The Effect of Adiponectin on the Regulation of Filaggrin Expression in Normal Human Epidermal Keratinocytes

Choi, Sun Young; Kim, Min Jeong; Ahn, Ga Ram; Park, Kui Young; Lee, Mi-Kyung; Seo, Seong Jun

doi:10.5021/ad.2018.30.6.645

Cited by 10 publications

(10 citation statements)

References 34 publications

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“…Kawai and colleagues demonstrated that adiponectin has a pro-apoptotic effect on keratinocytes [ 96 ]. Furthermore, through MAPK signaling, activator protein 1, and silent mating-type information regulation 2 homolog (SIRT1), adiponectin promotes the expression of filaggrin in keratinocytes, which is a key element in preserving skin barrier function [ 97 , 98 ].…”

Section: Adiponectinmentioning

confidence: 99%

The Role of Adipokines in the Pathogenesis of Psoriasis

Kiełbowski

Bakinowska

Ostrowski

et al. 2023

IJMS

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Psoriasis is a chronic and immune-mediated skin condition characterized by pro-inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes, and keratinocytes represent the main cell subtypes involved in the pathogenesis of psoriasis, while the interleukin-23 (IL-23)/IL-17 pathway enhances the disease progression. Human adipose tissue is an endocrine organ, which secretes multiple proteins, known as adipokines, such as adiponectin, leptin, visfatin, or resistin. Current evidence highlights the immunomodulatory roles of adipokines, which may contribute to the progression or suppression of psoriasis. A better understanding of the complexity of psoriasis pathophysiology linked with adipokines could result in developing novel diagnostic or therapeutic strategies. This review aims to present the pathogenesis of psoriasis and the roles of adipokines in this process.

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Section: Adiponectinmentioning

confidence: 99%

The Role of Adipokines in the Pathogenesis of Psoriasis

Kiełbowski

Bakinowska

Ostrowski

et al. 2023

IJMS

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“…In addition, AP-1 luciferase activity and phosphorylation of ERK and p38 were enhanced by Cs-ME. A previous study demonstrated that the expression of FLG is dependent on ERK-AP-1 signaling in normal human epidermal keratinocytes (NHEKs) [51]. e p38 MAPK pathway has been shown to be important for the induction of HAS-1 expression in human fibroblast-like synoviocytes [52,53].…”

Section: Discussionmentioning

confidence: 99%

“…Among the targets, expression of FLG and HAS-1, but not TGM-1, HAS-2, and HAS-3, was increased in Cs-ME (50 and 100 μg/ml)-treated HaCaT cells (Figure 4(a) ). As it has been reported that the expression of FLG and HAS-1 genes is regulated by the transcription factor AP-1 [33], we tested if Cs-ME alters AP-1 activity. Cs-ME dose-dependently upregulated AP-1 luciferase activity (Figure 4(b)).…”

Section: E Effect Of Cs-me On Skin Barrier Functionmentioning

confidence: 99%

Antioxidative and Skin Protective Effects of Canarium subulatum Methanol Extract on Keratinocytes

Hwang

Kim

Choi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Canarium subulatum is a traditional medical herb used in South Asia. Recently, the anti-inflammatory effects of C. subulatum methanol extract (Cs-ME) have been reported; however, the effect of Cs-ME on skin physiology has not yet been elucidated. Therefore, in this study, we evaluated the protective effect of Cs-ME on UV-induced skin aging and cell death as well as the reinforcing effect on the skin barrier. According to viable cell counting and MTT assays, Cs-ME significantly reduced UV-evoked HaCaT cell death. Cs-ME blocked reactive oxygen species (ROS) generation in UV-irradiated HaCaT cells and showed radical scavenging activity against DPPH and ABTS. In addition, H2O2-induced cell death was inhibited by Cs-ME, indicating that Cs-ME protects cells from UV-derived cell death through the suppression of ROS. PCR analysis revealed that Cs-ME diminished the expression of aging-related HYAL-1 and MMP-1 genes in UV-treated HaCaT cells. Elevated HYAL-1 and MMP-1 mRNA expression in H2O2-stimulated HaCaT cells was also decreased by Cs-ME, suggesting that Cs-ME exerts antiaging activity via the inhibition of ROS. Expression of skin barrier components including filaggrin and hyaluronic acid synthase-1 was increased by Cs-ME and was modulated by ERK/p38-AP-1 signaling. Collectively, our data show that Cs-ME has cytoprotective and antiaging activity based on antioxidant properties. Furthermore, Cs-ME exerts skin barrier protective ability by regulating the AP-1 signaling pathway. Therefore, Cs-ME has the potential for use as an ingredient in cosmetics to protect the skin from UV irradiation, prevent photoaging, and strengthen the skin barrier.

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“…The proFLG presented in stratum granulosum is degraded to generate FLG that is a critical role for the integrity of the SC and calcium is involved in the procession of proFLG degradation during terminal epidermal differentiation 21 . Finally, FLG is degraded to produce its partial component amino acids, a mixture of hygroscopic amino acids, called natural moisturizing factor that is contributed to SC acidification and hydration 22 . It has been founded that the skin presents the degressive expression of FLG in patients with AD 23 .…”

Section: Discussionmentioning

confidence: 99%

A Novel Effect of Lipids Extracted from Vernix Caseosa on Regulation of Filaggrin Expression in Human Epidermal Keratinocytes

Qiao

Jia

et al. 2019

Ann Dermatol

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Background: Vernix caseosa (VC), which is known as a unique human substance, is a biofilm that covers the skin of most human newborns. VC has many biological functions including anti-infective, skin cleansing and skin barrier repair. Objective: In the study, we purpose to investigate the novel effect of lipids extracted from VC on the regulation of filaggrin (FLG) expression and anti-inflammation in normal human epidermal keratinocyte (NHEK) cells. Methods: The lipids were extracted by chloroform/methanol (Folch method) and the major properties of fatty acid methyl esters were determined with gas chromatography-mass spectrometer. The relative viability of NHEK cells was evaluated by Cell Counting Kit 8 assay. The related expression of skin barrier protein was accessed with real-time quantitative polymerase chain reaction, Western blot and Immunofluorescence in NHEK cells with or without poly (I:C). Meanwhile, the changes of thymic stromal lymphopoietin (TSLP) and tumor necrosis factor alpha (TNF-α) are analyzed by enzyme-linked immunosorbent assay. Results: VC lipids mostly contained saturated and branched chains fatty acids. The expression of mRNA and protein of FLG were significantly increased after the supplement with lipid in NHEK cells. Meanwhile, lipids reversed the inhibition of poly (I:C) on FLG. Moreover, lipids suppressed the over secretion of TSLP and TNF-α induced by poly (I:C). Conclusion: These results indicate that lipids extracted from VC has positive effects on the expression of FLG and anti-inflammation, suggesting that lipids of VC may be used for a reference for novel therapeutic method in reducing and remedying skin disease like atopic disease. (Ann Dermatol 31(6) 611∼620, 2019

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The Effect of Adiponectin on the Regulation of Filaggrin Expression in Normal Human Epidermal Keratinocytes

Cited by 10 publications

References 34 publications

The Role of Adipokines in the Pathogenesis of Psoriasis

The Role of Adipokines in the Pathogenesis of Psoriasis

Antioxidative and Skin Protective Effects of Canarium subulatum Methanol Extract on Keratinocytes

A Novel Effect of Lipids Extracted from Vernix Caseosa on Regulation of Filaggrin Expression in Human Epidermal Keratinocytes

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