Background: Patient education is a key factor in promoting the health of people with acute coronary syndrome. Families are crucial to implement educational programs. Therefore, this research aimed at determining the family-centered interactive education efficacy using social networks on the lifestyle of patients with acute coronary syndrome (ACS). Materials andMethods: The present clinical trial was conducted on 96 cases with ACS, who were randomly assigned to control and intervention groups. The former only was provided with routine training before discharge, while the latter, in addition to routine training before discharge, received education on social networking and sending text/visual messages. At baseline and three months after the intervention, the Walker’s Lifestyle Questionnaire was completed. The paired t-test was employed for data analysis.Results: the average lifestyle value of the intervention group was significantly higher compared with the control group after the intervention (P˂0.001). Moreover, the lifestyle score was significantly different pre- and post- intervention in the intervention group (P˂0.001). Conclusion: Interactive education using social networks is useful to promote the lifestyle in cases with ACS, which seems effective in planning the follow-up for these patients.