The effect of administration of amodiaquine on some Parameters of neurobehaviour of wistar rats

Abstract

Summary:The effect of administration of Amodiaquine (AQ) on some parameters of neurobehaviour of Wistar rats was carried out. Twenty adult Wistar rats weighing between 160-190g were divided equally into four groups. Group 1 served as the control, while groups 2, 3 and 4 were the experimental groups. The control group received distilled water. Groups 2 and 3 were treated with 8.75mg/kg and 17.50mg/kg respectively of AQ for three days, while group 4 was treated with 8.75mg/kg of AQ for six days. Neurobehaviour test using the open field was carried out twelve hours after the last administrations. There were no significant differences between the control and the experimental groups in total locomotor activity (TLA), central square duration (CSD), stretch-attend (SA) and defecation. In the central square frequency (CSF), group 3 was significantly (P<0.05) higher than all the groups, while the control was the same as group 4, but higher than group 2, with the difference not being significant. In conclusion, AQ increased TLA and exploration, while simultaneously reducing anxiety in Wistar rats and these were dose dependent.

Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo

“…These findings are in line with other studies even when repeated treatment has been given [3, 10, 35]. ASAQ was also found responsible of significantly higher events rate than other antimalarials in the literature [3, 29]. However, one recent study shows that AEs were no more numerous in ASAQ group than in AL one, even in cases of readministration [36].…”

“…Abnormal behavior was common although the literature reports behavioral changes as rare AEs of 4-aminoquinoline derivatives (including amodiaquine) and the summary of product characteristics (SmPC) does not mention it among psychiatric disorders [27, 28]. One study about effect of administration of amodiaquine on rats highlighted various behavioral disorders due to drug effects [29]. However, it is not excluded that these (subjective) effects were over-reported considering the fact of participating in a clinical trial was a new experience for both parents and child.…”

Amodiaquine‐induced reproductive toxicity in adult male rats

“…AQ is currently deemed a safe option for the treatment of malaria (Massaga et al, 2008;Otuechere et al, 2012;Saka et al, 2012b). Despite this classification, recent studies noted that AQ negatively affects multiple organs (Ajani et al, 2008;Ekong et al, 2008;Ajeigbe et al, 2012;Abolaji et al, 2014;Heidari et al, 2014). We found that AQ treatment disrupts spermatogenesis in a dose-dependent whereas 5 mg/kg (B), 10 mg/kg (C), and 15 mg/kg (D) AQ treatments induced a significant increase in the number of apoptotic germ cells.…”

“…The clinical use of AQ, however, is also associated with organ damage, including hepatotoxicity (Larrey et al, ). Closer investigation of AQ‐mediated effects in rats have demonstrated a dose‐dependent effect on behavior, including total locomotor activity, central square frequency, and anxiety (Ekong et al, ); increased gastric acid secretion and altered the gastrointestinal mucosal integrity (Ajeigbe et al, ); elevated levels of reactive oxygen species, lipid peroxidation, protein carbonylation, and mitochondrial depolarization (Heidari et al, ); hypotensive and bradycardic effects due to altered K + channels and extracellular Ca 2+ influx (Adaramoye and Almeida, ); as well as side effects on indices of cardiovascular disease, such as serum total cholesterol, high‐versus‐low density lipoprotein and cholesterol concentration, and atherogenic index (Ajani et al, ; Adebayo et al, ). Co‐administration of artesunate and AQ was also shown to alter markers of liver function and lipid peroxidation in female rats (Abolaji et al, ).…”