The effect of age and gender on arterial stiffness in healthy Caucasian Canadians

Noon, Joseph P.; Trischuk, Timothy C; Gaucher, Sylvia A; Galante, Sean; Scott, Roger L.

doi:10.1111/j.1365-2702.2007.02155.x

Cited by 33 publications

(26 citation statements)

References 20 publications

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“…The studies with the higher mean AIx at baseline (the current study and Noda et al) have similar standard deviations to Phillips et al and Kohler et al, suggesting that the AIx may be a more useful measure in patients with severe cardiovascular disease because the variability becomes proportionally less. Similarly, high levels of variability have been found in a healthy sample [33] and a sample comprising the offspring of patients with familial hypertension [32], but other studies reporting the AIx in a healthy population (23±1%) [34] and in young African-American and white men (0.5±2.4% and −9.0 ± 1.3%, respectively) [35] both reported far smaller standard deviations. All of these studies used the SphygmoCor equipment and software.…”

Section: Discussionmentioning

confidence: 92%

Pulse wave analysis in a pilot randomised controlled trial of auto-adjusting and continuous positive airway pressure for obstructive sleep apnoea

2010

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Section: Discussionmentioning

confidence: 92%

Pulse wave analysis in a pilot randomised controlled trial of auto-adjusting and continuous positive airway pressure for obstructive sleep apnoea

2010

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“…A possible explanation is that in ED patients without VRFs, the occurrence of impaired arterial stiffness, at a lower grade than patients with VRFs, may be accounted for by the presence of low-grade inflammation, which has not been investigated in this study but is known to alter synthesis of structural proteins of the arterial wall, such as collagen, and therefore results in increased arterial stiffness (Hingorani et al, 2000). We are aware that increased arterial stiffness is correlated with ageing (Noon et al, 2008). However, in our population AI was higher in ED patients with and without risk factors compared with the controls with risk factors; this latter group was age-matched with that of ED patients.…”

Section: Endothelial Dysfunction and Erectile Dysfunctionmentioning

confidence: 90%

The application of digital pulse amplitude tonometry to the diagnostic investigation of endothelial dysfunction in men with erectile dysfunction

et al. 2010

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The application of digital pulse amplitude by fingertip peripheral arterial tonometry (PAT) device in patients with erectile dysfunction (ED) has never been performed. We investigated the diagnostic value of reactive hyperaemia (RH) and augmentation index (AI) as evaluated using PAT in men with ED of any origin. A total of 40 patients underwent diagnostic investigation for ED, including dynamic penile duplex ultrasound (PDU) and PAT device. Moreover, 30 patients without ED served as controls. According to PDU cutoff at 35 cm/sec, patients were divided into vascular (n = 30) and nonvascular (n = 10) ED aetiology. Moreover, controls with (n = 10) or without (n = 20) vascular risk factors (VRFs) were studied in a separate analysis. Average RH-PAT was not different in men with or without ED (P = 0.56) independently of VRFs. The AI was higher in men with ED compared with the controls (P < 0.0001) as well as when controlled for the presence or absence of VRFs (P < 0.0001). An inverse relationship between AI and PSV was also found (r² = -0.72, P < 0.0001). In conclusion, an increased AI but not an impaired RH-PAT is present in men with vascular ED independently of VRFs and may represent an early detection of vascular impairment that may precede endothelial dysfunction in populations at low risk for developing vascular ED.

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“…As Dockery and Stone (2007) suggest, the evidence may also point to increased susceptibility to air pollution due to an underlying cardiac profile that is more common among women, given that sex differences in the studies described appear more consistent with respect to cardiovascular outcomes. Some studies have shown sex differences in the cardiovascular pathways that air pollution may impact (Hoffmann et al 2009; Kublickiene and Luksha 2008; Noon et al 2008; Sztajzel et al 2008). However, the specific biological mechanisms through which PM air pollution affects all-cause mortality and cerebrovascular and CVD outcomes have not been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

Particulate Matter Exposures, Mortality, and Cardiovascular Disease in the Health Professionals Follow-up Study

Puett

Hart

Suh

et al. 2011

Environ Health Perspect

126

100

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Background: The association of all-cause mortality and cardiovascular outcomes with air pollution exposures has been well established in the literature. The number of studies examining chronic exposures in cohorts is growing, with more recent studies conducted among women finding risk estimates of greater magnitude. Questions remain regarding sex differences in the relationship of chronic particulate matter (PM) exposures with mortality and cardiovascular outcomes.Objectives: In this study we explored these associations in the all-male Health Professionals Follow-Up Study prospective cohort.Methods: The same spatiotemporal exposure estimation models, similar outcomes, and biennially updated covariates were used as those previously applied in the female Nurses’ Health Study cohort.Results: Among 17,545 men residing in the northeastern and midwestern United States, there were 2,813 deaths, including 746 cases of fatal coronary heart disease (CHD). An interquartile range change (4 µg/m3) in average exposure to PM ≤ 2.5 µm in diameter in the 12 previous months was not associated with all-cause mortality [hazard ratio (HR) = 0.94; 95% confidence interval (CI), 0.87–1.00] or fatal CHD (HR = 0.99; 95% CI, 0.87–1.13) in fully adjusted models. Findings were similar for separate models of exposure to PM ≤ 10 µm in diameter and PM between 2.5 and 10 µm in diameter and for copollutant models.Conclusions: Among this cohort of men with high socioeconomic status living in the midwestern and northeastern United States, the results did not support an association of chronic PM exposures with all-cause mortality and cardiovascular outcomes in models with time-varying covariates. Whether these findings suggest sex differences in susceptibility or the protective impact of healthier lifestyles and higher socioeconomic status requires additional investigation.

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The effect of age and gender on arterial stiffness in healthy Caucasian Canadians

Abstract: Applanation tonometry, used extensively by nurses, provides early detection of central haemodynamic changes and vascular compliance at all ages. Knowledge of arterial stiffness could guide the management of primary prevention in the nursing cardiovascular risk reduction clinic.

Cited by 33 publications

References 20 publications

Pulse wave analysis in a pilot randomised controlled trial of auto-adjusting and continuous positive airway pressure for obstructive sleep apnoea

Pulse wave analysis in a pilot randomised controlled trial of auto-adjusting and continuous positive airway pressure for obstructive sleep apnoea

The application of digital pulse amplitude tonometry to the diagnostic investigation of endothelial dysfunction in men with erectile dysfunction

Particulate Matter Exposures, Mortality, and Cardiovascular Disease in the Health Professionals Follow-up Study

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