The Effect of Advanced Platelet-Rich Fibrin in Tissue Regeneration in Reconstructive and Graft Surgery: Systematic Review

Pereira, Vinícius Balan Santos; Barbirato, Davi da Silva; Lago, Carlos Augusto Pereira do; Vasconcelos, Belmiro Cavalcanti do Egito

doi:10.1097/scs.0000000000009328

Cited by 6 publications

(11 citation statements)

References 37 publications

(141 reference statements)

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“…al., the results showed a reduction in bone volume of 25% in the group with spontaneous healing and only 3% for the group in which the alveolar ridge was preserved [1]. Also, in other studies in which the same comparisons were made, the results were favorable for the preservation of the alveolar ridge [8,18,22,35,46,47,56,57]. The studies that analyzed the results of implant therapy had better outcomes for the preserved ridges than spontaneously healed alveoli [27,36,58].…”

Section: Discussionmentioning

confidence: 90%

Healing of Extraction Sites after Alveolar Ridge Preservation Using Advanced Platelet-Rich Fibrin: A Retrospective Study

Khaddour,

Ghiță,

Ionescu

et al. 2024

Bioengineering

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Background: Over time, numerous surgical procedures and biomaterials have been proposed for the reconstruction of post-extraction bone defects, each with their advantages and disadvantages. The main objective of this study was to evaluate dimensional changes in the alveolar bone 3 months after tooth extraction, before implant planning, comparing alveolar ridge preservation (ARP) with spontaneous healing. Methods: A total of 84 patients with non-restorable molars were included in the study. Forty-two patients received ARP with advanced platelet-rich fibrin (A-PRF) and spontaneous healing was evaluated in these patients. Cone beam computed tomography (CBCT) analysis performed before and after surgical intervention was used to determine the changes in vertical and horizontal bone dimensions produced after tooth extraction. Results: CBCT measurements showed reduction in both vertical and horizontal alveolar bone size in both groups. For the study group, the alveolar parameters (height, width) were higher compared to the control group. The percentage variations between dimensional differences from the two groups were 38.58% for height, and for width were 36.88% at 0 mm, 35.56% at 3 mm, 36.61% at 5 mm, and 38.73% at 7 mm. The differences were statistically significant (p ˂ 0.0005). Conclusions: The results obtained after ARP with A-PRF showed a reduced loss of bone volume compared to spontaneous healing.

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Section: Discussionmentioning

confidence: 90%

Healing of Extraction Sites after Alveolar Ridge Preservation Using Advanced Platelet-Rich Fibrin: A Retrospective Study

Khaddour,

Ghiță,

Ionescu

et al. 2024

Bioengineering

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“…Cell distribution is one of the advantages of the products of low-speed centrifugation, as this change leads to a more homogeneous distribution of cells in the buffy coat, improving the properties of the clot, which is not seen in products of high-speed centrifugation (e.g., L-PRF), in which a greater concentration of cells is found at the end of the clot near the transition with the area of red blood cells [ 21 , 22 , 23 ]. One study assessed this outcome [ 12 ], and as expected, A-PRF achieved significantly better results with regard to cell distribution in comparison to L-PRF.…”

Section: Discussionmentioning

confidence: 99%

Biological and Cellular Properties of Advanced Platelet-Rich Fibrin (A-PRF) Compared to Other Platelet Concentrates: Systematic Review and Meta-Analysis

Pereira,

Lago,

Almeida

et al. 2023

IJMS

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Platelet concentrates are used for cell induction and stimulation in tissue repair processes. The aim of the present systematic review and meta-analysis was to compare the biological and cellular properties of advanced platelet-rich fibrin (A-PRF) to those of other platelet concentrates. Searches were conducted on the PubMed/Medline, Scopus, Web of Science, Embase and LILACS databases using a search strategy oriented by the guiding question. A total of 589 records were retrieved. Seven articles of in vitro experimental studies were selected for qualitative data analysis and four were selected for meta-analysis. The release of growth factors, distribution of cells in the fibrin membrane, and cell viability, the fibrin network, and fibroblast migration were investigated. In the final analysis, statistically significant differences were found for the A-PRF group with regard to platelet-derived growth factor, transforming growth factor, epidermal growth factor and vascular endothelial growth factor at all assessment times. A difference was found with regard to bone morphogenetic protein only in the later assessment, and no differences among groups were found with regard to platelet-derived growth factor or insulin-like growth factor. The results of this systematic review and meta-analysis suggest that A-PRF has superior cellular properties and better release of growth factors compared to other platelet concentrates.

