Information technology used in the health sector is known as e-health. Smartphone applications are starting to be widely used for long-term condition monitoring management in the medical and health fields. Perioperative cardiac surgery procedures require long-term monitoring. This study aimed to find out about smartphone use in peri-operative cardiac surgery. A systematic review design. The reporting framework uses Featured Reporting Items for Systematic Review and Followed Metaanalysis to report findings. Data Sources, CINAHL, ProQuest, Science Direct, and Google Scholar searched for English-language articles published from January 2010 to August 2020 with the keywords"cardiac surgery," "smartphone," and "peri-operative". Six articles that met the inclusion criteria were the samples analyzed in this study. The instrument used to assess the quality of the study uses the Downs and Black checklist. In the pre-operation stage, a smartphone application has been used for surgical planning, assessment, education, training, diagnosis, telemedicine, navigation, and behavior modification interventions. In the intraoperative stage, smartphones are used for hemodynamic monitoring. In the postoperative stage, smartphones are used for monitoring surgical wounds. The benefits of smartphones in peri-operative cardiac surgery include diagnosis, telemedicine, navigation, and surgical planning, training, data collection, hemodynamic monitoring, nursing intervention media, and surgical wounds.