The Effect of Acupressure on the Severity of Pruritus and Laboratory Parameters in Patients Undergoing Hemodialysis: A Randomized Clinical Trial

Karjalian, Fatemeh; Momennasab, Marzieh; Yoosefinejad, Amin Kordi; Jahromi, Shahrokh Ezzatzadegan

doi:10.1016/j.jams.2020.05.002

Cited by 15 publications

(18 citation statements)

References 25 publications

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“…Indeed, in patients undergoing hemodialysis, AA had a beneficial effect on conditions such as sleep disorders, depression, pruritus, and xerostomia (63). Karjalian a treatment for UP (7), and PMS scores improved after AA in studies conducted by Mai et al and He et al (39,44).…”

Section: Discussionmentioning

confidence: 99%

“…The benefit of acupuncture may be due to increased levels of anti-inflammatory cytokines, resulting from an altered type 1 to type 2 T-helper cell balance (6). Moreover, stimulation of Quchi (LI11) significantly reduced pruritus in patients with UP (7).…”

Section: Introductionmentioning

confidence: 99%

“…For ATT, local acupoint infrared (AIR) radiation can improve nerve sensitivity and promote peripheral blood circulation, which may help patients with UP ( 9 ). Transdermal therapeutic administration of Chinese medicines at acupoints has also ameliorated pruritus ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

“…Increased the number of the mast cells is one etiology for UP ( 7 ). Mast cells degranulation could release inflammatory markers such as histamine, tumor necrosis factors, and IL-6 ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

“…Mast cells degranulation could release inflammatory markers such as histamine, tumor necrosis factors, and IL-6 ( 10 ). The activation of acupressure at LI11 can destroy mast cell which releasing inflammatory markers that might be the one etiology for UP and improve pruritus ( 7 ). Electroacupuncture (EA) at ST36 suppressing the activation of mast cells, leading to decrease of nerve growth factor (NGF) and tropomyosin receptor kinase A (TrkA) proteins ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of acupoint stimulation as a treatment for uremic pruritus: A systematic review and meta-analysis

Chung

Chuo

et al. 2022

Front. Med.

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BackgroundUremic pruritus causes sleep disturbances, poor quality of life, and increased morbidity in patients with chronic kidney disease. Acupuncture has been shown to improve uremic pruritus. There is limited evidence of the efficacy of traditional Chinese therapies. We conducted a systematic review and meta-analysis to evaluate the efficacy of acupoint stimulation therapy in patients with uremic pruritus.MethodsA systematic search of seven databases (up to Sep 2022) was conducted for randomized controlled trials that evaluated the clinical efficacy of acupuncture, acupressure, auricular acupressure, acupoint injection, acupoint thermal therapy, acupoint sticking therapy, or transcutaneous electrical acupoint stimulation in the treatment of patients with uremic pruritus. Two reviewers selected eligible articles for inclusion in the meta-analysis and evaluated the risk of bias via Cochrane Collaboration. The results of pruritus assessments and uremic pruritus-related laboratory parameters were analyzed.ResultsForty trials published between 2002 and 2022, including a total of 2,735 participants, were identified for inclusion in the meta-analysis. The effective rates for acupuncture, auricular acupressure, and the combination of acupoint injection and acupoint massage were significantly greater in patients with uremic pruritus compared to the control group. The levels of serum BUN, PTH, and histamine levels were significantly lower vs. control group.ConclusionsAcupuncture, auricular acupressure, and the combination of acupoint injection and acupoint massage seem to be effective in improving uremic pruritus in patients with chronic kidney disease. However, further investigation of these potential treatments is now warranted in larger patient populations and over a longer time frame.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022354585, identifier: PROSPERO CRD42022354585.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%