The Effect of ABO Blood Group on von Willebrand Response to Exercise

Ribeiro, Jerri Luiz; Salton, Gabriele D.; Bandinelli, Eliane; Oliveira, Álvaro Reischak de; Roisenberg, Israel

doi:10.1177/1076029607305530

Cited by 9 publications

(4 citation statements)

References 9 publications

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“…From our study, two results indicate the active involvement of the endothelium in the hemostatic improvement following exercise in haemophilia A: the acute increase, though not statistically significant, in plasma VWF and the elevation of endothelial cellderived microparticles. The elevated VWF levels are in agreement with recent reports in dogs [24] as well as in humans postexercise [25][26][27]. Elevated plasma levels of cytokines such as TNFa and IL-6 and enhanced tissue factor activity have been reported following exercise signifying a possible role for the endothelium in the pro-hemostatic response following exercise [28].…”

Section: Discussionsupporting

confidence: 90%

Thromboelastography reflects global hemostatic variation among severe haemophilia A dogs at rest and following acute exercise

et al. 2009

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The heterogeneity among severe haemophilia A patients reflects on variable tendencies for bleeding and also variable responses to FVIII therapy. This variability cannot be detected or predicted by routine coagulation tests. Thromboelastography (TEG) has recently been evaluated for assessing hemostatic patterns in haemophiliacs and proved valuable in monitoring therapy and/or prophylaxis, however, usually only in limited small case series. Exercise is an important component of overall haemophilia care, however, in severe haemophiliacs there is an increased risk of bleeding. The availability of a validated hemostatic test to evaluate the influence of exercise would be advantageous. This study has used TEG analysis to evaluate the global hemostatic status of a group of severe haemophilia A dogs at rest and after a standardized period of exercise. The study demonstrated significant inter and intra-individual variations based on TEG patterns at rest and following acute exercise as well as significant improvement of global hemostasis after exercise in the majority of tested dogs. The study supports the utilization of TEG in assessment of the hemostatic pattern in severe haemophilia A and provides a potential for utilizing TEG evaluation in managing exercise regimens for haemophilia care.

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Section: Discussionsupporting

confidence: 90%

Thromboelastography reflects global hemostatic variation among severe haemophilia A dogs at rest and following acute exercise

et al. 2009

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“…Furthermore, blood group non-O has been associated with an increased risk of CHD [48]–[50]. Ribeiro et al observed that males with blood group non-O (N = 8) had higher post-exercise VWF:Ag levels than males with blood group O (N = 8), although the rise of VWF:Ag was not statistically significantly different between the groups [51]. In our study, subjects with blood group non-O had higher levels at exhaustion (median [IQR], 1.60 IU/mL [1.2–2.0]), than subjects with blood group O (1.29 IU/mL [1.1–1.6], p = 0.03).…”

Section: Discussionmentioning

confidence: 99%

Performance Related Factors Are the Main Determinants of the von Willebrand Factor Response to Exhaustive Physical Exercise

et al. 2014

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BackgroundPhysical stress triggers the endothelium to release von Willebrand Factor (VWF) from the Weibel Palade bodies. Since VWF is a risk factor for arterial thrombosis, it is of great interest to discover determinants of VWF response to physical stress. We aimed to determine the main mediators of the VWF increase by exhaustive physical exercise.Methods105 healthy individuals (18–35 years) were included in this study. Each participant performed an incremental exhaustive exercise test on a cycle ergometer. Respiratory gas exchange measurements were obtained while cardiac function was continuously monitored. Blood was collected at baseline and directly after exhaustion. VWF antigen (VWF:Ag) levels, VWF collagen binding (VWF:CB) levels, ADAMTS13 activity and common variations in Syntaxin Binding Protein-5 (STXBP5, rs1039084 and rs9399599), Syntaxin-2 (STX2, rs7978987) and VWF (promoter, rs7965413) were determined.ResultsThe median VWF:Ag level at baseline was 0.94 IU/mL [IQR 0.8–1.1] and increased with 47% [IQR 25–73] after exhaustive exercise to a median maximum VWF:Ag of 1.38 IU/mL [IQR 1.1–1.8] (p<0.0001). VWF:CB levels and ADAMTS13 activity both also increased after exhaustive exercise (median increase 43% and 12%, both p<0.0001). The strongest determinants of the VWF:Ag level increase are performance related (p<0.0001). We observed a gender difference in VWF:Ag response to exercise (females 1.2 IU/mL; males 1.7 IU/mL, p = 0.001), which was associated by a difference in performance. Genetic variations in STXBP5, STX2 and the VWF promoter were not associated with VWF:Ag levels at baseline nor with the VWF:Ag increase.ConclusionsVWF:Ag levels strongly increase upon exhaustive exercise and this increase is strongly determined by physical fitness level and the intensity of the exercise, while there is no clear effect of genetic variation in STXBP5, STX2 and the VWF promoter.

