The effect of a fortified milk drink on vitamin D status and bone turnover in post-menopausal women from South East Asia

Kruger, Marlena C.; Schollum, Linda M.; Kuhn-Sherlock, B.; Hestiantoro, Andon; Wijanto, P.; Li-Yu, Julie; Angeles‐Agdeppa, Imelda; Todd, Joanne M.; Eastell, Richard

doi:10.1016/j.bone.2009.10.036

Cited by 58 publications

(33 citation statements)

References 49 publications

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“…Even though the change in vitamin D status was small, it did indicate that supplementation with vitamin D would be of benefit over a longer period of time, and therefore contributing to improvement of bone health. 6,[8][9][10]14 Vitamin D insufficiency increases PTH levels, and chronically elevated PTH levels will increase bone turnover and especially cortical bone loss. 16 Furthermore, several studies in postmenopausal women have reported not only an inverse relationship between 25 (OH)D and PTH but also with BMD.…”

Section: Discussionmentioning

confidence: 99%

“…In South East Asian postmenopausal women, fortified milk rapidly reduced bone resorption and bone turnover markers within weeks of starting supplementation. 14 We aimed to evaluate the impact of a high-calcium vitamin D fortified milk (HCM) intervention in women potentially at risk of developing osteoporosis due to low calcium intakes and vitamin D deficiency, but in whom marker levels are closer to the reference ranges for postmenopausal women. We hypothesised that bone resorption will reduce significantly within the 12 weeks of supplementation, as measured by serum C-telopeptide (CTX) coinciding with a reduction in plasma parathyroid hormone (PTH) levels and that there would be an improvement in vitamin D status.…”

Section: Introductionmentioning

confidence: 99%

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High-calcium, vitamin D fortified milk is effective in improving bone turnover markers and vitamin D status in healthy postmenopausal Chinese women

Kruger

Todd

et al. 2012

Eur J Clin Nutr

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BACKGROUND/OBJECTIVES: Risk for developing osteoporosis increases in Asia. The purpose of the study was to evaluate the impact of a high-calcium vitamin D fortified milk (HCM) intervention on parathyroid hormone (PTH) levels, vitamin D status and markers of bone turnover in postmenopausal Chinese women. SUBJECTS/METHODS: Sixty three women (455 years) were assigned to receive two servings of either a calcium/vitamin D fortified milk or a control drink for 12 weeks. PTH, serum 25 (OH)D levels, C-telopeptide of type I collagen (CTX) levels and procollagen type I N-terminal propeptide (PINP) were measured at baseline, 2, 8 and 12 weeks of supplementation. RESULTS: Daily calcium intake at baseline ranged between 260 and 482 mg for the HCM, and 252 and 692 mg for the control group. HCM improved serum 25 (OH)D levels significantly (33.13-39.49 nmol/l), while remaining similar in the control group (29.27-28.21 nmol/l). The difference between the groups were significant at week 2, 8 and 12. The percentage change in PTH levels in the HCM group was significant from week 2 onwards compared to the control drink (Po0.017, Po0.05 and Po0.001 at weeks 2, 8 and 12, respectively). Plasma CTX of the HCM group reduced by 25% between weeks 0 and 2, remaining significantly lower and at similar levels up to week 12. The difference between the HCM and control group for PINP reached significance at weeks 8 (P ¼ 0.011) and 12 (P ¼ 0.003). CONCLUSIONS: The HCM intervention significantly improved vitamin D status and reduced bone turnover over 12 weeks in postmenopausal Chinese women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High-calcium, vitamin D fortified milk is effective in improving bone turnover markers and vitamin D status in healthy postmenopausal Chinese women

Kruger

Todd

et al. 2012

Eur J Clin Nutr

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“…A high-calcium milk drink with added vitamin D, magnesium, and zinc was compared with a placebo (Kruger et al, 2010). The high-calcium milk drink significantly improved vitamin D status and decreased bone turnover in 2 groups of Southeast Asian women.…”

Section: Fortified Dairy Productsmentioning

confidence: 99%

Invited review: Dairy intake and bone health: A viewpoint from the state of the art

