The Effect of Adjuvant Radiotherapy on Mortality Differs According to Primary Tumor Location in Women with Node-Positive Breast Cancer

Vinh-Hung, Vincent; Truong, Pauline T.; Janni, Wolfgang; Nguyen, Nam P.; Vlastos, Georges; Royce, Melanie; Woodward, Wendy A.; Promish, Donald I.; Tai, Patricia; Soete, Guy; Balmer-Majno, S.; Cutuli, B.; Storme, Guy

doi:10.1007/s00066-009-1921-z

Cited by 12 publications

(12 citation statements)

References 61 publications

(69 reference statements)

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“…Tumour size, ER/PR status and ductal histology were also in keeping with the findings of other correlation studies [25,27]. We have previously reported the poorer prognosis associated with breast inner quadrant location [33]. The present study found a trend for a higher risk of PET-positive distant organs associated with medial/ central tumour location.…”

Section: Fig 2 Probabilities Of Nodal Involvement According To Pet Nsupporting

confidence: 92%

Diagnostic and prognostic correlates of preoperative FDG PET for breast cancer

Vinh-Hung

Everaert

Lamote

et al. 2012

Eur J Nucl Med Mol Imaging

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Purpose To explore the preoperative utility of FDG PET for the diagnosis and prognosis in a retrospective breast cancer case series. Methods In this retrospective study, 104 patients who had undergone a preoperative FDG PET scan for primary breast cancer at the UZ Brussel during the period 2002-2008 were identified. Selection criteria were: histological confirmation, FDG PET performed prior to therapy, and breast surgery integrated into the primary therapy plan. Patterns of increased metabolism were recorded according to the involved locations: breast, ipsilateral axillary region, internal mammary chain, or distant organs. The end-point for the survival analysis using Cox proportional hazards was disease-free survival.The contribution of prognostic factors was evaluated using the Akaike information criterion and the Nagelkerke index. Results PET positivity was associated with age, gender, tumour location, tumour size >2 cm, lymphovascular invasion, oestrogen and progesterone receptor status. Among 63 patients with a negative axillary PET status, 56 (88.9 %) had three or fewer involved nodes, whereas among 41 patients with a positive axillary PET status, 25 (61.0 %) had more than three positive nodes (P<0.0001). In the survival analysis of preoperative characteristics, PET axillary node positivity was the foremost statistically significant factor associated with decreased disease-free survival (hazard ratio 2.81, 95% CI 1.17-6.74). Conclusion Preoperative PET axillary node positivity identified patients with a higher burden of nodal involvement, Electronic supplementary material The online version of this article

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Section: Fig 2 Probabilities Of Nodal Involvement According To Pet Nsupporting

confidence: 92%

Diagnostic and prognostic correlates of preoperative FDG PET for breast cancer

Vinh-Hung

Everaert

Lamote

et al. 2012

Eur J Nucl Med Mol Imaging

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“…According to current guidelines, chest wall irradiation is indicated in patients with T3 or T4 tumors, node-positive disease, or in patients with marginal or incomplete resection [12,20]. The benefits of chest wall irradiation have been illustrated in many prospective trials and several metaanalyses [8,19,25,26]. It has, thus, been demonstrated that adjuvant radiotherapy reduces the risk of local relapse by approximately two-thirds ultimately improving long-term survival of the patients [7,19,23,2].…”

Section: Introductionmentioning

confidence: 99%

Fibrotic Changes after Postmastectomy Radiotherapy and Reconstructive Surgery in Breast Cancer

et al. 2010

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“…It conveyed, also to the nonradiation oncologist, the evidence supporting the multiple benefits of radiation treatment in terms of both local and locoregional tumor control and patient survival if radiotherapy is systematically included as an integral part of a multimodal treatment plan. Several recent studies have also found radiotherapy to have beneficial effects on the survival of breast cancer patients [15,25,26].…”

Section: Discussionmentioning

confidence: 99%

Optimizing the Quality of Breast Cancer Care at Certified German Breast Centers

et al. 2011

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The current data confirm proof-of-concept for the established benchmarking program, which allows participating institutions to be compared and changes in quality of BC care to be tracked over time. Overall, marked QI increases suggest that BC care in Germany improved from 2003-2009. Moreover, it has become possible for the first time to demonstrate improvements in the quality of BC care longitudinally for individual breast centers. In addition, subgroups of relevant QIs can be used to demonstrate the progress achieved, but also the need for further improvement, in specific interdisciplinary specialties.

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The Effect of Adjuvant Radiotherapy on Mortality Differs According to Primary Tumor Location in Women with Node-Positive Breast Cancer

Cited by 12 publications

References 61 publications

Diagnostic and prognostic correlates of preoperative FDG PET for breast cancer

Diagnostic and prognostic correlates of preoperative FDG PET for breast cancer

Fibrotic Changes after Postmastectomy Radiotherapy and Reconstructive Surgery in Breast Cancer

Optimizing the Quality of Breast Cancer Care at Certified German Breast Centers

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