The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis

Abstract

A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days. Initially, gingival health was established in 34 subjects following a 6-week period of professional tooth cleaning and oral hygiene instruction. A toothshield was constructed to fit 4 posterior mandibular teeth. Undiluted test or placebo dentifrice was applied to the experimental teeth via the toothshield, which also prevented plaque removal from these teeth during habitual brushing of the remainder of the dentition. The presence of plaque, bleeding after probing and visual signs of inflammation were independently assessed. Plaque accumulated rapidly and gingivitis developed in both groups. At the 2-wk assessments, lower mean plaque scores were recorded for the group using the test dentifrice. At the 4-wk assessment a significantly lower level of gingivitis was recorded for the test group. It is concluded that (a) the model can be used to establish the potential efficacy of a dentifrice to maintain gingival health, (b) the dentifrice containing zinc citrate and Triclosan was efficacious and (c) the Gingival Index possibly overestimates the proportion of healthy gingival sites.

Comparative efficacy of two daily use mouthrinses: randomized clinical trial using an experimental gingivitis model

“…The baseline examinations consisted of a complete intraoral examination, assessment of gingivitis using the Modified Gingival Index 17 followed by sulcular bleeding, 18 and Plaque Index using the Turesky modification of the Quigley-Hein Plaque Index. 19 Following the baseline examination, qualifying subjects received a complete dental prophylaxis to remove all stain, plaque, and calculus.…”

“…18 The secondary outcome variable was gingival bleeding, (Gingival Bleeding Index). 19 At baseline, the three treatment groups were compared with respect to age, mean Modified Gingival Index, mean Plaque Index, and mean Gingival Bleeding Index by means of a one-way analysis of A sample size of 135 (45 per treatment group) completed subjects was calculated to provide power of 0.90 for detecting a difference of 10% and 5% between treatment groups in mean plaque and gingival index scores, respectively.…”

The Influence of Text Message Reminders on Oral Hygiene Compliance in Orthodontic Patients

“…The BI was scored as described by Saxton and van der Ouderaa (26) upon probing the mesio-buccal, direct buccal and disto-buccal aspects of the gingival sulci of the Ramfjord teeth. BI scoring is described in Table 1.…”

Stabilized Stannous Fluoride Dentifrice as a Dental Plaque Inhibitor and an Antigingivitis Agent: Meta-Analysis

“…Czasami wykorzystywano obrazowanie cyfrowe za pomocą DPIS ( Digital Plaque Imaging System) w celu porów-nania formowania się płytki nazębnej przez noc (pomiar ranny) lub 24 godziny później [11]. W ocenach klinicznych przeciwzapalnego dzia-łania tej pasty stosowano wskaźnik GI wg Löe i Silnessa [12], GBI wg Saxtona i van der Ouderaa [13] i najczęściej zmodyfikowany przez Lobene et al [14] wskaźnik dziąsłowy (MGI).…”