The Effect of a Sleep High–Train Low Regimen on the Finger Cold-Induced Vasodilation Response

Amon, Mojca; Keramidas, Michail E.; Kounalakis, Stylianos N.; Mekjavic, Igor B.

doi:10.1089/ham.2011.1044

Cited by 12 publications

(18 citation statements)

References 37 publications

(39 reference statements)

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“…Whilst the data regarding the effects of acute altitude exposure of CIVD responses are equivocal, responses can be improved following long-term exposure. Participants acclimatised to 5100-7000 m for 45 days had a stronger CIVD response than subjects who had only spent 3 days exposed to an altitude of 5100 m (Daanen and van Ruiten 2000) and similar responses have been observed after 21 (Felicijan et al 2008) and 28 (Amon et al 2012) days of hypoxia. Recently, Keramidas et al (2018) investigated the effects of cold and hypoxia on central and local adaptations to the cold during an 11-day man-hauling expedition on the South Polar Plateau and observed that peripheral blood flow adaptations can occur but the main adaptation appears to be a suppression of shivering thermogenesis.…”

Section: Introductionsupporting

confidence: 64%

Single-digit cold-induced vasodilation adaptations during an Antarctic expedition

et al. 2020

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An increasing number of people are spending time in Polar Regions for work and tourism and this can increase the risk of tissue injuries, e.g. frostbite. The risk would be reduced if beneficial peripheral blood flow adaptions occurred but data regarding the trainability of the cold-induced vasodilation (CIVD) response are equivocal. Five healthy males spent almost 8 months in Antarctica; five of them at a semi-permanent camp (− 44 °C; 2752 m). CIVD tests (30 min index finger immersion into 0 °C water) were performed on the 12th, 39-40th, 67-68th, 179th and 234th days of the expedition in a climate-controlled caboose. Heart rate (HR), thermal sensation of the finger, pain sensation, and mean arterial pressure (MAP) were recorded. Minimum, maximum, and mean finger temperature were greater, onset time was earlier (r = 0.34), and amplitude was greater (r = 0.55) on day 234 than day 12 suggesting that adaptation occurred. Time-point data suggested that the adaptations were progressive. Cardiovascular and perceptual data also showed some adaptation. MAP was lower on day 234 than day 12 (r = 0.47 and r = 0.47) but mean HR was higher (r = 0.55). Mean and peak thermal sensation (r = 0.31-0.59; r = 0.31) and perceived pain (r = 0.58; r = 0.36) both improved over the course of the expedition. Of interest to Polar Region visitors, beneficial peripheral and perceptual adaptations to prolonged Antarctic exposure can occur with 2 h of daily outdoor exposure although the rates at which adaptation occurs differ.

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Section: Introductionsupporting

confidence: 64%

Single-digit cold-induced vasodilation adaptations during an Antarctic expedition

et al. 2020

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“…In both groups, a hypoxia-specific adaptation was indicated, given that after the confinement period, their hand vasomotor reactions were, in relative terms, better in the HYPO than the AIR trials. Amon et al (2012) observed enhanced finger CIVD response in both testing conditions following a 28-day sleep-high train-low regimen. Whether the present specific adaptation was due to the continuous mode of hypoxic stimulus or to the shorter duration of the exposure remains to be settled.…”

Section: Discussionmentioning

confidence: 76%

“…Amon et al. () observed enhanced finger CIVD response in both testing conditions following a 28‐day sleep‐high train‐low regimen. Whether the present specific adaptation was due to the continuous mode of hypoxic stimulus or to the shorter duration of the exposure remains to be settled.…”

Section: Discussionmentioning

confidence: 96%

“…Exposure to high altitude is commonly considered a predisposing environmental factor for local cold injury (Harirchi et al, 2005). Yet, the findings derived from crosssectional studies examining the peripheral vasomotor responses to local cooling, assumed to reflect risk of local cold injury, during and after prolonged hypoxia are equivocal; a few studies have observed an enhancement of local cold tolerance (Nair et al, 1973;Mathew et al, 1977;Rai et al, 1978;Felicijan et al, 2008;Amon et al, 2012), while others have reported either an impairment (Nair et al, 1973;Savourey et al, 1997;Purkayastha et al, 1999;Castellani et al, 2002) or no change (Nair et al, 1973;Mathew et al, 1977;Daanen & van Ruiten, 2000).…”