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“…One study of 1,117 blood donors revealed that blood group O had the lowest average concentration of circulating von Willebrand antigen (vWF:Ag, 75%), blood group AB had the highest concentration (123%), and intermediate concentrations were observed in group A (106%) and group B (117%). 7 The higher vWF:Ag concentrations in individuals with blood group AB are likely related to individuals with blood group A or blood group B being homozygous or heterozygous for the alleles encoding the A-and B-transferases. In this context, individuals with the AO or BO genotype have higher vW-F:Ag concentrations than individuals with the OO genotype, but lower concentrations than individuals with the AA, BB, or AB genotype, which all confer similar high concentrations of vWF:Ag.…”

Section: Hansen Et Almentioning

confidence: 99%

“…The relationship between ABO blood group and bleeding may be related to correlations between ABO blood group and plasma concentrations of von Willebrand factor (vWF) and factor VIII. One study of 1,117 blood donors revealed that blood group O had the lowest average concentration of circulating von Willebrand antigen (vWF:Ag, 75%), blood group AB had the highest concentration (123%), and intermediate concentrations were observed in group A (106%) and group B (117%) 7 . The higher vWF:Ag concentrations in individuals with blood group AB are likely related to individuals with blood group A or blood group B being homozygous or heterozygous for the alleles encoding the A‐ and B‐transferases.…”

Section: Introductionmentioning

confidence: 99%

ABO blood group is related to bleeding in cardiac surgery

Hansen

Sprogøe

Möller

et al. 2020

Acta Anaesthesiol Scand

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Background Increased bleeding and blood product transfusions during cardiac surgery are associated with poor outcomes. The patient's ABO blood group is related to hemostatic balance, although it is unclear whether this influences bleeding during cardiac surgery. This study aimed to evaluate whether ABO blood group is related to bleeding during cardiac surgery. Methods This retrospective study evaluated data from 17,058 cardiac surgical procedures that were performed in four Danish cardiosurgical centers. Data regarding chest tube drainage and transfusion volumes were retrieved from a clinical database and combined with information regarding ABO group. The primary outcome was chest tube drainage volume and the secondary outcomes were transfused volumes of various blood products. Results Blood group O had the largest chest tube drainage volume (mean: 745 mL, 95% CI: 720‐771 mL) and blood group AB had the smallest volume (mean: 664 mL, 95% CI: 598‐731 mL). The inter‐group difference in the mean drainage volume was 81 mL (95% CI: 8‐154 mL, P < .05). Patients with blood group A or blood group B had mean drainage volumes that were between the volumes for groups AB and O. Relative to group O, group AB received smaller mean volumes of all blood products. The most pronounced difference was in platelet concentrates, with mean values of 170 mL for group O (95% CI: 157‐184 mL) and 63 mL for group AB (95% CI: 34‐92 mL). Conclusion The patient's ABO group appears to be related to volumes of chest tube drainage and transfused blood products during cardiac surgery.

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The Effect of ABO Blood Group on von Willebrand Response to Exercise

Cited by 9 publications

References 9 publications

Thromboelastography reflects global hemostatic variation among severe haemophilia A dogs at rest and following acute exercise

Thromboelastography reflects global hemostatic variation among severe haemophilia A dogs at rest and following acute exercise

Performance Related Factors Are the Main Determinants of the von Willebrand Factor Response to Exhaustive Physical Exercise

ABO blood group is related to bleeding in cardiac surgery

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