,26 occupy a central position due to their nature, which might present improved performance.…”

“…The traditional wound dressing that simply covered and protected the wound 2,3 has been replaced by alternative dressings that allow control of wound moisture [4][5][6][7] and, more recently, by dressings with an (bio-) active role in the healing environment. 8,9 However, most of the existing products need to be changed every few days after their application; in some cases, there is the need to replace the material to maintain/accelerate the ongoing healing process. 10 Therefore, further developments that facilitate the healing process or address issues such as the control of the chemical environment and bacterial infection are required and desired.…”