The effect of administrating hyoscine bromide on pregnancy rate before embryo transfer in ART cycles

Abstract

Assisted reproductive technology methods i.e., IVF and ICSI were extensively used for treatment of infertility. Although, these methods have many advantages but ART pregnancy rate remains low (30%-35%). It seems that uterine peristalsis occurred after rhCG administration in turn resulting to impair implantation of the transferred embryos. Therefore this study was conducted to possess of whether hyoscine bromide can effectively alleviate uterine contraction and then have any effect on the reproductive outcome. Healthy women who underwent IVF or ICSI cycles (n = 142) were randomly assigned to one of two groups at the start of the cycle. Group control (n = 71) without applied hyoscine and group experiment (n = 71) applied hyoscine (25 mg). Controlled ovarian hyperstimulation was induced with follicle stimulating hormone (FSH). Sperm preparation and ovarian puncture for in vitro maturation and fertilization (IVF) of oocyte were carried out for 42 hours after rhCG injection. Two weeks after rhCG injection, bhCG pregnancy test to determine pregnancy outcome in both groups was done and the outcome results, along with other information were recorded separately. The pregnancy rate in experimental group was significantly higher than that of control group. when all of the cycles with or without giving 25 mg of hyosine were stratified by the mean total follicles (more/less than 2 follicles) and embryos (more/less than 25 kg/m 2), the Patients' age, the quality grade of embryos and infertility duration (more/less than 5 years), the reproductive outcome, in overall, in the subjects with more than 10 oocytes, 5 embryos, more than quality A and B grades of embryos, less than 35 years age and also less than 5 years infertility duration was more pronounced than the other patients. But the other parameter was not affected by the reproductive outcome. Clinical or statistical improvement of the reproductive outcome could be demonstrated in the hyosine treated group especially with increasing the mean total follicles, embryo, quality of embryo in women with low age and infertility duration. However, further well-designed studies are essential to offer a final conclusion.

Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis

“…A meta-analysis of two small placebo-controlled RCT (Sohrabvand et al, 2009;Zargar et al, 2013) also showed this positive effect on pregnancy rates: RR 1.82 (1.10-3.03), I 2 : 35% (Figure 7; low quality of evidence: Table 4). Beta-adrenergic receptor antagonists such as ritodrine and terbutaline are well known for reducing UC in the pregnant uterus (de Heus et al, 2008).…”

Association Between miR-605 A>G, miR-608 G>C, miR-631 I>D, miR-938 C>T, and miR-1302-3 C>T Polymorphisms and Risk of Recurrent Implantation Failure

“…However, despite the fact that assisted reproductive technology (ART) has experienced rapid developments over the past several years, pregnancy rates using these techniques remain relatively low. 1,2 Recurrent implantation failure (RIF) is one of the most common causes of pregnancy failure after receiving ART. 3 The RIF is diagnosed when clinical pregnancy failure occurs after 2 consecutive IVF-ETs to the endometrium using at least 4 high-quality embryos.…”

“…However, despite the fact that assisted reproductive technology (ART) has experienced rapid developments over the past several years, pregnancy rates using these techniques remain relatively low. 1,2…”

The effect of peri-implantation administration of uterine relaxing agents in assisted reproduction treatment cycles: a systematic review and meta-analysis

“…Three studies reported the findings of trials investigating the use of the nitric oxide donor in the form of nitroglycerin patch (Farzi et al, 2005;Ohl et al, 2002;Shaker et al, 1993) and two studies investigated the use of the antimuscarinic agent Hyoscine (Sohrabvand et al, 2009;Zargar et al, 2013).…”

“…Many randomized controlled trials (RCTs) have been conducted to evaluate the efficacy of these drugs when administered in the peri-implantation period of assisted reproduction technique cycles (Bernabeu et al, 2006;Dal Prato and Borini, 2009;Farzi et al, 2005;Firouzabadi et al, 2007;Hanevik et al, 2012;Moraloglu et al, 2010;Ng et al, 2014;Ohl et al, 2002;Pinheiro et al, 2003;Shaker et al, 1993;Tsirigotis et al, 2000;Zargar et al, 2013). The results of these trials, however, have been conflicting.…”