The effect of a new non-sedative H1-receptor antagonist (LN2974) on the itching and scratching of patients with atopic eczema

Savin, J.A.; Dow, R. J.; Harlow, Bryan J.; Massey, H. Todd; Yee, Kevin

doi:10.1111/j.1365-2230.1986.tb00515.x

Cited by 38 publications

(11 citation statements)

References 5 publications

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“…Placebocontrolled studies of the antipruritic effect of oral antihistamines have shown conflicting results in AD patients. Some show no better effect than a placebo (68)(69)(70)(71)(72), while others show some or clear antipruritic effects (73)(74)(75)(76)(77). Many antihistamines have, in addition to their HI-receptor antagonistic effect, other important effects such as inhibition of mediator release and chemotaxis (78).…”

Section: Optionalmentioning

confidence: 99%

Itch and Atopic Dermatitis: An Overview

Wahlgren

1999

The Journal of Dermatology

210

166

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Itching is the hallmark of atopic dermatitis, and a vicious itch-scratch circle is easily established. Itching and scratching are important factors in the maintenance of symptoms and can have a significant impact on the sufferer's quality of life. The pathophysiology of itch in atopic dermatitis is still not understood. Unlike in urticaria, histamine is not considered to be a major pruritogen in atopic dermatitis. In fact, the peripheral pruritogens and their cellular origin(s) still remain to be identified in this disease. Various treatments are used to relieve the skin inflammation, itching, and scratching in patients with atopic dermatitis, but no specific antipruritic therapy is available. However, several nonspecific therapies can effectively break the vicious itch-scratch circle. The use of topical corticosteroids and emollients and the elimination of individual trigger factors are still first-line measures.

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Section: Optionalmentioning

confidence: 99%

Itch and Atopic Dermatitis: An Overview

Wahlgren

1999

The Journal of Dermatology

210

166

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“…Systemic anti-allergy drugs such as antihistamines are commonly recommended despite the fact that their use is controversial. This is because the clinical relevance of either sedative or non-sedative antihistamines is yet to be conclusively demonstrated in AD patients [1, 4, 6, 7, 8, 9, 10, 11]. It is still widely believed that the central sedative effect of earlier-generation sedative antihistamines (e.g.…”

Section: Introductionmentioning

confidence: 99%

Chlorpheniramine Is No More Effective than Placebo in Relieving the Symptoms of Childhood Atopic Dermatitis with a Nocturnal Itching and Scratching Component

Munday

Bloomfield²,

Goldman

et al. 2002

Dermatology

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Background: Childhood atopic dermatitis (AD) is a common disorder affecting 15% of children aged over 18 months. AD is associated with intense nocturnal itching. The central sedative effect of antihistamines is thought to be useful in interrupting the itching cycle and may prevent exacerbations. Objective: A multi-centred, double-blind, placebo-controlled study was carried out in 155 children to evaluate chlorpheniramine in alleviating symptoms of AD. Methods: Assessments were carried out over a 4-week study period consisting of 3 visits to out-patient clinics. During the visits the severity of AD and itching was rated using a series of visual analogue scale (VAS) and 5-point rating scales. Results: The use of chlorpheniramine resulted in no greater alleviation of AD symptoms than placebo. Conclusions: The findings contradict conventional wisdom that the sedative effect of earlier-generation antihistamines alleviates symptoms of AD. The study also indicates that the use of antihistamines in AD does not affect the amounts of topical treatment used over the short term.

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“…The efficacy of antihistamines has been studied in 26 RCTs (12 RCTs in Japan and 14 RCTs in abroad). Of these, 19 RCTs reported positive results, while the results of 6 RCTs were negative, and 1 RCT reported the efficacy observed in some patients (52%).…”

Section: Cq7 Is the Use Of Antihistamines Recommended For The Treatmmentioning

confidence: 99%

Clinical practice guidelines for the management of atopic dermatitis 2018

Katoh

Ohya

Ikeda

et al. 2019

The Journal of Dermatology

103

243

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Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion. The current strategies to treat AD in Japan from the perspective of evidence‐based medicine consist of three primary measures: (i) the use of topical corticosteroids and tacrolimus ointment as the main treatment for the inflammation; (ii) topical application of emollients to treat the cutaneous barrier dysfunction; and (iii) avoidance of apparent exacerbating factors, psychological counseling and advice about daily life. The guidelines present recommendations to review clinical research articles, evaluate the balance between the advantages and disadvantages of medical activities, and optimize medical activity‐related patient outcomes with respect to several important points requiring decision‐making in clinical practice.

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The effect of a new non-sedative H1-receptor antagonist (LN2974) on the itching and scratching of patients with atopic eczema

Cited by 38 publications

References 5 publications

Itch and Atopic Dermatitis: An Overview

Itch and Atopic Dermatitis: An Overview

Chlorpheniramine Is No More Effective than Placebo in Relieving the Symptoms of Childhood Atopic Dermatitis with a Nocturnal Itching and Scratching Component

Clinical practice guidelines for the management of atopic dermatitis 2018

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