The Effect of a New Benzodiazepine on the Polygraphically Monitored Sleep of Normal Volunteers

Abstract

All-night sleep was polygraphically monitored from ten normal volunteers who took placebo and three dosage levels of a new benzodiazepine hypnotic, SCH 16134, in a double-blind, crossover design. All dosages of the drug decreased the time to fall asleep, and the two highest dosages also decreased interspersed wakefulness. REM sleep was suppressed, but slow-wave sleep was not affected in this experiment. The subjective quality of sleep was improved by the new hypnotic. One subject reported that he felt lethargic the day after the largest dose.

Trifluoroacetaldehyde: A useful industrial bulk material for the synthesis of trifluoromethylated amino compounds

“…a-Unsubstituted [3] and chiral a-substituted trifluoroethylamino compounds [4][5][6] have been extensively used in the design of new pharmaceuticals and agrochemicals (Fig. 1).…”

Effects of quazepam as a preoperative night hypnotic: comparison with brotizolam

“…Quazepam induced a sleep pattern on electroencephalograms and reduced the induction time to sleeping, without causing muscle relaxation, in contrast to diazepam [11]. Quazepam 50 mg inhibited rapid eye movement (REM) sleep, but REM sleep was not inhibited with 10 mg and 25 mg quazepam [12]. In addition, both stage 1 and slow-wave sleep (stages 3 and 4) were decreased by quazepam [13].…”