The effect of a meniscal prosthesis on knee biomechanics and cartilage

Sommerlath, Karola; Gillquist, Jan

doi:10.1097/00042752-199207000-00023

Cited by 20 publications

(25 citation statements)

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“…Experimental studies concerning synthetic devices made of polyurethane, 36,37 polytetrafluoroethylene, 38 and polyester carbon 39 as possible alternatives to meniscus allografts have yielded unsatisfactory results in terms of biocompatibility, material properties, and chondroprotection. In a dog model, the resorbable bovine collagen scaffold developed by Stone et al 40 for regeneration of meniscal tissue showed host tissue ingrowth and formation of fibrocartilage resembling a normal canine meniscus after 9 and 12 months.…”

Section: Discussionmentioning

confidence: 99%

Tissue Engineering for Total Meniscal Substitution: Animal Study in Sheep Model

Kon

Chiari

Marcacci

et al. 2008

Tissue Engineering Part A

113

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Objective: The aim of the study was to investigate the use of a novel hyaluronic acid/polycaprolactone material for meniscal tissue engineering and to evaluate the tissue regeneration after the augmentation of the implant with expanded autologous chondrocytes. Two different surgical implantation techniques in a sheep model were evaluated. Methods: Twenty-four skeletally mature sheep were treated with total medial meniscus replacements, while two meniscectomies served as empty controls. The animals were divided into two groups: cell-free scaffold and scaffold seeded with autologous chondrocytes. Two different surgical techniques were compared: in 12 animals, the implant was sutured to the capsule and to the meniscal ligament; in the other 12 animals, also a transtibial fixation of the horns was used. The animals were euthanized after 4 months. The specimens were assessed by gross inspection and histology.

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Section: Discussionmentioning

confidence: 99%

Tissue Engineering for Total Meniscal Substitution: Animal Study in Sheep Model

Kon

Chiari

Marcacci

et al. 2008

Tissue Engineering Part A

113

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“…However, replacing the meniscus with just one horn attached or with neither horn attached leads to significant decreases in joint contact areas and increases in peak contact pressures [1,18,50,59,71]. Furthermore, in rabbits, transection of the anterior or posterior insertional ligaments of the meniscus has been shown to lead to osteochondral changes after 6 and 12 weeks, similar to meniscectomy [74].…”

Section: Insertional Ligamentsmentioning

confidence: 99%

Biomechanics of the meniscus-meniscal ligament construct of the knee

Masouros

McDermott

Amis

et al. 2008

Knee Surg Sports Traumatol Arthr

150

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The menisci of the knee act primarily to redistribute contact force across the tibio-femoral articulation. This meniscal function is achieved through a combination of the material, geometry and attachments of the menisci. The main ligaments that attach the menisci to the tibia (insertional ligaments, deep medial collateral ligament), the femur (meniscofemoral ligaments, deep medial collateral ligament) and each other (the anterior intermeniscal ligament) are the means by which the contact force between tibia and femur is distributed into hoop stresses in the menisci to reduce contact pressure at the joint. This means that the functional biomechanics of the menisci cannot be considered in isolation and should be considered as the functional biomechanics of the meniscus-meniscal ligament construct. This article presents the current knowledge on the anatomy and functional biomechanics of the meniscus and its associated ligaments. Much is known about the function of the meniscus-meniscal ligament construct; however, there still remain significant gaps in the literature in terms of the properties of the anterior intermeniscal ligament and its function, the properties of the insertional ligaments, and the most appropriate ways to reconstruct meniscal function surgically.

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“…Meniscectomy has been studied in animal models, where the mechanical, biochemical, structural, and metabolic changes in articular cartilage have been found to be similar to human osteoarthritis [28,45,49,50,54]. An increased understanding of the degenerative changes that occur following meniscectomy has led to efforts to improve the restoration of meniscal function through repair or reconstruction of the meniscus using allografts [1,6,9,11,21,31,42,43], autografts [30], or prosthetic materials [29,62,64,65,67]. Long-term information on the clinical outcome of meniscal allograft transplantation is presently limited, although patient satisfaction has been reported to be generally high (for recent reviews see [16,17,22,32,59,66]).…”

Section: Introductionmentioning

confidence: 99%

Joint degeneration following meniscal allograft transplantation in a canine model: mechanical properties and semiquantitative histology of articular cartilage

Elliott

Jones

Setton

et al. 2001

Knee surg. sports traumatol. arthrosc.

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This study examined the hypothesis that meniscal allograft transplantation serves a "chondroprotective" role and prevents the histological and biomechanical changes of the articular cartilage following meniscectomy. Skeletally mature mongrel dogs underwent total medial meniscectomy and received either a fresh meniscal allograft ( n=10) or no further treatment ( n=10). Semiquantitative histology and biomechanical analysis of the femoral articular cartilage was used to assess cartilage pathology 12 weeks following surgery. Histological analysis showed significant changes in cartilage structure that did not differ between the meniscectomy and allograft transplantation groups. Similarly, the tensile modulus of the surface zone cartilage was significantly lower than that in unoperated controls following either meniscectomy or allograft transplantation. A significant correlation was observed between the biomechanical and histological changes, suggesting that degenerative changes in cartilage structure and mechanical function are interrelated. Our findings do not support the hypothesis that meniscal allograft transplantation provides chondroprotection of the femoral condyle and also suggest that it does not lead to increased degenerative changes.

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The effect of a meniscal prosthesis on knee biomechanics and cartilage

Cited by 20 publications

References 0 publications

Tissue Engineering for Total Meniscal Substitution: Animal Study in Sheep Model

Tissue Engineering for Total Meniscal Substitution: Animal Study in Sheep Model

Biomechanics of the meniscus-meniscal ligament construct of the knee

Joint degeneration following meniscal allograft transplantation in a canine model: mechanical properties and semiquantitative histology of articular cartilage

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