The effect of a single dose of escitalopram on sensorimotor networks

Weisstanner, Christian; Kägi, Georg; Krammer, Werner; Eap, Chin B.; Wiest, Roland; Missimer, John; Weder, Bruno

doi:10.1002/brb3.975

Cited by 5 publications

(6 citation statements)

References 57 publications

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“…Investigations in two fMRI studies of finger movements analogous to those underlying tactile exploration but without cognitive load revealed two patterns of cerebral activation during elementary tactile manipulation: a dominant pattern of motor control involving the primary motor and sensory cortex (SM1) as well as the premotor cortex, and a subdominant pattern reflecting less voluntary control [11]. In a recent study of healthy elderly subjects manipulating cuboids, we replicated these findings while imposing a dynamic grasp frequency of 1 Hz, consistent with the frequencies of sensory guided actions in humans [14].…”

Section: Introductionsupporting

confidence: 65%

Sensing form - finger gaiting as key to tactile object exploration: A data glove analysis of a prototypical daily task

Krammer

Missimer

Habegger

et al. 2020

Preprint

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Background Motor hand skill with associated dexterity is an important facility in meeting the challenges of daily activity and an important resource post-stroke. In this context, the present study investigated the finger movements of right-handed subjects during tactile manipulation of a cuboid, a prototypical component of tactile exploration. Methods For both hands of 22 subjects, we acquired the time series of consecutive multifinger cuboid manipulations using a digital data glove consisting of 29 sensors. Of these, 16 recorded the bending of metacarpo-phalangeal (MCP) and proximal interphalangeal (PIP) joints of the fingers, MCP and interphalangeal IP joints of the thumb, palm arch and carpo-metacarpal (CMC) joint of the thumb, and abduction between fingers. Results Using principle component analysis we decomposed the short action into motor patterns related to successive manipulations of the cuboid. The fraction of variance described by the principal components indicated that three components described the salient features of the single motor acts for each hand. Striking in the finger patterns was the prominent and varying roles of the MCP and PIP joints of the fingers, and the CMC joint of the thumb. An important aspect of the three components was their representation of distinct finger configurations within the same motor act. Principal component and graph theory analysis confirmed modular, functionally synchronous action of the involved joints. The computation of finger trajectories in one subject illustrated the workspace of the task, which differed for the right and left hands. Conclusion The study substantiates finger gaiting, described until now only in artificial systems, as the principal mechanism underlying this prototypical task, which is ubiquitous in daily object shape recognition.

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Section: Introductionsupporting

confidence: 65%

Sensing form - finger gaiting as key to tactile object exploration: A data glove analysis of a prototypical daily task

Krammer

Missimer

Habegger

et al. 2020

Preprint

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“…Performance of spatially motivated dexterity tasks has also been shown to correlate with decreased functional brain responses following chronic administration of paroxetine 13 , while our previous work shows that 1-week of escitalopram intake reduces premotor cortex response during sequential motor learning, despite comparable behavioural performance to a placebo group 14 . Preliminary evidence for a network-level modulation effect of SSRIs has also been reported with a single dose of escitalopram altering connectivity between sensorimotor regions during a pilot study of older adults performing a simple finger movement task 15 . Task-independent fMRI studies have also supported a connectome-wide effect of SSRIs.…”

Section: Introductionmentioning

confidence: 84%

Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake

Molloy

Zsido

Piecha

et al. 2021

Sci Rep

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Evidence suggests that selective serotonin reuptake inhibitors (SSRIs) reorganize neural networks via a transient window of neuroplasticity. While previous findings support an effect of SSRIs on intrinsic functional connectivity, little is known regarding the influence of SSRI-administration on connectivity during sequence motor learning. To investigate this, we administered 20 mg escitalopram or placebo for 1-week to 60 healthy female participants undergoing concurrent functional magnetic resonance imaging and sequence motor training in a double-blind randomized controlled design. We assessed task-modulated functional connectivity with a psycho-physiological interaction (PPI) analysis in the thalamus, putamen, cerebellum, dorsal premotor, primary motor, supplementary motor, and dorsolateral prefrontal cortices. Comparing an implicit sequence learning condition to a control learning condition, we observed decreased connectivity between the thalamus and bilateral motor regions after 7 days of escitalopram intake. Additionally, we observed a negative correlation between plasma escitalopram levels and PPI connectivity changes, with higher escitalopram levels being associated with greater thalamo-cortico decreases. Our results suggest that escitalopram enhances network-level processing efficiency during sequence motor learning, despite no changes in behaviour. Future studies in more diverse samples, however, with quantitative imaging of neurochemical markers of excitation and inhibition, are necessary to further assess neural responses to escitalopram.

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“…Our results suggest a causal link also exists between activation of macrophage/microglial cells and the white matter damage that leads to motor dysfunction. Indeed, citalopram and its active s‐isomer escitalopram can alter motor output (Weisstanner et al, 2018) and manual dexterity in chronic stroke patients after a single dose (Zittel et al, 2008), suggesting sensorimotor network level effects beyond direct protection of the neurovascular unit (Espinera et al, 2013). The functional benefits of citalopram appear related not to neuroprotection but neurorepair through alterations in cortical motor mapping that occur in the weeks after stroke (Pinto et al, 2017; Schneider et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Delayed citalopram administration reduces brain inflammation and enhances skilled motor function after ischaemic stroke in ‘MacGreen’ mice

Chen

McGregor

2022

Eur J of Neuroscience

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Recent evidence suggests that treatment with antidepressants may promote functional recovery. However, the timeframe in which these pharmacological agents can influence stroke recovery is not well understood. This research investigated whether delayed administration of citalopram, used clinically in the management of post-stroke depression, could improve long-term functional recovery following experimental stroke. MacGreen mice carrying an enhanced green fluorescent protein reporter gene in monocyte and macrophage populations were subjected to 45 min occlusion of the middle cerebral artery. Animals were administered citalopram (10 mg/kg/day, n = 20) or saline (n = 20) starting 3 days after stroke for 28 days. Neurological deficits and skilled motor performance in the staircase task were recorded for 9 weeks post stroke. Grey and white matter structural lesions were quantified at Week 9, and enhanced green fluorescent protein immunohistochemistry was used to evaluate the effect of citalopram on inflammation. Twenty-five animals were included in the final analysis. Citalopram-treated animals (n = 13) showed a significant increase in impaired forepaw use in the staircase task compared with saline-treated animals (n = 12) 2, 3 and 7 weeks post stroke but no difference in neurological score at any time point examined. Citalopram treatment was associated with decreased monocyte/macrophage cell density and increased white matter tract integrity within the ipsilateral cortex. In conclusion, delayed administration of citalopram decreased brain inflammation and produced functional gains in our mouse model of stroke. Beneficial effects on skilled motor functions were long-lasting.

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The effect of a single dose of escitalopram on sensorimotor networks

Cited by 5 publications

References 57 publications

Sensing form - finger gaiting as key to tactile object exploration: A data glove analysis of a prototypical daily task

Sensing form - finger gaiting as key to tactile object exploration: A data glove analysis of a prototypical daily task

Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake

Delayed citalopram administration reduces brain inflammation and enhances skilled motor function after ischaemic stroke in ‘MacGreen’ mice

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