Objective: To explore the impact of an empowerment-based health management program, implemented within a medical consortium framework, on secondary prevention for stroke patients. Methods: Stroke patients admitted to our hospital and its medical group were included in the study. They were randomly divided into two groups: a control group of 98 cases and an experimental group of 101 cases. The control group received conventional treatment and nursing propaganda and education, while the experimental group received an empowerment-based health management program within the medical consortium framework. Stroke recurrence hospitalization rates, self-efficacy scale scores, stroke patient empowerment nursing assessment scale scores, and medication adherence between the two groups were analyzed and compared. Results: After six months, the stroke recurrence hospitalization rate was significantly higher in the control group than in the experimental group (P<0.05). The experimental group demonstrated significantly higher self-efficacy scores than the control group (P<0.05). The stroke patient empowerment nursing assessment scale scores in the experimental group increased (P<0.05). The experimental group showed higher Patient Activation Measure (PAM) scores compared to the control group (P<0.05). The experimental group exhibited higher Medication Adherence Scale-8 (MMAS-8) scores compared to the control group (P<0.05). Conclusion: The empowerment-based health management program within the medical consortium framework effectively enhances secondary prevention outcomes for stroke patients. Through the integration of healthcare resources, provision of personalized health management plans, and reinforcement of patient education, this program enhances patients' self-management capabilities, promotes medication adherence, and encourages positive lifestyle changes. As a result, it reduces the recurrence rate of strokes and the risk of complications. The empowerment-based health management program within the medical consortium framework holds significant potential for enhancing chronic disease management.