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“…Among the scrutinized materials, PRF emerged prominently for its capability to promote satisfactory new bone formation whilst preserving ridge contour [ 20 ]. In another review, Santos Pereira et al [ 21 ] dissected the advantages of advanced platelet-rich fibrin (A-PRF) in tissue regeneration amid reconstructive and jaw graft surgery. The insights from the study positioned A-PRF as a beneficial adjunct in sustaining ridge profile, bolstering bone density, and expediting tissue repair post-extraction [ 21 ].…”

Section: Main Textmentioning

confidence: 99%

“…In another review, Santos Pereira et al [ 21 ] dissected the advantages of advanced platelet-rich fibrin (A-PRF) in tissue regeneration amid reconstructive and jaw graft surgery. The insights from the study positioned A-PRF as a beneficial adjunct in sustaining ridge profile, bolstering bone density, and expediting tissue repair post-extraction [ 21 ]. Additionally, the review illuminated the potential of A-PRF in alleviating post-operative pain and swelling, alongside contributing to swifter epithelial healing [ 21 ].…”

Section: Main Textmentioning

confidence: 99%

“…The insights from the study positioned A-PRF as a beneficial adjunct in sustaining ridge profile, bolstering bone density, and expediting tissue repair post-extraction [ 21 ]. Additionally, the review illuminated the potential of A-PRF in alleviating post-operative pain and swelling, alongside contributing to swifter epithelial healing [ 21 ].…”

Section: Main Textmentioning

confidence: 99%

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Advancements in alveolar bone grafting and ridge preservation: a narrative review on materials, techniques, and clinical outcomes

Kim,

Kim

2024

Maxillofac Plast Reconstr Surg

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This narrative review systematically explores the progression of materials and techniques in alveolar ridge preservation (ARP). We commence by delineating the evolution from traditional ARP methods to cutting-edge alternatives, including platelet-rich fibrin, injectable bone repair materials, and hydrogel systems. Critical examination of various studies reveals these innovative approaches not only accelerate bone healing but also significantly improve patient-reported outcomes, such as satisfaction, pain perception, and overall quality of life. Emphasis is placed on the correlation between advanced ARP techniques and enhanced patient comfort and clinical efficacy, underscoring their transformative potential in dental implantology. Highlighting the effectiveness of ARP, the implant survival rate over a span of 5 to 7 years was high, showcasing the reliability and success of these methods. Further, patients expressed high aesthetic satisfaction with the soft tissue outcome, evidenced by an average visual analog scale (VAS) score of 94. This positive aesthetic appraisal is linked to the clinical health of implants, potentially due to the employment of tooth-supported surgical guides. The economic analysis reveals a varied cost range for bone graft substitutes ($46.2 to $140) and socket sealing materials ($12 to $189), with a noteworthy correlation between the investment in barrier membranes and the diminished horizontal and vertical ridge resorption. This suggests that membrane usage significantly contributes to preserving ridge dimensions, offering a cost-effective strategy for enhancing ARP outcomes. In conclusion, this review illuminates the significant advancements in ARP, highlighting the shift towards innovative materials and techniques that not only promise enhanced bone regeneration and reduced healing times but also improve patient satisfaction and aesthetic outcomes. The documented high implant survival rate and the beneficial economic implications of membrane use further validate the effectiveness of contemporary ARP strategies, paving the way for their broader adoption in dental implantology.

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The Effect of Advanced Platelet-Rich Fibrin in Tissue Regeneration in Reconstructive and Graft Surgery: Systematic Review

Cited by 6 publications

References 37 publications

Healing of Extraction Sites after Alveolar Ridge Preservation Using Advanced Platelet-Rich Fibrin: A Retrospective Study

Healing of Extraction Sites after Alveolar Ridge Preservation Using Advanced Platelet-Rich Fibrin: A Retrospective Study

Biological and Cellular Properties of Advanced Platelet-Rich Fibrin (A-PRF) Compared to Other Platelet Concentrates: Systematic Review and Meta-Analysis

Advancements in alveolar bone grafting and ridge preservation: a narrative review on materials, techniques, and clinical outcomes

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