The effect of acute uræmia upon the survival of skin homografts. Histological changes in the regional lymph-nodes

Host‐tumor Antagonism. Xxxiii. Cancer Immunity—a Review and an Analysis of Some Factors in Host Resistance to Cancer*

“…Makari (99) believes that tumors contain a specific tumor polysaccharide substance (TPS). Chemical carcinogens, viruses, physical agents, hormones and other agents which are now regarded as causes of cancer share the ability to produce in most tissues a substance, TPS, which he believes results from an alteration of the normal polysaccharide substance which is known to surround all cells.…”

“…It was shown by Burwell and co‐workers (71) that the survival of skin homografts was prolonged when acute experimental uremia was induced in rabbits. The possible mechanisms for the delay in the primary immune response to skin homografts in uremic animals include: reduced antigen dosage, impaired uptake of antigen, lymphocytic lysis, and metabolic impairment of the antibody‐forming organs.…”

Host‐tumor Antagonism. Xxxiv. The Use of Progestational Agents to Retard Homograft Rejection in Rabbits; A Pilot Study*

“…The classical natural example of modification of the host's reaction is seen in patients with agammaglobulinemia; these patients accept homografts from donors who are unrelated to them in any way. Immunologic deficiencies of variable degree are also found in cases of uremia (3), lymphoma (especially Hodgkin's disease), advanced malignant lesions of other types (4, 5), cirrhosis of the liver (5), pyridoxine deficiency (6), and last but not least, pregnancy (7).…”