The effect of adjuvant oral application of honey in the management of postoperative pain after tonsillectomy in adults: A pilot study

Abstract

Objective To analyze the effect of adjuvant oral application of honey for treating postoperative pain after tonsillectomy. Design Single centre prospective cohort study. Setting Two cohorts of patients after tonsillectomy. Participants 56 patients treated with honey 8 times per day (honey group), 18 patients treated without honey (control group); baseline analgesia were non-steroidal anti-inflammatory drugs (NSAID) or coxibs; opioids were used as pro re nata (PRN) medication; mean age 34.4 ± 13.4 years; 36% women. Main outcome measures On first to fifth postoperative day, patients rated their pain using the validated questionnaire of the German-wide project Quality Improvement in Postoperative Pain Treatment (QUIPS) including a numeric rating scale (NRS, 0-10) for determination of patient's pain. QUIPS allows standardized assessment of patients' characteristics andpain-associated patientreported outcomes (PROs). The influence of preoperative and postoperative parameters on patients' postoperative pain were estimated by univariate and multivariate statistical analysis.

Demanding New Honey Qualitative Standard Based on Antibacterial Activity

“…20-36) exhibited a greater antibacterial effect compared to samples from supermarkets (Nos. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. The MIC values of about 50% of supermarket honey samples against S. aureus were identical to those of artificial honey, compared to 25% of honey samples from local food shops.…”

“…Honey, a traditional sweetener, is considered as a functional food, and several recent clinical studies have proved its health-beneficial properties such as improving lipid profile [ 1 ], reducing postoperative pain [ 2 ] and inflammation [ 3 ] and modulating of hypertension [ 4 ]. Besides its oral consumption, honey has successfully been used topically in the treatment of a broad spectrum of surgical and chronic wounds [ 5 , 6 ] and mucositis [ 7 ] as well as herpes simplex labialis [ 8 ].…”

“…2 , a major antibacterial compound in honey, was determined in 36 commercial honey samples (Figure2). The average H 2 O 2 content in supermarket and local food shop honey samples was 256 and 565 µM, respectively.…”

Potential Therapeutic Benefits of Honey in Neurological Disorders: The Role of Polyphenols

“…Its most common application is for healing wounds and skin infections [ 27 , 28 , 29 ]. Honey possesses significant antibacterial [ 30 , 31 , 32 ], antiviral [ 33 , 34 ], antifungal [ 27 , 35 , 36 , 37 ], antioxidant [ 27 , 38 , 39 , 40 ], anti-inflammatory [ 41 , 42 , 43 ], antineoplastic [ 28 , 44 ], antimicrobial [ 45 , 46 , 47 ], anticarcinogen [ 48 , 49 , 50 ], antiarrhythmic [ 51 , 52 ], antileishmanial [ 53 , 54 ], antithrombotic, antiplatelet [ 55 , 56 ], antimutagenic [ 57 , 58 ], antinociceptive [ 59 , 60 ], antimycobacterial [ 7 , 61 ], antiproliferative [ 62 , 63 ], and immune-boosting [ 64 , 65 , 66 ] properties. It is also shown to have hypocholesterolemic [ 67 , 68 ], cardioprotective [ 69 , 70 ], antihypertensive [ 71 ], hepatoprotective […”

Does photobiomodulation therapy improve the postoperative outcomes of tonsillectomy? A systematic review and meta-analysis

“…8 Although previous guidelines for managing pain shortly after tonsillectomy have been documented elsewhere, they differ from one another. 4,8,9 Combinations of non-steroidal antiinflammatory drugs and paracetamol prescribed preoperatively, intraoperatively, and postoperatively are strongly recommended unless there are absolute contraindications. 8 The use of codeine and opioids for the surgical management of pain is also an alternative, but prescription of these medications involves clinical challenges due to the concerns about side effects, including life-threatening respiratory depression.…”