The Effect of Adrenocorticotrophic Hormone on Children With the Nephrotic Syndrome. Ii. Physiologic Observations on Discrete Kidney Functions and Plasma Volume 1

Treatment of Nephrosis With Pituitary Adrenocorticotrophin 1

“…There is a considerable increase in the clearance of "creatinine" in most of these patients, as has been previously observed (7). This improvement usually reaches a peak near the end of treatment, and subsequently declines.…”

A Study of the Mechanisms of Edema Formation in Patients with the Nephrotic Syndrome 1

“…The hypothesis that primary glomerular insufficiency is an important factor in the fluid retention of the nephrotic syndrome finds more direct support in the data of other investigators (35)(36)(37)(38): diuresis following treatment with corticotropin (25 or 50 Gm.) of the albumin infusion.…”

Measurement of Glomerular Filtration Rate in Children With Kidney Disease 12

“…In the latter observations, step-wise increases in serum inulin concentrations were achieved by increasing the concentration of inulin in the infusion fluid which was administered intravenously at a constant rate. The catheterization and infusion technique used for short-term simultaneous clearances has been described previously (6,9). Inulin was measured in serum and urine using resorcinol as described by Schreiner (10); PAH by the method of Smith and his associates (11); thiosulfate as described by Newman, Gilman and Philips (12); urea by the method of Archibald (13); and glucose as described by Nelson (14).…”

“…If specific methods (2,3) are used to determine endogenous creatinine in serum and urine, the creatinine: inulin clearance ratio is close to unity in normal infants, children (4) and adults (5). However, in patients with diminished kidney function, the creatinine 4 clearance is consistently higher than the clearance of inulin (4)(5)(6)(7). This fact suggests that in patients with kidney disease, there may be either tubular secretion of creatinine, tubular reabsorption of inulin, or both.…”