The effect of a single oxytocin or carbetocin treatment on uterine contractility in early postpartum dairy cows

Bajcsy, Árpád Csaba; Szenci, O.; Weijden, G.C. van der; Doornenbal, Arie; Maassen, Francesca; Bartyik, J.; Taverne, M.A.M.

doi:10.1016/j.theriogenology.2005.05.040

Cited by 32 publications

(38 citation statements)

References 17 publications

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“…A drug without side effects and a long half-life stimulating a prolonged tocolytic effect might improve uterine clearance. The 4 use of carbetocin, a long acting analogue of oxytocin, has been investigated as a beneficial form of treatment on uterine involution in bovines [9], as well as in humans for the treatment of postpartum haemorrhage [10,11,12]. In adult, non-lactating anoestrous mares carbetocin has been shown to have a half-life of approximately 17 min., which is 2.5-fold longer than that of oxytocin, and not associated with any side effects [7].…”

Section: Introductionmentioning

confidence: 99%

Ex vivo influence of carbetocin on equine myometrial muscles and comparison with oxytocin

et al. 2012

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In order to determine the inter-cyclic effect of oxytocin and carbetocin on equine myometrial tissue, the effect of the drugs was evaluated through pharmacokinetic and pharmaco-dynamic studies. The complete pharmacokinetic profile for oxytocin was unknown and had to be established. To do so, 25 IU of oxytocin were administered intravenously to six cycling mares and blood samples were collected before and 2, 4, 8, 2 and 15 min after administration. The half-life of oxytocin was determined to be 5.89 min, the clearance rate 11.67 l/min, MRT 7.78 min, T max 2 min, and C max 0.51 ng/ml. The effective plasma concentration was estimated to be 0.25 ng/ml. This was similar to the concentration achieved for the organ bath study where the EC 50 was calculated at 0.45 ng/ml. To determine the inter-cyclic effect of oxytocin and carbetocin uterine myometrial samples were collected from slaughtered mares in oestrus, dioestrus and anoestrus. The samples were mounted in organ baths and exposed to four ascending, cumulative doses of oxytocin and carbetocin. Area under the curve and amplitude, E max and EC 50 were studied for each agonist and statistically evaluated. The effect of oxytocin on equine myometrial tissue was higher during dioestrus, and surprisingly anoestrus, than during oestrus, whereas the effect of carbetocin was the same independent of the stage of oestrous cycle. A significant difference was found for oestrous and anoestrous samples when oxytocin was used but not when carbetocin was used.

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Section: Introductionmentioning

confidence: 99%

Ex vivo influence of carbetocin on equine myometrial muscles and comparison with oxytocin

et al. 2012

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“…It is evident that contractions of the pregnant uterus are involved in the dilatation of the cervix during parturition [6,11] and that equally strong and even more frequent uterine contractions are present immediately after delivery of the calf [12][13][14][15][16][17][18][19][20][21]. After uncomplicated calvings, the frequency of these contractions decreases to almost zero within 2 days [13,20].…”

Section: Introductionmentioning

confidence: 99%

Cervical diameter in relation to uterine and cervical EMG activity in early postpartum dairy cows with retained placentas after PGF2alpha induced calving

et al. 2007

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The cervix must regain its normal diameter after parturition. Until now, little has been known about the pattern of cervical closure and the possible influences of myometrial and cervical contractions in this process. We continuously measured the cervical diameter with ultrasound cervimetry during the first 48 h after calving in six cows with retained fetal membranes, while uterine (n = 6) and cervical outer muscular layer (n = 4) electromyographic (EMG) activity was measured with bipolar EMG electrodes.We found that the cervical diameter which was 6.2 cm (AE0.7) at 1.4 h after calving, initially increased to 9.0 cm (AE1.0) during the first 14.8 h (AE2.8) postpartum. After this time, the diameter decreased gradually to 5.3 cm (AE1.0) at 48 h after calving. The overall EMG activity after parturition decreased by 59% (AE6) and 35% (AE17) for the uterus and cervix, respectively. The decrease in EMG activity was due to a 50% (AE7) decrease in EMG amplitudes of the myometrium; the EMG amplitudes of the cervix decreased by only 8% (AE21) (P > 0.05). At the same time in the cervix, burst frequency decreased by 69% (AE17), while the decrease in burst frequency of the myometrium was only 11% (AE5) (P > 0.05).Uterine myometrial and cervical EMG activity after parturition showed burst patterns. These contractions of the uterus and cervix were accompanied by and correlated with transient dilatations of the caudal cervix. This could have functional relevance in the evacuation of the uterus. #

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“…Understanding the interaction between prophylactic treatments in the postpartum uterus is essential for developing effective therapeutic strategies. One of the motivations for injecting oxytocin during the postpartum period is its uterotonic effect [19,40,41]. Our study showed that oxytocin had no significant effect on the serum concentration of CTC in early postpartum dromedary camels.…”

Section: Discussionmentioning

confidence: 62%

Effect of oxytocin and PGF2α on chlortetracycline absorption from the uterus of early postpartum camels (Camelus dromedarius)

et al. 2015

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The effect of a single oxytocin or carbetocin treatment on uterine contractility in early postpartum dairy cows

Cited by 32 publications

References 17 publications

Ex vivo influence of carbetocin on equine myometrial muscles and comparison with oxytocin

Ex vivo influence of carbetocin on equine myometrial muscles and comparison with oxytocin

Cervical diameter in relation to uterine and cervical EMG activity in early postpartum dairy cows with retained placentas after PGF2alpha induced calving

Effect of oxytocin and PGF2α on chlortetracycline absorption from the uterus of early postpartum camels (Camelus dromedarius)

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