The effect of adding zirconium dioxide nanoparticle to acrylic denture base on porosity and candida albicans adhesion

Antony, Angeline; Dipoyono, Haryo Mustiko; Ismiyati, Titik

doi:10.22146/majkedgiind.63382

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Their mechanism involves the production of active oxygen species, which inhibit the normal budding process of pore formation in the cell wall. This causes the cell wall to disintegrate via ion outflow, which inhibits fungal growth by disturbing cell function [ 21 , 22 , 23 ]. A denture in the oral cavity is constantly subjected to thermal stresses.…”

Section: Discussionmentioning

confidence: 99%

“…A study by Antony et al indicated that using ZrO 2 NPs at concentrations of 2.5% and 5% reduced the porosity of the denture base surface and reduced the number of adherent C. albicans . Nevertheless, the same study concluded that 2.5% and 5% ZrO 2 NPs had a fungistatic effect [ 22 ]. Jangra et al found that ZrO 2 NPs mainly targeted Escherichia coli and Staphylococcus aureus bacterial strains and Aspergillus niger fungal strains.…”

Section: Introductionmentioning

confidence: 99%

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Antibiofilm Activity of 3D-Printed Nanocomposite Resin: Impact of ZrO2 Nanoparticles

et al. 2023

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Poly(methyl methacrylate) (PMMA) is a commonly used material, as it is biocompatible and relatively cheap. However, its mechanical properties and weak antibiofilm activity are major concerns. With the development of new technology, 3D-printed resins are emerging as replacements for PMMA. Few studies have investigated the antibiofilm activity of 3D-printed resins. Therefore, this study aimed to investigate the antibiofilm activity and surface roughness of a 3D-printed denture base resin modified with different concentrations of zirconium dioxide nanoparticles (ZrO2 NPs). A total of 60 resin disc specimens (15 × 2 mm) were fabricated and divided into six groups (n = 10). The groups comprised a heat-polymerized resin (PMMA) group, an unmodified 3D-printed resin (NextDent) group, and four 3D-printed resin groups that were modified with ZrO2 NPs at various concentrations (0.5 wt%, 1 wt%, 3 wt%, and 5 wt%). All specimens were polished using a conventional method and then placed in a thermocycler machine for 5000 cycles. Surface roughness (Ra, µm) was measured using a non-contact profilometer. The adhesion of Candida albicans (C. albicans) was measured using a fungal adhesion assay that consisted of a colony forming unit assay and a cell proliferation assay. The data were analyzed using Shapiro–Wilk and Kruskal–Wallis tests. A Mann–Whitney U test was used for pairwise comparison, and p-values of less than 0.05 were considered statistically significant. The lowest Ra value (0.88 ± 0.087 µm) was recorded for the PMMA group. In comparison to the PMMA group, the 3% ZrO2 NPs 3D-printed group showed a significant increase in Ra (p < 0.025). For the 3D-printed resins, significant differences were found between the groups with 0% vs. 3% ZrO2 NPs and 3% vs. 5% ZrO2 NPs (p < 0.025). The highest Ra value (0.96 ± 0.06 µm) was recorded for the 3% ZrO2 NPs group, and the lowest Ra values (0.91 ± 0.03 µm) were recorded for the 0.5% and 5% ZrO2 NPs groups. In terms of antifungal activity, the cell proliferation assay showed a significant decrease in the C. albicans count for the 0.5% ZrO2 NPs group when compared with PMMA and all other groups of 3D-printed resins. The group with the lowest concentration of ZrO2 NPs (0.5%) showed the lowest level of C. albicans adhesion of all the tested groups and showed the lowest Candida count (0.29 ± 0.03). The addition of ZrO2 NPs in low concentrations did not affect the surface roughness of the 3D-printed resins. These 3D-printed resins with low concentrations of nanocomposites could be used as possible materials for the prevention and treatment of denture stomatitis, due to their antibiofilm activities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibiofilm Activity of 3D-Printed Nanocomposite Resin: Impact of ZrO2 Nanoparticles

et al. 2023

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“…filler is used in research because it produces good dispersion and eliminates aggregation so that the metrics and fillers are more compatible [17]. Anthony, et al (2021) found that the best results were obtained at a concentration of 5% ZrO2 where the porosity at a concentration of 5% was smaller compared to a concentration of 2.5%, so it was concluded that the addition of more filler could reduce the porosity of the composite [18] this affects the strength of the denture teeth composite.…”

Section: Preparation Of Denture Teeth Compositementioning

confidence: 99%

Effect of Silanized Zirconium Oxide (ZrO<sub>2</sub>) Filler on Hardness of Acrylic-Based Denture Teeth

Ilma,

Ashary,

Asghar

et al. 2024

MSF

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PMMA is used in dentistry as the main matrix for denture manufacture. Dentures are a substitute for natural human teeth which must have mechanical properties and are biocompatible to withstand mastication in the oral cavity. However, PMMA has poor mechanical properties, so it is necessary to add filler to the PMMA matrix. In this study zirconium oxide (ZrO2) was used as a filler because it has good mechanical properties and aesthetics. The aim of this study was to study the effect of adding ZrO2 filler on the hardness and compatibility of denture composites at concentrations ( 0%, 1%, 3%, 5%, and 7%). The bulk composite polymerization method used in the manufacture of dental composites is by mixing powdered materials in the form of PMMA, BPO as an initiator, and ZrO2 filler which has been silanized with liquid materials in the form of MMA monomer and cross-linking agent Ethylene Glycol Dimethacrylate (EGDMA). Mixing powder liquid in this method uses hand mixing in a stainless steel container until it reaches the dough phase and is packed into a mold according to ASTM for Vickers hardness tests. Heat cured polymerization technique was used for the curing process in a water bath at 74°C for 90 minutes and continued at 100°C for 30 minutes. The results obtained in this study, the addition of ZrO2 filler to a concentration of 5% showed an increase in the hardness value up to 37.6 VHN. Keywords: Denture Teeth, Composite Bulk Polymerization, Heat cured Polymerization, Zirconium Oxide

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The effect of adding zirconium dioxide nanoparticle to acrylic denture base on porosity and candida albicans adhesion

Cited by 2 publications

References 8 publications

Antibiofilm Activity of 3D-Printed Nanocomposite Resin: Impact of ZrO2 Nanoparticles

Antibiofilm Activity of 3D-Printed Nanocomposite Resin: Impact of ZrO2 Nanoparticles

Effect of Silanized Zirconium Oxide (ZrO<sub>2</sub>) Filler on Hardness of Acrylic-Based Denture Teeth

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