The effect of age on phenotype of primary rhegmatogenous retinal detachment

Ferrara, Mariantonia; Al-Zubaidy, Mohaimen; Song, Anna; Avery, Peter; Williamson, Tom H.; Steel, David; Babar, Atiq R.; Balaggan, Kamaljit S.; Casswell, A G; Chandra, Aman; Charles, Stephen; Cochrane, Timothy; Crama, Niels; Simplicio, Sandro Di; Ellabban, Abdallah A.; Ellis, John; Etten, Peter van; Figueroa, Marta S.; Goldsmith, Craig; Hillier, Roxane J.; Hughes, Edward; Ivanova, Tsveta; Jalil, Assad; Jenkins, Huw; Khan, Ashraf; Laidlaw, D A H; Mer, Yannick Le; Meireles, Angelina; Morris, Andrew H.; Newsom, Richard; Papastavrou, Vasileios T.; Park, Jonathan C.; Ramkissoon, Yashin; Sanchez-Chicharro, Diego; Sheard, Richard; Smith, Jonathan; Cornish, Kurt Spiteri; Steel, David; Tanner, Vaughan; Vayalambrone, Deepak; Williamson, Thomas H.; Winder, Stephen; Yorston, David

doi:10.1038/s41433-022-02061-y

Cited by 11 publications

(11 citation statements)

References 30 publications

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“…Mean age of all patients with RD in our cohort was 61 years; in the bilateral group, it was 55 years of age when the initial eye had an RD and 57 years for the subsequent eye. Recently, the BEAVRS and EURETINA VR RD Outcomes Group found that the risk for fellow eye RD decreased linearly with age [11]. Data from the present study, however, show a decreasing proportion of fellow eye RD only in the age groups over 50 years.…”

Section: Age Sex Lens Statuscontrasting

confidence: 83%

Characteristics of Bilateral Retinal Detachment

et al. 2022

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Introduction: Rhegmatogenous retinal detachment (RD) is still a sight threatening and potentially blinding disease, especially if both eyes are affected. The purpose of this study is analysing the specific characteristics of bilateral rhegmatogenous retinal detachment (RD). Methods: The files of all 5791 consecutive eyes undergoing vitreoretinal surgery for uncomplicated RD in a single tertiary retinal centre between Jan 2005 und June 2021 were retrospectively reviewed. Results: 300 patients (600 eyes) had bilateral retinal detachment. Interval between initial and subsequent RD surgery was 2.6 ± 2.8 (mean ± SD, median 1.5) years. Symptoms were reported by the patients for 20 ± 75 (median 5) days before presentation in the initial eye and 12 ± 32 (median 4) days in the subsequent eye. 220 patients were male (73%), mean age at initial RD was 55 years. 183 (61%) of the initial RD eyes were phakic. In the initial eye more patients had a detached macula, worse visual acuity and more quadrants involved. Primary anatomic success rate was higher in the subsequent eye (90%) compared to the initial eye (83%). There was no difference in the reattachment rate of fellow eyes with primary failure in the first eye (91%) compared to those with primary success in the first eye (90%). There was a high symmetry between the eyes in terms of type of retinal break, number of breaks and presumed localization of the causative retinal break. Conclusion: Patients with bilateral RD were more common male and younger than the group of all RD patients. The proportion of pseudophakia was not different. The majority of fellow eye RD occurred within two years after the RD in the first eye. Second eye RD was less advanced and had a better anatomical repair rate. Despite their experience in the first eye and despite typical symptoms patients presented only after in mean 12 days with RD in the second eye. RD in the initial and the subsequent eye showed a high symmetry. The anatomic result in the first eye is not a predictor for the anatomic results in the subsequent eye.