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confidence: 99%

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Hand temperature responses to local cooling after a 10‐day confinement to normobaric hypoxia with and without exercise

Keramidas

Kölegård

Mekjavic

et al. 2014

Scandinavian Med Sci Sports

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The study examined the effects of a 10-day normobaric hypoxic confinement (FiO2: 0.14), with [hypoxic exercise training (HT); n = 8)] or without [hypoxic ambulatory (HA; n = 6)] exercise, on the hand temperature responses during and after local cold stress. Before and after the confinement, subjects immersed their right hand for 30 min in 8 °C water [cold water immersion (CWI)], followed by a 15-min spontaneous rewarming (RW), while breathing either room air (AIR), or a hypoxic gas mixture (HYPO). The hand temperature responses were monitored with thermocouples and infrared thermography. The confinement did not influence the hand temperature responses of the HA group during the AIR and HYPO CWI and the HYPO RW phases; but it impaired the AIR RW response (-1.3 °C; P = 0.05). After the confinement, the hand temperature responses were unaltered in the HT group throughout the AIR trial. However, the average hand temperature was increased during the HYPO CWI (+0.5 °C; P ≤ 0.05) and RW (+2.4 °C; P ≤ 0.001) phases. Accordingly, present findings suggest that prolonged exposure to normobaric hypoxia per se does not alter the hand temperature responses to local cooling; yet, it impairs the normoxic RW response. Conversely, the combined stimuli of continuous hypoxia and exercise enhance the finger cold-induced vasodilatation and hand RW responses, specifically, under hypoxic conditions.

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“…Although the CIVD constitutes a complex physiological response and the impact of each parameter cannot be determined separately, the data of acclimatization/ habituation studies (Cheung and Daanen, 2012) suggest that, in terms of its cryoprotective function (Daanen and van der Struijs, 2005;Mathew et al, 1974), it is the increased perfusion-induced elevation in Tavg that constitutes the most decisive parameter during local cooling (cf. Amon et al, 2012;Keramidas et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Acute Effects of Normobaric Hypoxia on Hand-Temperature Responses During and After Local Cold Stress

Keramidas

Kölegård

Mekjavic

et al. 2014

High Altitude Medicine & Biology

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Keramidas, Michail E, Roger Kölegård, Igor B. Mekjavic, and Ola Eiken. Acute effects of normobaric hypoxia on hand-temperature responses during and after local cold stress. High Alt Med Biol. 15:183-191, 2014.-The purpose was to investigate acute effects of normobaric hypoxia on hand-temperature responses during and after a cold-water hand immersion test. Fifteen males performed two right-hand immersion tests in 8°C water, during which they were inspiring either room air (Fio 2 : 0.21; AIR), or a hypoxic gas mixture (Fio 2 : 0.14; HYPO). The tests were conducted in a counterbalanced order and separated by a 1-hour interval. Throughout the 30-min cold-water immersion (CWI) and the 15-min spontaneous rewarming (RW) phases, finger-skin temperatures were measured continuously with thermocouple probes; infrared thermography was also employed during the RW phase to map all segments of the hand. During the CWI phase, the average skin temperature (Tavg) of the fingers did not differ between the conditions (AIR: 10.2 -0.5°C, HYPO: 10.0 -0.5°C; p = 0.67). However, Tavg was lower in the HYPO than the AIR RW phase (AIR: 24.5 -3.4°C; HYPO: 22.0 -3.8°C; p = 0.002); a response that was alike in all regions of the immersed hand. Accordingly, present findings suggest that acute exposure to normobaric hypoxia does not aggravate the cold-induced drop in hand temperature of normothermic males. Still, hypoxia markedly impairs the rewarming responses of the hand.

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The Effect of a Sleep High–Train Low Regimen on the Finger Cold-Induced Vasodilation Response

Cited by 12 publications

References 37 publications

Single-digit cold-induced vasodilation adaptations during an Antarctic expedition

Single-digit cold-induced vasodilation adaptations during an Antarctic expedition

Hand temperature responses to local cooling after a 10‐day confinement to normobaric hypoxia with and without exercise

Acute Effects of Normobaric Hypoxia on Hand-Temperature Responses During and After Local Cold Stress

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