2003
DOI: 10.1111/j.1471-0528.2003.02408.x
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The effect of a novel vaginal ring delivering oestradiol acetate on climacteric symptoms in postmenopausal women

Abstract: The collaborators are listed on page 758Objective Evaluate the efficacy and acceptability of a novel vaginal ring delivering oestradiol acetate (Menoring) versus oral oestradiol for relief of climacteric symptoms in postmenopausal women. Design Prospective, multicentre, randomised, double-blind, comparator-controlled, parallel group study.Setting Twenty-one centres in the United Kingdom.Population Postmenopausal women, aged <65 years experiencing 20 hot flushes/night sweats per week for two consecutive weeks. … Show more

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Cited by 29 publications
(4 citation statements)
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References 29 publications
(42 reference statements)
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“…On the other hand, administration by vaginal ring was similar in terms of drug delivery to the estradiol-releasing transdermal patch, and vaginal delivery has been effective in preventing climacteric symptoms in post-menopausal women [103,104]. In the light of the large variability of serum estradiol profiles within and between all the subjects [105,106], widely varying results render it difficult to compare the various treatment alternatives and the doses needed.…”
Section: Hormone Replacement Therapymentioning
confidence: 96%
“…On the other hand, administration by vaginal ring was similar in terms of drug delivery to the estradiol-releasing transdermal patch, and vaginal delivery has been effective in preventing climacteric symptoms in post-menopausal women [103,104]. In the light of the large variability of serum estradiol profiles within and between all the subjects [105,106], widely varying results render it difficult to compare the various treatment alternatives and the doses needed.…”
Section: Hormone Replacement Therapymentioning
confidence: 96%
“…Vaginal rings have been evaluated to treat either VMS or vaginal symptoms associated with menopause (ie, vulvovaginal atrophy) 7-33 . The release rates in these studies varied considerably and depended on the indication.…”
Section: Discussionmentioning
confidence: 99%
“…Today, there are many different delivery systems capable of achieving therapeutic estradiol concentrations. Currently marketed forms include oral [18], implants [19], vaginal ring [20], and transdermal patches [21], gels [22], sprays [23] and lotions [1].…”
Section: Transdermal Estrogen Therapiesmentioning
confidence: 99%