The Effect of ACP₁-ADA₁Genetic Interaction on Human Life Span

Abstract

Acid phosphatase (ACP 1 ) is a polymorphic enzyme which catalyzes the conversion of flavinmononucleotide (FMN) to riboflavin and regulates the cellular concentration of flavin-adeninedinucleotide (FAD) and, consequently, energy metabolism. Its activity is modulated by adenosine deaminase (ADA 1 ) genotype. Aim of our work is to verify whether individuals with a high proportion of ACP 1 f isozyme and carrying ADA*2 allele, displaying the highest phosphatase activity, may have a higher life expectancy.Genomic DNA was extracted from peripheral blood of 569 females and 509 males (18-106 years) randomly recruited from Central Italy. These samples were subdivided into three sex- Pre-print version. Visit