The effect of a high-protein, low glycemic–load diet versus a conventional, high glycemic–load diet on biochemical parameters associated with acne vulgaris: A randomized, investigator-masked, controlled trial

Smith, Robyn; Mann, Neil; Braue, Anna; Mäkeläinen, Henna; Varigos, George

doi:10.1016/j.jaad.2007.01.046

Cited by 241 publications

(183 citation statements)

References 52 publications

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“…Similar results were reported by the study of Colidan et al where the authors reported the absence of acne among Papua New Guinea and Paraguay population due to their low glucose index diet (5,20). Similar results were found in a big randomized control study (20) where the authors reported the positive effect of low glucose load diet on decreasing acne lesion numbers, raising insulin sensitivity and decreasing weight (19,21). The results of the current studies coincide with the previous study, where the results showed significant association between acne and consuming carbohydrate.…”

Section: Discussion:-supporting

confidence: 90%

Relationship Between Diet and Acne Among Residents of Al-Madinah Al-Munwarah, Saudi Arabia.

Alsharif¹,

Albahlool²,

Kharabah³

et al. 2017

IJAR

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Section: Discussion:-supporting

confidence: 90%

Relationship Between Diet and Acne Among Residents of Al-Madinah Al-Munwarah, Saudi Arabia.

Alsharif¹,

Albahlool²,

Kharabah³

et al. 2017

IJAR

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“…30 Recent work has demonstrated the association of acne with the ingestion of a high glycemic load diet, with improvement occurring on a change to a higher protein, lower glycemic load diet. 4 The mechanism suggested for this relationship is through the induction of increased amounts of testosterone by elevated insulin and IGF-I levels secondary to dietary influences. This reinforces the likelihood that synergism of several influences impacting on increased levels of acnegenic androgens is at the root of acnegenesis.…”

Section: Discussionmentioning

confidence: 99%

“…3 Acne results from androgen-stimulated hyperkeratinization and obstruction of the pilosebaceous follicles secondary to failure of normal desquamation of the follicular epithelium; androgen-stimulated sebum production; subsequent colonization of the follicles by Propionibacterium acnes and Malassezia species; and, variably, inflammation. 4 Previous studies have shown an association between dietary intake of milk and prevalence of teenaged acne. Ecological studies suggest an association between Western diet and acne 5 whereas Robinson 6 reported that among 1925 patients who kept a food diary, the majority implicated milk in acne flares.…”

mentioning

confidence: 99%

Milk consumption and acne in teenaged boys

Adebamowo

Spiegelman

Berkey

et al. 2008

Journal of the American Academy of Dermatology

230

180

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Objective-We sought to examine the association between dietary dairy intake and teenaged acne among boys.Methods-This was a prospective cohort study. We studied 4273 boys, members of a prospective cohort study of youths and of lifestyle factors, who reported dietary intake on up to 3 food frequency questionnaires from 1996 to 1998 and teenaged acne in 1999. We computed multivariate prevalence ratios and 95% confidence intervals for acne.Results-After adjusting for age at baseline, height, and energy intake, the multivariate prevalence ratios (95% confidence interval; P value for test of trend) for acne comparing highest (>2 servings/d) with lowest (<1/wk) intake categories in 1996 were 1.16 (1.01, 1.34; 0.77) for total milk, 1.10 (0.94, 1.28; 0.83) for whole/2% milk, 1.17 (0.99, 1.39; 0.08) for low-fat (1%) milk, and 1.19 (1.01, 1.40; 0.02) for skim milk.Limitations-Not all members of the cohort responded to the questionnaire. Acne assessment was by self-report and boys whose symptoms might have been part of an underlying disorder were not excluded. We did not adjust for steroid use and other lifestyle factors that may affect occurrence of acne.Conclusion-We found a positive association between intake of skim milk and acne. This finding suggests that skim milk contains hormonal constituents, or factors that influence endogenous hormones, in sufficient quantities to have biological effects in consumers. Reprints not available from the authors. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptAcne remains a substantial cause of morbidity and occasional mortality among adolescents and young adults. 1 It is a common, chronic, and self-limiting skin disease that causes physical and psychologic morbidity in up to 90% of adolescents and young adults. 2 In Western countries, it affects all ages, but its maximum prevalence peaks at 16 to 18 years when 75% to 98% of this age group is affected. 2 Even though acne is more common in girls, overall and below the age of 12 years, after 15 years of age it is slightly more common in boys. 3 Acne results from androgen-stimulated hyperkeratinization and obstruction of the pilosebaceous follicles secondary to failure of normal desquamation of the follicular epithelium; androgen-stimulated sebum production; subsequent colonization of the follicles by Propionibacterium acnes and Malassezia species ; and, variably, inflammation. 4 Previous studies have shown an association between dietary intake of milk and prevalence of teenaged acne. Ecological studies suggest an association between Western diet and acne 5 whereas Robinson 6 reported that among 1925 patients who kept a food diary, the majority implicated milk in acne flares. In a previous study of US female nurses who reported their high-school diet and prevalence of physician-diagnosed severe teenaged acne, we found a positive association with intake of total and skim milk. 7 We also found a positive association between milk consumption and prevalence of acne among a prospective co...

