The Effect of Age at Exposure on Radiation-Induced Polydipsia in the Rat

Osborn, G. K.; Jones, Dave C.; Kimeldorf, Donald J.

doi:10.2307/3571684

Cited by 2 publications

(1 citation statement)

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“…Polydipsia due to altered plasma volume occurs in many animal species. It can occur within a few hours of exposure and maintain for a few days [49, 50]. It is rarely clinically evident and most patients correct the effect (asymptomatically) by oral fluid and electrolyte replacement.…”

Section: Metabolic Markers Of Normal Tissue Response To Radiation mentioning

confidence: 99%

Molecular markers of radiation-related normal tissue toxicity

Okunieff

Chen

Maguire

et al. 2008

Cancer Metastasis Rev

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Over the past five decades, those interested in markers of radiation effect have focused primarily on tumor response. More recently, however, the view has broadened to include irradiated normal tissues -markers that predict unusual risk of side-effects, prognosticate during the prodromal and therapeutic phases, diagnose a particular toxicity as radiation-related, and, in the case of bioterror, allow for tissue-specific biodosimetry. Currently, there are few clinically useful radiation-related biomarkers. Notably, levels of some hormones such as thyroid-stimulating hormone (TSH) have been used successfully as markers of dysfunction, indicative of the need for replacement therapy, and for prevention of cancers. The most promising macromolecular markers are cytokines: TGFβ, IL-1, IL-6, and TNFα being lead molecules in this class as both markers and targets for therapy. Genomics and proteomics are still in nascent stages and are actively being studied and developed.

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Section: Metabolic Markers Of Normal Tissue Response To Radiation mentioning

confidence: 99%