The effect of acute and chronic lithium on forskolin-induced reduction of rat activity

Abstract

Forskolin is a diterpene derivative that activates adenylate cyclase and raises cAMP levels in the cell. Both i.p. and i.c.v. forskolin cause behavioral hypoactivity. Lithium has been reported for many years to block cAMP accumulation, but the behavioral relevance of this biochemical effect is not clear. We studied the effect of acute and chronic lithium on icv forskolin-induced hypoactivity. Acute lithium had no effect, but chronic lithium significantly blocked forskolin-induced hypoactivity. The effect of chronic lithium occurred with both forskolin in DMSO and with a water-soluble forskolin derivative. These results suggest that this behavioral model can be used to investigate whether new inhibitors of adenylate cyclase possess lithium-like effects.

Chaperone heat shock protein 70 in nucleus accumbens core: a novel biological target of behavioural sensitization to morphine in rats

“…KNK 437 and GGA were dissolved in DMSO. No obvious adverse effect in rats was observed with stereotaxic injection of DMSO, which is consistent with other studies (Bersudsky et al, 1997;Chen et al, 2001;Xu et al, 2009). MB was dissolved in 0.9% saline.…”

Psychotropic drugs affect Ser9-phosphorylated GSK-3β protein levels in rodent frontal cortex

“…After decapitation brains were removed, frontal cortex specimens dissected and frozen at x80 xC until processed. The drug doses administrated were based upon previous studies in which it has been shown that these regimes result in rodent blood levels within the therapeutic range in patients (Bersudsky et al, 1997;Jardemark et al, 2000;Shaldubina et al, 2002;Shapiro et al, 2000). Haloperidol was from Janssen-Cilag (Raritan, NJ, USA), clozapine from Novartis (Basel, Switzerland) and LiCl and valproate were from Sigma (St. Louis, MO, USA).…”

Ανάπτυξη Ενός Μοντέλου Για Τη Μελέτη Της Διπολικής Διαταραχής Και Της Δράσης Των Σταθεροποιητικών Της Διάθεσης Στον Επίμυ

“…Σν ιίζην ξπζκίδεη θαη ηα επίπεδα ηνπ θπθιηθνχ ΑΜΡ ζην ΚΝ, κεηψλνληάο ηα (Böer et al, 2008˙ Marmol, 2008˙ Montezinho et al, 2007˙ Wilting et al, 2007˙ Wang et al, 1999˙ Mori et al, 1996 ελψ πξφζθαηα εξεπλεηηθά δεδνκέλα ππνδεηθλχνπλ φηη ην θπθιηθφ ΑΜΡ ξπζκίδεηαη θαη απφ ηε δξαζηηθφηεηα ηεο GSK-3β, ε νπνία αλαζηέιιεηαη απφ ην ιίζην (Rao et al, 2010). Δπηπξνζζέησο, ε ρξφληα, αιιά φρη ε νμεία, ρνξήγεζε ιηζίνπ έρεη βξεζεί φηη αλαζηέιιεη ηελ επαγφκελε απφ θνξζθνιίλε 40 ππνδξαζηεξηφηεηα (Bersudsky et al, 1997 (Lee et al, 1999).…”