The effect of a fibrin glue on the integration of Bio‐Oss<sup>®</sup> with bone tissue

Carmagnola, Daniela; Berglundh, Tord; Lindhe, Jan

doi:10.1034/j.1600-051x.2002.290501.x

Cited by 101 publications

(90 citation statements)

References 17 publications

(15 reference statements)

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“…Bio-Oss has been proposed as a biocompatible graft material for bony defects for it has shown osteoconductive properties -that is, it was replaced with newly formed bone after grafting [18][19][20] . However, regarding the resorption of Bio-Oss, contradicting reports have emerged.…”

Section: Discussionmentioning

confidence: 99%

The bone-healing effect of a xenograft in a rat calvarial defect model

2009

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Bone grafts have been widely used to fill osseous defects in medicine, dentistry, and periodontology. The purpose of this study was to investigate the effects of a xenograft (Unilab Surgibone ® ) on experimentally created parietal bone defects in rats. To this end, 14 rats were employed in the present study and in each of them, 5-mm-diameter defects were created on the parietal bone. The right defect sites were filled with the xenograft material, while the left sites were used as control. After 30 days, the rats were sacrificed and tissue samples were retrieved from the defect sites of the cranium. Dense collagenous tissue was observed in the control area, whereas the xenograft particles were surrounded by a fibrous tissue layer at the implantation site. Based on the findings obtained, it could be concluded that the investigated xenograft seemed biocompatible and could be proposed as a potential material for filling osseous defects.

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Section: Discussionmentioning

confidence: 99%

The bone-healing effect of a xenograft in a rat calvarial defect model

2009

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“…Besides, in contrast to Bio-Oss alone group, no soft connective tissue replacement with newly formed bone was observed in Bio-Oss/fibrin treated defects. 142 A fibrin sealant was also reported to inhibit bone induction in the abdominal muscles of rats when used in combination with demineralized bone particles. The inhibited bone formation was perhaps due to the immunological response to xenogeneic proteins (fibrinogen and thrombin were from humans and aprotinin was of bovine origin).…”

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confidence: 99%

“…141 As mentioned earlier, some researchers noted a negative impact of fibrin on bone repair. For example, Carmagnola et al 142 noted that adding fibrin to Bio-Oss particles resulted in 4 times less tissue contact between bone and biomaterials in mandibular defects of dogs. Besides, in contrast to Bio-Oss alone group, no soft connective tissue replacement with newly formed bone was observed in Bio-Oss/fibrin treated defects.…”

mentioning

confidence: 99%

A review of fibrin and fibrin composites for bone tissue engineering

Noori

Ashrafi

Vaez-Ghaemi

et al. 2017

IJN

377

256

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Tissue engineering has emerged as a new treatment approach for bone repair and regeneration seeking to address limitations associated with current therapies, such as autologous bone grafting. While many bone tissue engineering approaches have traditionally focused on synthetic materials (such as polymers or hydrogels), there has been a lot of excitement surrounding the use of natural materials due to their biologically inspired properties. Fibrin is a natural scaffold formed following tissue injury that initiates hemostasis and provides the initial matrix useful for cell adhesion, migration, proliferation, and differentiation. Fibrin has captured the interest of bone tissue engineers due to its excellent biocompatibility, controllable biodegradability, and ability to deliver cells and biomolecules. Fibrin is particularly appealing because its precursors, fibrinogen, and thrombin, which can be derived from the patient’s own blood, enable the fabrication of completely autologous scaffolds. In this article, we highlight the unique properties of fibrin as a scaffolding material to treat bone defects. Moreover, we emphasize its role in bone tissue engineering nanocomposites where approaches further emulate the natural nanostructured features of bone when using fibrin and other nanomaterials. We also review the preparation methods of fibrin glue and then discuss a wide range of fibrin applications in bone tissue engineering. These include the delivery of cells and/or biomolecules to a defect site, distributing cells, and/or growth factors throughout other pre-formed scaffolds and enhancing the physical as well as biological properties of other biomaterials. Thoughts on the future direction of fibrin research for bone tissue engineering are also presented. In the future, the development of fibrin precursors as recombinant proteins will solve problems associated with using multiple or single-donor fibrin glue, and the combination of nanomaterials that allow for the incorporation of biomolecules with fibrin will significantly improve the efficacy of fibrin for numerous bone tissue engineering applications.

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“…Another xenogeneic, bone-derived implant material is Bio-Oss, which is similar to the xenograft investigated in our studies (Develioglu et al2009(Develioglu et al , 2010. Bio-Oss has been proposed as a biocompatible graft material for bony defects for it has shown osteoconductive properties -that is, it was replaced with newly formed bone after grafting (Yıldırım et al, 2001, Sculean et al, 2002, Carmagnola et al, 2002. However, regarding the resorption of Bio-Oss, contradicting reports have emerged.…”

Section: Bioactive Ceramic Biomaterialsmentioning

confidence: 76%

Histopatological Effect Characteristics of Various Biomaterials and Monomers Used in Polymeric Biomaterial Production

Saraydın¹,

Saraydın²

2011

Biomaterials - Physics and Chemistry

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The effect of a fibrin glue on the integration of Bio‐Oss^® with bone tissue

Abstract: The adjunct of Tisseel may jeopardize the integration of Bio-Oss particles with bone tissue.

Cited by 101 publications

References 17 publications

The bone-healing effect of a xenograft in a rat calvarial defect model

The bone-healing effect of a xenograft in a rat calvarial defect model

A review of fibrin and fibrin composites for bone tissue engineering

Histopatological Effect Characteristics of Various Biomaterials and Monomers Used in Polymeric Biomaterial Production

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The effect of a fibrin glue on the integration of Bio‐Oss® with bone tissue

Abstract: The adjunct of Tisseel may jeopardize the integration of Bio-Oss particles with bone tissue.

Cited by 101 publications

References 17 publications

The bone-healing effect of a xenograft in a rat calvarial defect model

The bone-healing effect of a xenograft in a rat calvarial defect model

A review of fibrin and fibrin composites for bone tissue engineering

Histopatological Effect Characteristics of Various Biomaterials and Monomers Used in Polymeric Biomaterial Production

Contact Info

Product

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The effect of a fibrin glue on the integration of Bio‐Oss^® with bone tissue