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Section: Age Sex Lens Statuscontrasting

confidence: 83%

Characteristics of Bilateral Retinal Detachment

et al. 2022

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“…The greatest excess of male RRD overall was in the 50-70-year age range, accounting for approximately 65% of cases, whereas after 80 years no clear sex predominance can be detected, consistently with two recent large retrospective studies [21,22]. It has previously been suggested the male predominance relates to trauma, but we excluded RRD directly attributable to recent trauma.…”

Section: Discussionsupporting

confidence: 67%

The effect of sex and laterality on the phenotype of primary rhegmatogenous retinal detachment

Ferrara

Song²,

Al-Zubaidy³

et al. 2023

Eye

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Background To assess the effect of sex and laterality on clinical features of primary rhegmatogenous retinal detachment (RRD). Method This study is a retrospective analysis of data prospectively collected. We extracted data from two online datasets over a 7-year period of patients older than 16 years who had undergone surgery for primary RRD. Data on baseline characteristics were analyzed to compare males versus females, and right versus left eyes. Results Of 8133 eyes analyzed, 4342 (53.4%) were right. The overall male predominance (63.7%) was more marked in the age range 50–69 years. Men were more commonly pseudophakic and presented more frequently with baseline posterior vitreous detachment (PVD). Female sex was significantly associated with baseline myopia, retinal holes as causative retinal break, and isolated inferior RD. Men had more frequent foveal involvement, greater RRD extent, greater numbers and larger sized retinal tears including dialysis and giant retinal tears. Regarding laterality, foveal involvement, larger retinal breaks, isolated temporal RD and temporal retinal breaks were more common in right eyes, whereas left eyes were more myopic at baseline and presented more frequently with isolated nasal RD and nasal retinal breaks. Conclusions This study confirmed the predominance of male sex and right laterality in RRD. Sex and laterality were associated with multiple presenting features of RRD including extent, break distribution, number, size and type, as well as RD distribution.

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“…A recent study of 8133 eyes found up to 20% of primary RRDs occurred in those younger than 50 years, with the large majority (83%) being phakic. 18 The study also found that the younger cohort was significantly associated with myopia and exhibited a myopia-related RRD phenotype. By performing secondary SB after failed PR, these patients may not require PPV, thus avoiding the potential loss of accommodation and anisometropia associated with the ensuing cataract surgery that is commonly required after PPV.…”

Section: Discussionmentioning

confidence: 77%

“… 12 , 13 , 15 – 17 In particular, there is a lack of data comparing the success rates between SB and PPV as secondary procedures after failed PR. This is an important consideration given that a substantial proportion of patients with RRD may be young, myopic, and with a clear crystalline lens who are likely to require cataract surgery after PPV, 18 thus losing their ability to accommodate and potentially developing symptomatic anisometropia.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Scleral Buckling After Failed Pneumatic Retinopexy

Tran,

Chen,

et al. 2023

Journal of VitreoRetinal Diseases

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Purpose: To assess the visual and anatomic outcomes of eyes that had secondary scleral buckle (SB) surgery after unsuccessful pneumatic retinopexy (PR) for rhegmatogenous retinal detachment (RRD). Methods: A retrospective study, performed over a 12-year period, comprised patients who had secondary SB procedures after failed primary PR. Clinical parameters (eg, best-corrected visual acuity [BCVA], lens status, macula status, details of RRD and subretinal fluid) were assessed at presentation, before additional procedures, and at follow-up (6 months, 1 year, and last visit). Statistical comparisons were made using Brown-Forsythe and Welch analysis of variance tests, with significance levels set at P < .05. Results: Fifty-four eyes with adequate follow-up were included. Forty-four (81.5%) of 54 eyes had successful retinal reattachment with secondary SB alone. The remaining eyes had subsequent pars plana vitrectomy (PPV). Patients presenting with macula-on RRD who had successful secondary SB had no statistically significant change in BCVA from baseline (mean final logMAR 0.23 ± 0.25 [Snellen 20/34]; P = .999). There was a statistically significant improvement in BCVA in patients presenting with macula-off RRD who had successful secondary SB (mean final logMAR 0.32 ± 0.36 [20/42]; P < .001 and mean change in logMAR −1.06 ± 0.85). Ten patients presenting with macula-off RRD who had failed secondary SB had a significant improvement in the final BCVA (mean final logMAR 0.22 ± 0.28 [20/33]; P = .044), despite the need for an additional PPV to achieve reattachment. Conclusions: Secondary SB remains a good option for RRD repair after unsuccessful PR and may avoid the need for PPV.

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The effect of age on phenotype of primary rhegmatogenous retinal detachment

Cited by 11 publications

References 30 publications

Characteristics of Bilateral Retinal Detachment

Characteristics of Bilateral Retinal Detachment

The effect of sex and laterality on the phenotype of primary rhegmatogenous retinal detachment

Outcomes of Scleral Buckling After Failed Pneumatic Retinopexy

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