The Effect of a Heart Extract on the Coronary Blood Flow and Myocardial Oxygen Consumption in Dogs

Luethy, E; Rj, Bing

doi:10.1159/000167783

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1966

1968

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“…It is unlikely, therefore, that the reported clinical effects of the extract could he related to its sympathomimetic or histamine-like activity, and the question of whether Recosen possesses pharmacologic properties to explain its reported clinical efficacy remains unanswered. These results, however, may explain the cardiovascular effects reported in animal experiments when large doses were administered (12,13,17,19).…”

Section: Discussionmentioning

confidence: 95%

“…It has been reported lo produce positive inotropic effects in failed cat papillary muscle (12), lo increase coronary blood flow in the perfused, isolated dog and guinea pig heart (17,19), and lo increase coronary blood flow and left ventricular work in the intact dog (13). Conway (4) reported that Recosen decreased contractile force in the isolated cal, guinea pig, and rabbit heart, and produced a systemic vasodepres sor reaction in the spinal cat.…”

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confidence: 99%

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