The effect of aerobic physical training on cardiac autonomic control of rats submitted to ovariectomy

Tezini, Geisa C.S.V.; Silveira, Larissa C.R.; Villa-clé, Paula G.; Jacinto, Cynthia P.; Sacco, Thaísa Helena Roseli Di; Souza, Hugo Celso Dutra de

doi:10.1097/gme.0b013e318182d352

Cited by 24 publications

(13 citation statements)

References 52 publications

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“…Despite of some reports using normotensive rats have reported increases of arterial pressure post-ovariectomy (Mercier et al 2002;Thorin et al 2003;Irigoyen et al 2005;Souza et al 2007), our data match with almost all studies using normotensive rats, which did not show an increase in arterial pressure post-ovariectomy (Takezawa et al 1994a,b;Lam et al 2002;Brandin et al 2003;Abdel-Rahman 1998, 2004;Tezini et al 2008). In some of these papers, arterial pressure was also evaluated for long term by means of telemetry system, in which manipulation stress effects are absent (Takezawa et al 1994a,b;Brandin et al 2003;El-Mas and Abdel-Rahman 2004).…”

Section: Discussionsupporting

confidence: 83%

Heart rate and arterial pressure variability and baroreflex sensitivity in ovariectomized spontaneously hypertensive rats

et al. 2009

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Section: Discussionsupporting

confidence: 83%

Heart rate and arterial pressure variability and baroreflex sensitivity in ovariectomized spontaneously hypertensive rats

et al. 2009

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“…When genders were compared, regardless of the level of physical conditioning, men presented an autonomic balance in favor of sympathetic modulation characterized by greater LF oscillations, whereas women presented an autonomic balance in favor of HF oscillations. These discrepant results were more evident in well-conditioned subjects (i.e., the moderate and high aerobic capacity groups), showing that gender can indeed influence cardiac autonomic modulation [31,46-48]. In accordance with these observations, the literature has shown that middle-aged women have the greatest variations in the spectral indices of HRV and lowest values of AP at rest conditions compared to men of the same age group.…”

Section: Discussionmentioning

confidence: 64%

“…In accordance with these observations, the literature has shown that middle-aged women have the greatest variations in the spectral indices of HRV and lowest values of AP at rest conditions compared to men of the same age group. This finding indicates that the female population would present an increased vagal cardiac modulation, which would be evidenced by higher HF values and lower LF values [30,46-48]. However, it was also shown that such a discrepancy in the spectral parameters of HRV decreases between men and women when their age is above 50 years old [46].…”

Section: Discussionmentioning

confidence: 99%

Cardiac Autonomic Modulation Is Determined by Gender and Is Independent of Aerobic Physical Capacity in Healthy Subjects

et al. 2013

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BackgroundAerobic physical capacity plays an important role in reducing morbidity and mortality rates in subjects with cardiovascular diseases. This action is often related to an improvement in the autonomic modulation of heart rate variability (HRV). However, controversies remain regarding the effects of physical training on cardiac autonomic control in healthy subjects. Therefore, our objective was to investigate whether aerobic capacity interferes with the autonomic modulation of HRV and whether gender differences exist.MethodsHealthy men and women (N=96) were divided into groups according to aerobic capacity: low (VO2: 22-38 ml/kg-1 min-1), moderate (VO2: 38-48 ml/kg-1 min-1) and high (VO2 >48 ml/kg-1 min-1.) We evaluated the hemodynamic parameters and body composition. The autonomic modulation of HRV was investigated using spectral analysis. This procedure decomposes the heart rate oscillatory signal into frequency bands: low frequency (LF=0.04-0.15Hz) is mainly related to sympathetic modulation, and high frequency (HF=0.15-0.5Hz) corresponds to vagal modulation.ResultsAerobic capacity, regardless of gender, determined lower values of body fat percentage, blood pressure and heart rate. In turn, the spectral analysis of HRV showed that this parameter did not differ when aerobic capacity was considered. However, when the genders were compared, women had lower LF values and higher HF values than the respective groups of men.ConclusionThe results suggest that aerobic physical capacity does not interfere with HRV modulation; however, the cardiac modulatory balance differs between genders and is characterized by a greater influence of the autonomic vagal component in women and by the sympathetic component in men.

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“…Exercise training may improve the cardiac autonomic balance by increasing vagal regulation while decreasing sympathetic regulation in rats (Souza et al 2007;Tezini et al 2009;Rossi et al 2009). It is an eVective means of reducing the levels of C-reactive protein, IL-1, IL-6 and interferongamma levels and increasing IL-10 levels in coronary artery disease patients, which collectively improve the coronary risk proWles (Goldhammer et al 2005).…”

Section: Hyperlipidemia Avects the Expression Of Cholinesterase-positmentioning

confidence: 97%

“…It is well accepted that exercise restores proWles of inXammatory cytokines and enhances the eVects of antiatherosclerotic agents (Adamopoulos et al 2002;Goldhammer et al 2005;Teixeira de Lemos et al 2009). Moreover, exercise has also been veriWed to increase HRV and BRS, lower blood pressure and reduce cardiovascular autonomic dysfunction in rats (Bertagnolli et al 2006;Souza et al 2007;Tezini et al 2009). However, there are no substantial studies to assess whether exercise may restore the function of cardiac vagus nerve in the hyperlipidemic heart, thereby improving cardiac function.…”

Section: Introductionmentioning

confidence: 98%

Exercise benefits cardiovascular health in hyperlipidemia rats correlating with changes of the cardiac vagus nerve

et al. 2009

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The role of exercise training on hemodynamic parameters, blood lipid profiles, inflammatory cytokines, cholinesterase-positive nerves and muscarinic cholinergic (M(2)) receptors expression in the heart was investigated in Sprague-Dawley male rats with hyperlipidemia (HL). The rats were subjected to a high-fat diet and exercise training for 8 weeks, and then the hemodynamic parameters, the profiles of blood lipid and inflammatory cytokines, and the expression of cholinesterase-positive nerves and M(2) receptors were measured. HL rats displayed cardiac dysfunction, dysregulation of inflammatory cytokines, and decreased cholinesterase-positive nerves and M(2) receptors expression. The combination of hyperlipidemia with exercise training (AT) restored the profiles of blood lipids and the levels of inflammatory cytokines. In addition, AT and HL + AT improved cardiac function with increasing cholinesterase-positive nerves and M(2) receptors expression. Overall, these data show that the increased expression of cholinesterase-positive nerves and M(2) receptors in the heart is partially responsible for the benefits of exercise training on cardiac function in hyperlipidemia rats.

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The effect of aerobic physical training on cardiac autonomic control of rats submitted to ovariectomy

Cited by 24 publications

References 52 publications

Heart rate and arterial pressure variability and baroreflex sensitivity in ovariectomized spontaneously hypertensive rats

Heart rate and arterial pressure variability and baroreflex sensitivity in ovariectomized spontaneously hypertensive rats

Cardiac Autonomic Modulation Is Determined by Gender and Is Independent of Aerobic Physical Capacity in Healthy Subjects

Exercise benefits cardiovascular health in hyperlipidemia rats correlating with changes of the cardiac vagus nerve

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