Caroli

Poli²,

Ricotta

et al. 2011

Journal of Dairy Science

143

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“…A hosszabb időtartamú tanulmányokban leírták a csontásványianyagok növekedését a csípőízületekben, de a gerincben nem [18,19,20]. A Framingham tanulmányban joghurt fogyasztása mellett csökkent a csipőtörések kockázata [2].…”

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A laktózintoleranciáról: Múlt és jelen – II. rész

Buzás¹

2015

Orvosi Hetilap

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A szerző a laktózintolerancia, a kalcium-és D-vitamin-anyagcsere és az osteoporosis összefüggéseit foglalja össze. A laktózintolerancia egyes betegcsoportokban fokozza az alkar-és csípőtörések kockázatát. Néhány népcsoportban összefüggés van a laktázgén genotípusa és a töréskockázat között. A kalcium-és D-vitamin-pótlás növeli a csontok ásványianyag-mennyiségét, ezért e vitaminok fogyasztása indokolt gyermekeknél, terhességben, a szoptatás alatt, illetve a menopauza után. A tej és tejtermékek fogyasztása növelheti a petefészekrák kockázatát. Finneknél a laktázgén CC genotípusa növelte, brit, spanyol és olasz egyéneknél nem befolyásolta a colorectalis rák kockázatát. Egyéni érzé-kenység alapján a gyógyszerekben lévő kis mennyiségű (10-750 mg) laktóz is okozhat tüneteket. A közhiedelemmel és a reklámmal ellentétben a kontrollált tanulmányok sem a diéta, sem az enzimpótlás, sem a probiotikumok hatását nem igazolták az evidenciák színvonalán. Mivel elfogadott irányelvek nincsenek, a tejcukor-érzékenység egyénre szabott terápiája választandó. A fokozódó érdeklődés ellenére a laktózintoleranciában még sok ismeretlen tényező hatá-sát kell tovább kutatni. Orv. Hetil., 2015, 156(43), 1741-1749. Kulcsszavak: daganatok, enzimpótlás, laktóz, osteoporosis, probiotikumokLactose intolerance: past and present. Part II The author summarises the interrelations between lactose intolerance, calcium and vitamin D metabolism and osteoporosis. Lactose intolerance enhances the risk of forearm and hip fractures in some patients. Lactase gene genotype and fracture risk are related in some populations. Calcium and vitamin D supplementation increase bone mineral content and they are justifi ed in children, during pregnancy and lactation, and in postmenopausal women. The intake of milk and milk products could increase the risk of ovarian carcinoma. CC genotype of the lactase gene increased the risk of colorectal carcinoma in Finns; no such effect was observed in British, Spanish and Italian patients. Even small quantities of lactose in drugs (10-750 mg) could elicit intolerance symptoms due to individual susceptibility. In spite of public knowledge and advertising, controlled studies did not prove the benefi cial effect of either a lactosefree diet, enzyme supplementation or probiotics in an evidence-based manner. While accepted guidelines are lacking, a personalised therapy is mandatory. In spite of increasing public interest in lactose intolerance, many unknown factors must still be studied. Rövidítések 5-FU = 5-fl uorouracil; CFU = (colony forming unit) telepkép-ző egység; CRC = colorectalis carcinoma; DEXA = dual energy X-ray absorbtiometry; DM = diabetes mellitus; IGF-1 = inzulinszerű növekedési faktor 1-es típus; KT = konfi denciatartomány; LI = laktózintolerancia; NIH = National Institute of Health; OÉTI = Országos Élelmezés-és Táplálkozástudomá-nyi Intézet; OGYI: Országos Gyógyszerészeti Intézet; OR = (odds ratio) esélyhányados; RR = relatív kockázat; UDP = uridinil-difoszfát A laktózintolerancia (LI) széles körű elterjedése révén h...

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The effect of a fortified milk drink on vitamin D status and bone turnover in post-menopausal women from South East Asia

Cited by 58 publications

References 49 publications

High-calcium, vitamin D fortified milk is effective in improving bone turnover markers and vitamin D status in healthy postmenopausal Chinese women

High-calcium, vitamin D fortified milk is effective in improving bone turnover markers and vitamin D status in healthy postmenopausal Chinese women

Invited review: Dairy intake and bone health: A viewpoint from the state of the art

A laktózintoleranciáról: Múlt és jelen – II. rész

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