1964
DOI: 10.1042/bj0910307
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The effect of adrenalectomy on the metabolism of the mammary glands of lactating rats

Abstract: The mammary glands of lactating rats extensively utilize glucose as an energy source and as a source of metabolic precursors for the synthesis of milk constituents. It is well established that the pentose phosphate pathway ofglucose utilization is very active in milk-producing mammary-gland tissue

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Cited by 27 publications
(11 citation statements)
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“…If the results are considered on the basis of the activity of the total gland, it is clear that 3 days of involution decreases the conversion of [1 -14C]glucose into 14CO2 by about eightfold, whereas the conversion of [6-14C]glucose into 14CO2 is reduced by fourfold, relative to the values reported by Greenbaum & Darby (1964) for manmnary-gland tissue from normal rats that had been lactating for 8 days. It may be deduced that the activity of the pentose phosphate pathway for glucose degradation is considerably lowered by the involutionary process, relative to the activity of the Embden-Meyerhof pathway.…”
Section: Discussionmentioning
confidence: 77%
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“…If the results are considered on the basis of the activity of the total gland, it is clear that 3 days of involution decreases the conversion of [1 -14C]glucose into 14CO2 by about eightfold, whereas the conversion of [6-14C]glucose into 14CO2 is reduced by fourfold, relative to the values reported by Greenbaum & Darby (1964) for manmnary-gland tissue from normal rats that had been lactating for 8 days. It may be deduced that the activity of the pentose phosphate pathway for glucose degradation is considerably lowered by the involutionary process, relative to the activity of the Embden-Meyerhof pathway.…”
Section: Discussionmentioning
confidence: 77%
“…The incorporation of 14C from [1-14C]glucose, [6-14C]glucose and [1-14C]acetate into the total lipids of mammary-gland tissue from involuting glands is negligible when compared with the incorporation found for lactating tissue (Greenbaum & Darby, 1964), and reserpine does not affect this low rate of incorporation (Table 2). In the presence of phenazine methosulphate no incorporation of 14C could be detected.…”
Section: Resultsmentioning
confidence: 96%
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“…The depression in the pentose phosphate pathway flux indicated by tracer data may be due to both decreased activity of glucose-6-P dehydrogenase and decreased availability of NADP as suggested by Greenbarn and Darby (2). The provision of a hydrogen acceptor, phenmine methosulfate, increased the production of "CO, from 1-'%-glucose more in tissue from adrenaleetomized than nomal animals, but did not make them equal.…”
Section: [Nadpj/[nadpha] [Nadp]/[nadph$ [Nad]/[nadh] Calculated Frommentioning
confidence: 88%