The effect of adverse and positive experiences on inflammatory markers in Australian and UK children

Priest, Naomi; Guo, Shuaijun; Gondek, Dawid; Lacey, Rebecca; Burgner, David; Downes, Marnie; Slopen, Natalie; Goldfeld, Sharon; Moreno‐Betancur, Margarita; Kerr, Jessica A; Cahill, Stephanie; Wake, Melissa; Juonala, Markus; Lycett, Kate; O’Connor, Meredith

doi:10.1016/j.bbih.2022.100550

Cited by 1 publication

(1 citation statement)

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“…Despite the potential drawbacks of binarization (e.g., loss of information, reduced power, increased risk for type II error), our decision was determined by the constraints of our methodological approach and a greater interpretability of the findings. Since the histogram of latent scores did not give a clear cutoff (eFigure 1), a cutoff at its 75th percentile was chosen as a common practice for dichotomising risk factors in the literature [ 48 , 49 ].…”

Section: Methodsmentioning

confidence: 99%

Mediating mechanisms of the relationship between exposure to deprivation and threat during childhood and adolescent psychopathology: evidence from the Millennium Cohort Study

Ning,

Gondek,

Pereira

et al. 2023

Eur Child Adolesc Psychiatry

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The key aim of our study was to examine pathways from exposure to childhood adversities (i.e., deprivation and threat) to adolescent psychopathology. The assessed mediating mechanisms included cognitive ability and emotion regulation, as proposed by the Dimensional Model of Adversity and Psychopathology (DMAP). The study comprised participants from the nationally representative Millennium Cohort Study. Latent scores for deprivation and threat were derived using confirmatory factor analysis from indicators collected when participants were at age of 9 months, 3 and 5 years. Cognitive ability was measured using the Verbal Similarities subscale of the British Ability Scales II at age 11, and emotion regulation was measured using emotion dysregulation subscale of the Child Social Behavioural Questionnaire at age 7. Psychopathology, defined as psychological distress, was assessed using the Kessler 6 scale at age 17. We conducted causal mediation analysis adjusting for multiple confounding factors. We did not find total effect of either exposure to deprivation or threat on psychological distress, but we did find significant indirect effects of exposure to deprivation on psychological distress via cognitive ability (− 0.11, 95% CI − 0.20 to − 0.05) and emotion regulation (0.03, 0.02 to 0.12), and exposure to threat on psychological distress via cognitive ability (− 0.04, − 0.07 to − 0.01) and emotion regulation (0.09, 0.03 to 0.15). The lack of associations between deprivation or threat and psychological distress may be due to reporting bias or developmental period of psychopathology. Results of mediation analysis partially support the DMAP but indicate limited benefits to reduce adolescent psychological distress by targeting cognitive ability or emotion regulation to those exposed to childhood adversities.

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Section: Methodsmentioning

confidence: 99%