The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, insulin sensitivity and leucine kinetics in young men

Unni, Uma S.; Raj, Tony; Sucharita, S; Kuriyan, Rebecca; Uthappa, Sheila; Vaz, Mário; Regan, Meredith M.; Kurpad, Anura V

doi:10.1016/j.clnu.2012.03.008

Cited by 16 publications

(6 citation statements)

References 22 publications

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“…Other amino acids like lysine have been well-demonstrated to contribute to various health-promoting properties. Lysine enhances immune function by aiding in the formation of antibodies, improving stomach function, facilitating cell repair, participating in fatty acid metabolism, and enhancing calcium absorption [ 26 , 32 , 33 , 34 , 35 ]. In the current study, the bioavailability of lysine, which is typically limited in grains, showed a notable increase in the two quinoa seeds after the sprouting process.…”

Section: Discussionmentioning

confidence: 99%

Impact of Sprouting Process on the Protein Quality of Yellow and Red Quinoa (Chenopodium quinoa)

Barakat,

Al-Qabba,

Algonaiman

et al. 2024

Molecules

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The demand for plant-based proteins has increased remarkably over the last decade. Expanding the availability and variety of plant-based protein options has shown positive potential. This study aimed to investigate the qualitative and quantitative changes in amino acids of yellow and red quinoa seeds (YQ and RQ) during a 9-day germination period. The results showed that the germination process led to an increase in the total amino acids by 7.43% and 14.36% in the YQ and RQ, respectively. Both varieties exhibited significant (p < 0.05) increases in non-essential and essential amino acids, including lysine, phenylalanine, threonine, and tyrosine. The content of non-essential amino acids nearly reached the standard values found in chicken eggs. These results were likely attributed to the impact of the germination process in increasing enzymes activity and decreasing anti-nutrient content (e.g., saponins). A linear relationship between increased seeds’ hydration and decreased saponins content was observed, indicating the effect of water absorption in changing the chemical composition of the plant. Both sprouts showed positive germination progression; however, the sprouted RQ showed a higher germination rate than the YQ (57.67% vs. 43.33%, respectively). Overall, this study demonstrates that germination is a promising technique for enhancing the nutritional value of quinoa seeds, delivering sprouted quinoa seeds as a highly recommended source of high-protein grains with notable functional properties.

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Section: Discussionmentioning

confidence: 99%

Impact of Sprouting Process on the Protein Quality of Yellow and Red Quinoa (Chenopodium quinoa)

Barakat,

Al-Qabba,

Algonaiman

et al. 2024

Molecules

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“…In infancy, inadequate protein (based on animal studies) would be expected to affect growth of lean mass and length/ height, and in adults, functional studies such as those measuring glutathione homeostasis are relevant (Jackson et al, 2004). We have shown that muscle strength declines with low levels of lysine intake, and is improved when generous intakes of lysine are eaten over a longer period (3 weeks and 8 weeks, Kurpad et al, 2002;Unni et al, 2012). In addition, recent evidence on lower plasma amino acid levels in undernourished children is also indicative of the role amino acids may play in growth (Semba et al, 2016).…”

Section: Amino Acid Requirementmentioning

confidence: 91%

Recommended Dietary Allowances- Facts and Uncertainties

Kurpad¹

2016

Proceedings of the Indian National Science Academy

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For the purpose of evaluating diets of individuals and populations, the nutrient requirements were defined. Over the years, recommendations across several countries have evolved. In India the ICMR report has a single value for a particular population group while in other countries up to 4 values have been reported. Currently the commonly used definitions are for the average nutrient requirements, recommended nutrient intake or dietary allowances and the upper nutrient/tolerable upper limit. Using these requirement constructs, not only can the risk of inadequate intakes be calculated (using the probability approach) but the risk for excessive intakes that cross upper limit can also be determined. With the increase in consumption of packaged foods and fortification, there needs to be clarity on the upper limit of nutrients, particularly those that are stored in the body (e.g. iron), to prevent toxicity.Uncertainties regarding specific requirements and controversies still prevail. This is because the measurement of the daily requirement is very difficult when accurate measurements are to be made in controlled conditions or under various physiological states. These typically are measured as that intake which balances daily losses. Equally, robust nutrient intake data is also required to compute the risk of deficiency or excess.

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“…Among post-stroke sarcopenic patients, leucine-rich amino acid supplementation alongside low-intensity resistance exercises for 8 weeks duration demonstrated an improvement in muscle mass, strength, and physical functioning [ 89 ]. Healthy Indian adults, following 8-week long high lysine diet demonstrated a significant increase in upper limb muscle strength compared to group following a low lysine diet [ 90 ], however effect of the same on the elderly population has not been explored. An additional important component to consider in case of normal protein intake or protein supplementation is the aspect of distribution of the protein throughout the day.…”

Section: Role Of Macro and Micronutrients In Sarcopeniamentioning

confidence: 99%

“…Furthermore, the studies exploring the role of micronutrients in muscle health are limited and most of the available literature is on animal models and observational human studies. The number of studies exploring the role of nutrients in muscle health among the Indian population is extremely scarce as summarized in Table 2 [ 90 , [103] , [104] , [105] , [106] ]. Several micronutrients warrant further investigation in particular in this population as discussed in the next section of this review.…”

Section: Micronutrientsmentioning

confidence: 99%

“…The cholecalciferol dose was set at 60,000 IU/week for 8 weeks followed by fortnightly for 4 months, calcium carbonate consisting of 500 mg elemental calcium, twice daily. No significant effect observed on muscle strength Unni US et al., 2012 [ 90 ] Randomized controlled trial 40 young adults (18-35 years) divided equally into undernourished (UN) and well nourished (WN) based on BMI Participants from each group (UN and WN) were divided into either high lysine or low lysine diet. The high lysine group received 80 mg/kg/day lysine whereas the low lysine group received a range of 25–40 mg/kg/day of lysine.…”

Section: Micronutrientsmentioning

confidence: 99%

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Nutrition in the prevention and management of sarcopenia - A special focus on Asian Indians

Bhattacharya¹,

Bhadra²,

Schols³

et al. 2022

Osteoporosis and Sarcopenia

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The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, insulin sensitivity and leucine kinetics in young men

Cited by 16 publications

References 22 publications

Impact of Sprouting Process on the Protein Quality of Yellow and Red Quinoa (Chenopodium quinoa)

Impact of Sprouting Process on the Protein Quality of Yellow and Red Quinoa (Chenopodium quinoa)

Recommended Dietary Allowances- Facts and Uncertainties

Nutrition in the prevention and management of sarcopenia - A special focus on Asian Indians

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