The effect of age on Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn contents in intact human prostate investigated by neutron activation analysis

Zaichick, Sofia; Zaichick, Vladimir

doi:10.1016/j.apradiso.2011.02.010

Cited by 60 publications

(75 citation statements)

References 49 publications

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“…The results for all trace element mass fractions in the prostates of the control group are in accordance with our earlier findings in prostates of apparently healthy men aged over 41 years (S. Zaichick & V. Zaichick, 2010, 2011a, 2011bS. Zaichick et al, 2012a;V.…”

Section: Resultssupporting

confidence: 81%

“…(Zaichick & Zaichick, 2011b;Zaichick & Zaichick, 2012a) suggests an acceptable accuracy of the measurements performed on the prostate tissue samples.…”

Section: Resultsmentioning

confidence: 99%

“…Zaichick, 2004). A significant tendency of age-related increase in Zn, and many other trace element mass fractions in the normal prostate was recently demonstrated by us (S. Zaichick & V. Zaichick, 2010, 2011a, 2011bS. Zaichick et al, 2012a;V.…”

Section: Introductionmentioning

confidence: 99%

“…Details of the analytical methods and procedures used here such as nuclear reactions, radionuclides, gamma-energies, isotopes, spectrometers, spectrometer parameters and operating conditions were presented in our earlier publications (S. Zaichick & V. Zaichick, 2011b;S. Zaichick et al, 2012a).…”

Section: Analytical Proceduresmentioning

confidence: 99%

“…Simultaneously, the same procedure was performed in autoclaves without tissue samples (only HNO 3 +H 2 O 2 + deionized water), and the resultant solutions were used as control samples. (Zaichick & Zaichick, 2011b;Zaichick & Zaichick, 2012a).…”

Section: Sample Preparationmentioning

confidence: 99%

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Prostatic Tissue Levels of 43 Trace Elements in Patients with Prostate Adenocarcinoma

Zaichick

2016

CCO

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Adenocarcinoma of prostate gland is an internationally important health problem in men, particularly in developed countries. The aim of this exploratory study was to evaluate whether significant changes in the prostatic tissue levels of trace elements exist in the malignantly transformed prostate. Prostatic tissue levels of 43 trace elements were prospectively evaluated in 36 patients with prostate adenocarcinoma and 37 healthy males. Measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma mass spectrometry, respectively. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for trace element analysis. The reliability of difference in the results between normal and cancerous prostate tissues was evaluated by Student's t-test. It was found that the contents of Ag, Al, Au, B, Be, Br, Ce, Cr, Dy, Er, Fe, Gd, Hg, Li, Mn, Nd, Ni, Pr, Sb, Sn, Th, Tl, Y, and Zr were significantly higher while those of Cd, Co, Rb, Sc, Se, and Zn were significantly lower in cancerous tissues than in normal tissues. Moreover, it was shown that malignant transformation significantly changed the relationships of trace elements in prostate. Thus, in adenocarcinoma transformed prostate tissue the trace element metabolism is significantly disturbed.

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Section: Resultssupporting

confidence: 81%

“…(Zaichick & Zaichick, 2011b;Zaichick & Zaichick, 2012a) suggests an acceptable accuracy of the measurements performed on the prostate tissue samples.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Analytical Proceduresmentioning

confidence: 99%

Section: Sample Preparationmentioning

confidence: 99%

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Prostatic Tissue Levels of 43 Trace Elements in Patients with Prostate Adenocarcinoma

Zaichick

2016

CCO

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Reference man for radiological protection: 71 chemical elements’ content of the prostate gland (normal and cancerous)

Zaichick

Wynchank

2021

Radiat Environ Biophys

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Relations of the Al, B, Ba, Br, Ca, Cl, Cu, Fe, K, Li, Mg, Mn, Na, P, S, Si, Sr, and Zn mass fractions to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands

Zaichick

2014

Biometals

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The variation with age of the 18 trace element mass fractions and some histological characteristics of intact prostate glands of 50 subjects aged 0-30 years was investigated by instrumental neutron activation analysis, inductively coupled plasma atomic emission spectrometry, and a quantitative morphometric analysis. Mean values ± standard error of the mean (M ± SΕΜ) for the mass fractions (in milligrams per kilogram wet tissue) of these trace elements in pre-puberty were: Al 28.5 ± 9.0, B 0.40 ± 0.11, Ba 1.48 ± 0.44, Br 10.5 ± 1.5, Ca 241 ± 30, Cl 3,203 ± 278, Cu 3.51 ± 0.89, Fe 33.7 ± 4.1, K 2,364 ± 145, Li 0.020 ± 0.004, Mg 153 ± 23, Mn 0.46 ± 0.06, Na 2,286 ± 130, P 1,391 ± 100, S 1,698 ± 132, Si 62 ± 11, Sr 0.38 ± 0.08, and Zn 27.6 ± 2.3. During puberty and postpuberty, when there is a significant increase in circulating androgens, the mean values were: Al 7.2 ± 1.4, B 0.21 ± 0.05, Ba 0.25 ± 0.06, Br 5.8 ± 1.0, Ca 433 ± 81, Cl 2,314 ± 201, Cu 1.77 ± 0.13, Fe 20.9 ± 1.6, K 2,585 ± 118, Li 0.0088 ± 0.0014, Mg 232 ± 27, Mn 0.34 ± 0.04, Na 1,875 ± 107, P 1,403 ± 98, S 1,673 ± 73, Si 22.2 ± 3.1, Sr 0.22 ± 0.03, and Zn 93.3 ± 8.9. Mean values (M ± SΕΜ) of percent volumes (%) of the stroma, epithelium and lumen in the prostate before puberty were 73.4 ± 2.6, 20.4 ± 1.7, and 4.45 ± 0.94, respectively, versus 46.5 ± 2.5, 38.5 ± 1.9, and 14.9 ± 1.2 during puberty and postpuberty. This work's results confirm that the Zn mass fraction in prostate tissue is an androgen-dependent parameter. For the first time it has been demonstrated that the glandular lumen is a main pool of Ca, Mg, and Zn accumulation and that the stroma is a main pool of Al, B, Ba, Br, Cl, Cu, Fe, Mn, Na, and Si accumulation in the normal human prostate, for the age range 0-30 years. It was concluded that the Ca, Mg, and Zn binds tightly within the prostatic fluid, because the volume of glandular lumen reflects the volume of prostatic fluid.

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The effect of age on Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn contents in intact human prostate investigated by neutron activation analysis

Cited by 60 publications

References 49 publications

Prostatic Tissue Levels of 43 Trace Elements in Patients with Prostate Adenocarcinoma

Prostatic Tissue Levels of 43 Trace Elements in Patients with Prostate Adenocarcinoma

Reference man for radiological protection: 71 chemical elements’ content of the prostate gland (normal and cancerous)

Relations of the Al, B, Ba, Br, Ca, Cl, Cu, Fe, K, Li, Mg, Mn, Na, P, S, Si, Sr, and Zn mass fractions to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands

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