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“…187 Acne is proposed to be an IGF-1-mediated disease, aggravated by diets high in milk protein and glycaemic index. [187][188][189] IGF1R primarily regulates cellular proliferation and to a lesser extend differentiation, whereas FGFR2b is predominantly involved in the regulation of cellular differentiation. 119,190 Comedogenesis is considered to be a process of increased keratinocyte proliferation as well as exaggerated keratinocyte differentiation (hyperkeratinisation).…”

Section: Interleukin-1α Network In Keratinocytesmentioning

confidence: 99%

Role of FGFR2-signaling in the pathogenesis of acne

Melnik

2009

Dermato-Endocrinology

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It is the purpose of this review to extend our understanding of the fibroblast growth factor (FGF) receptor-2b-signaling network in the pathogenesis of acne. A new concept of the role of FGFR2b-signaling in dermal-epithelial interaction for skin appendage formation, pilosebaceous follicle homeostasis, comedogenesis, sebaceous gland proliferation and lipogenesis is presented. The FGFR2-gain-of-function mutations in Apert syndrome and unilateral acneiform nevus are most helpful model diseases pointing the way to androgen-dependent dermalepithelial FGFR2-signaling in acne. Androgen-mediated upregulation of FGFR2b-signaling in acne-prone skin appears to be involved in the pathogenesis of acne vulgaris. In organotypic skin cultures, keratinocyte-derived interleukin-1α stimulated fibroblasts to secrete FGF7 which stimulated FGFR2b-mediated keratinocyte proliferation. Postnatal deletion of FGFR2b in mice resulted in severe sebaceous gland atrophy. The importance of FGFR2b in sebaceous gland physiology is further supported by the mode of action of anti-acne agents which have been proposed to attenuate FGFR2b-signaling. Downregulation of FGFR2b-signaling by isotretinoin explains its therapeutic effect in acne. Downregulation of FGFR2b-signaling during the first trimester of pregnancy disturbs branched morphogenesis and explains retinoid embryotoxicity. Insulin-like growth factor-1 (IGF-1), the mediator of growth hormone during puberty, intracts with androgen-dependent FGFR2b-signaling and links androgen-and FGF-mediated signal transduction important in sebaceous gland homeostasis. The search for a follicular defect in the dermalepithelial regulation of growth factor-signaling in acne-prone skin appears to be a most promising approach to clarify the pathogenesis of acne.

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The effect of a high-protein, low glycemic–load diet versus a conventional, high glycemic–load diet on biochemical parameters associated with acne vulgaris: A randomized, investigator-masked, controlled trial

Cited by 241 publications

References 52 publications

Relationship Between Diet and Acne Among Residents of Al-Madinah Al-Munwarah, Saudi Arabia.

Relationship Between Diet and Acne Among Residents of Al-Madinah Al-Munwarah, Saudi Arabia.

Milk consumption and acne in teenaged boys

Role of FGFR2-signaling in the pathogenesis of acne

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