The Effect of Acute Hypovolemia on the Release of “Aldosterone” and on the Renal Excretion of Sodium1

Fine, Daniel H.; Meiselas, Leonard E.; Auerbach, Theresa

doi:10.1172/jci103602

Cited by 31 publications

(5 citation statements)

References 31 publications

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“…Aldosterone, a mineralocorticoid hormone released from the zona glomerulosa after activation of the renin-angiotensin system by decreased renal perfusion, may serve as a marker of decreased effective circulating volume during acute illness. 11,12 We hypothesized that the FACTT patients with higher initial BNP concentration and lower initial aldosterone concentration would experience lower 60-day mortality when randomized to the conservative strategy.…”

mentioning

confidence: 99%

B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS

Semler

Marney²,

Rice

et al. 2016

Chest

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confidence: 99%

B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS

Semler

Marney²,

Rice

et al. 2016

Chest

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“…Acute hemorrhage has been demonstrated to stimulate aldosterone output in dog and man (1)(2)(3). Because of the relatively greater increment in aldosterone than in glucocorticoid secretion or excretion, a specific aldosterone-stimulating effect has been postulated.…”

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confidence: 99%

The Effect of Hemorrhage Upon Aldosterone Secretion in Normal and Hypophysectomized Dogs*

Mulrow¹,

Ganong²

1961

J. Clin. Invest.

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Acute hemorrhage has been demonstrated to stimulate aldosterone output in dog and man (1-3). Because of the relatively greater increment in aldosterone than in glucocorticoid secretion or excretion, a specific aldosterone-stimulating effect has been postulated. All of these studies, however, were performed in subjects with intact pituitaries. In view of the accumulating evidence (4-8) of the role of ACTH in regulating secretion of aldosterone, especially in the acute experiment, the role of the pituitary in the increment in aldosterone secretion following hemorrhage remains uncertain. The present experiments were designed to compare the effect of acute hemorrhage on aldosterone secretion in normal and in hypophysectomized dogs. METHODSFifteen male mongrel dogs (9.5 to 15 kg) were studied. The normal group of 5 dogs had the right lumboadrenal vein cannulated by the technique of Hume and Nelson (9) on the day prior to the experiment. At the start of the experiment each dog was anesthetized with Nembutal and the right femoral vein and artery were cannulated, the latter for continuous blood pressure recording, using a Grass model 5 polygraph and a Statham strain gage. Ten-to 15-ml samples of adrenal vein blood were collected. Each sample was immediately replaced by dog bank blood to avoid the effects of intermittent small hemorrhages. After two to three control samples, collected at 20 to 30 minute intervals, 15 ml of blood per kg body weight was withdrawn from the femoral artery within 6 minutes. Collection of the first post-hemorrhage sample of adrenal vein blood was begun 10 minutes after the start of hemorrhage. An additional one or two samples were collected at 20-to 30-* This work has been supported by Grants C-3998 and A-3818 from the United States Public Health Service and a grant-in-aid from The Commonwealth Fund. This report was presented at the meeting of the Federated American Societies for Experimental Biology, Chicago, April, 1960. minute intervals. The shed blood was then transfused over 6 minutes and two to three post-transfusion samples were collected at intervals similar to those of the posthemorrhage period. Following this last sample, 1 IU of ACTH (Upjohn) was administered through the femoral vein and collection of adrenal vein blood was begun 10 minutes later.Ten dogs were hypophysectomized by the transbuccal route (10), and the right adrenal vein was cannulated on the experimental day. One hour after hypophysectomy, collection of adrenal vein samples was begun. The protocol thereafter was similar to that of the normal dogs. Blood samples were centrifuged immediately after collection, and the plasma was separated and frozen for subsequent analysis. Aldosterone and corticosterone were measured by the isotope derivative technique of Kliman and Peterson (11), and 17-dihydroxycorticoids by the Silber-Porter method (12). Secretion rates were calculated from the concentrations and the plasma flow per minute. Completeness of hypophysectomy was checked by gross examination of the hypothalamus and sella ...

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“…During these latter procedures, increase of PRC is associated with tachycardia, reduction of 'effective' blood volume, reduced central venous pressure and small variation of arterial blood pressure. Renal retention of sodium and water also results (Pearce & Newman, 1954;Goodkind, Ball & Davis, 1957;Fine, Meiselas & Auerbach, 1958;de Vries, Ten Holt, van Daatselaar, Mulder & Borst, 1960;Mills, Thomas & Williamson, 1962). It has been shown that increased activity of the sympathetic nervous system is involved in the release of renin after assumption of the upright posture (Gordon et al 1967), haemorrhage (Hodge et al 1966;Bunag et al 1966) and in acute sodium depletion by diuretics (Vander & Luciano, 1967).…”

Section: Renin Secretion In Sheep Discussionmentioning

confidence: 99%

Circulatory Changes and Renin Secretion in Sheep in Response to Feeding.

Blair‐West

1968

Aust J Exp Biol Med

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SUMMARY1. The effect of feeding on the circulation, on renin release and on renal function has been examined in the sheep.2. There was a rapid reduction of plasma volume within 15 min of starting to eat dry feed.3. This was accompanied by an abrupt rise in systolic blood pressure and by a more gradual and prolonged elevation of heart rate.4. Within 30 min of feeding there occurred renal conservation of sodium and water which continued for at least 2-3 hr. Renin was released into the circulation of sheep that ate rapidly;slow feeders did not show this response. 6. The rise in plasma renin concentration was inhibited by infusing a solution similar in composition to mixed saliva at a rate that prevented the change in plasma volume.7. It is concluded that the rapid transfer of sodium and water from the Circulation to the rumen via the saliva during ingestion of dry feed is sufficient to activate the renin/angiotensin system.

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The Effect of Acute Hypovolemia on the Release of “Aldosterone” and on the Renal Excretion of Sodium1

Cited by 31 publications

References 31 publications

B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS

B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS

The Effect of Hemorrhage Upon Aldosterone Secretion in Normal and Hypophysectomized Dogs*

Circulatory Changes and Renin Secretion in Sheep in Response to Feeding.

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