1968
DOI: 10.1113/jphysiol.1968.sp008571
|View full text |Cite
|
Sign up to set email alerts
|

The effect of adrenaline on the tension developed in contractures and twitches of the ventricle of the frog

Abstract: SUMMARY1. The effect of adrenaline on contracture and twitch tension in frog's ventricle has been examined, using the superfused preparation.2. In 1 mM-Ca Ringer, contractures induced with excess KCl concentrations from 50 to 200 mm, are reduced by 1 x 106 g/ml. adrenaline to an average of 0*62 of control values, in marked contrast to the well known positive inotropic effect of adrenaline on the heart twitch. This effect of adrenaline is directly dose dependent. Increasing [Ca]. diminishes the effect of adrena… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
16
0

Year Published

1969
1969
2010
2010

Publication Types

Select...
5
3

Relationship

0
8

Authors

Journals

citations
Cited by 34 publications
(18 citation statements)
references
References 42 publications
2
16
0
Order By: Relevance
“…3A). Furthermore, pronethalol (10 g. ml-') which blocks the effects of adrenaline in frog heart (Graham & Lamb, 1968, and Fig. 3A), has no effect on the potassium contracture.…”
Section: Resultsmentioning
confidence: 99%
“…3A). Furthermore, pronethalol (10 g. ml-') which blocks the effects of adrenaline in frog heart (Graham & Lamb, 1968, and Fig. 3A), has no effect on the potassium contracture.…”
Section: Resultsmentioning
confidence: 99%
“…The relaxant effect of adrenaline occurs at all membrane potentials and seems to be independent of [K]o or [Ca]o (Fig. 2 of Kavaler & Morad, 1966;Graham & Lamb, 1967).…”
Section: Discussionmentioning
confidence: 99%
“…see Fig. 2 of Graham & Lamb, 1967;Morad & Rolett, 1972). Since adrenaline does not alter significantly the magnitude of membrane depolarization produced by high concentrations of KCl (Graham & Lamb, 1967), adrenaline appears to have a direct relaxant effect on frog ventricular muscle.…”
Section: Figurementioning
confidence: 99%
See 1 more Smart Citation
“…The frog myocardium shows some of the features associated with the ISO response, including potentiation of phasic contraction (twitch) followed by an inhibition of tonic (maintained) tension [see Fan et al (Fan et al, 1996) and references therein], which is known as the 'paradoxical' cardiac action of adrenaline (Graham and Lamb, 1968). Moreover, as shown on isolated ventricular strips of the toad, ISO increases the rate of relaxation.…”
Section: Adrenergic Neuroendocrine Patternsmentioning
confidence: 99%